Research graph
References from Identification of cuproptosis-realated key genes and pathways in Parkinson’s disease via bioinformatics analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Challenges in the diagnosis of Parkinson’s disease
10.1016/s1474-4422(21)00030-2 · 2021 · External reference
Progress towards therapies for disease modification in Parkinson’s disease
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10.1186/s40035-020-00223-0 · 2020 · External reference
Metals in Alzheimer’s and Parkinson’s diseases.
10.1016/j.cbpa.2008.02.019 · 2008 · External reference
Mitochondrial dysfunction and oxidative stress in Parkinson’s disease
2013 · External reference
Mitochondrial quality control in health and in Parkinson’s disease
10.1152/physrev.00041.2021 · 2022 · External reference
Inflammation in Parkinson’s disease: role of glucocorticoids
2015 · External reference
The genetic architecture of Parkinson’s disease
10.1016/s1474-4422(19)30287-x · 2020 · External reference
Copper signaling in the mammalian nervous system: synaptic effects
10.1002/jnr.23143 · 2013 · External reference
Copper Dyshomeostasis in Neurodegenerative Diseases-Therapeutic Implications.
10.3390/ijms21239259 · 2020 · External reference
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders
10.1021/acs.molpharmaceut.7b00841 · 2018 · External reference
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson’s Disease
10.1089/ars.2015.6343 · 2016 · External reference
Copper induces cell death by targeting lipoylated TCA cycle proteins
10.1126/science.abf0529 · 2022 · External reference
Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy
10.1016/j.tibs.2020.11.007 · 2021 · External reference
Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism
10.1016/j.stemcr.2021.04.022 · 2021 · External reference
Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer’s disease.
10.3389/fnagi.2022.932676 · 2022 · External reference
Machine learning screening for Parkinson’s disease-related cuproptosis-related typing development and validation and exploration of personalized drugs for cuproptosis genes
10.21037/atm-22-5756 · 2023 · External reference
Identification of Cuproptosis Clusters and Integrative Analyses in Parkinson’s Disease
10.3390/brainsci13071015 · 2023 · External reference
Identification of Key Genes and Immunological Features Associated with Copper Metabolism in Parkinson’s Disease by Bioinformatics Analysis
External reference
NCBI GEO: mining millions of expression profiles—database and tools
10.1093/nar/gki022 · 2005 · External reference
Cuproptosis Combined with lncRNAs Predicts the Prognosis and Immune Microenvironment of Breast Cancer
10.1155/2022/5422698 · 2022 · External reference
STRING v10: protein-protein interaction networks, integrated over the tree of life
10.1093/nar/gku1003 · 2015 · External reference
Unresolved reference
2005 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
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10.1016/j.biosystems.2014.11.005 · 2015 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
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10.1038/75556 · 2000 · External reference
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10.1093/nar/28.1.27 · 2000 · External reference
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10.1089/omi.2011.0118 · 2012 · External reference
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10.1186/1471-2105-12-77 · 2011 · External reference
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
10.1093/nar/gkq537 · 2010 · External reference
HMDD v3.0: a database for experimentally supported human microRNA-disease associations
10.1093/nar/gky1010 · 2019 · External reference
miRWalk: An online resource for prediction of microRNA binding sites.
10.1371/journal.pone.0206239 · 2018 · External reference
DIANA-miRPath v3.0: deciphering microRNA function with experimental support
10.1093/nar/gkv403 · 2015 · External reference
Copper and copper proteins in Parkinson’s disease
10.1155/2014/147251 · 2014 · External reference
Copper Ions and Parkinson’s Disease: Why Is Homeostasis So Relevant?
10.3390/biom10020195 · 2020 · External reference
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease.
10.1084/jem.20112285 · 2012 · External reference
Meta-Analysis of Copper and Iron in Parkinson’s Disease Brain and Biofluids
10.1002/mds.27947 · 2020 · External reference
Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.
10.1165/rcmb.2013-0238oc · 2014 · External reference
Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence
10.1186/s13058-014-0497-4 · 2014 · External reference
Blood Markers of Inflammation, Neurodegeneration, and Cardiovascular Risk in Early Parkinson’s Disease
10.1002/mds.29257 · 2023 · External reference
A novel interaction between aging and ER overload in a protein conformational dementia
10.1534/genetics.112.149088 · 2013 · External reference
Endoplasmic reticulum dysfunction in neurological disease
10.1016/s1474-4422(12)70238-7 · 2013 · External reference
Serpin Signatures in Prion and Alzheimer’s Diseases
10.1007/s12035-022-02817-3 · 2022 · External reference
Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease
10.1074/jbc.m600690200 · 2006 · External reference
Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzheimer’s disease transgenic mouse model
10.1111/j.1471-4159.2011.07359.x · 2011 · External reference
Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking
10.1016/j.neuron.2021.10.032 · 2022 · External reference
Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema
10.1165/rcmb.2017-0361oc · 2018 · External reference
Predicting the potential human lncRNA-miRNA interactions based on graph convolution network with conditional random field
10.1093/bib/bbac463 · 2022 · External reference
Using Network Distance Analysis to Predict lncRNA-miRNA Interactions.
10.1007/s12539-021-00458-z · 2021 · External reference
Gene function and cell surface protein association analysis based on single-cell multiomics data
10.1016/j.compbiomed.2023.106733 · 2023 · External reference
Predicting metabolite-disease associations based on auto-encoder and non-negative matrix factorization
10.1093/bib/bbad259 · 2023 · External reference
A deep learning method for predicting metabolite-disease associations via graph neural network
10.1093/bib/bbac266 · 2022 · External reference
DCAMCP: A deep learning model based on capsule network and attention mechanism for molecular carcinogenicity prediction
10.1111/jcmm.17889 · 2023 · External reference
Investigating cardiotoxicity related with hERG channel blockers using molecular fingerprints and graph attention mechanism
10.1016/j.compbiomed.2022.106464 · 2023 · External reference
scAAGA: Single cell data analysis framework using asymmetric autoencoder with gene attention
10.1016/j.compbiomed.2023.107414 · 2023 · External reference
Differential expression and significance of miRNAs in plasma extracellular vesicles of patients with Parkinson’s disease
10.1080/00207454.2020.1835899 · 2022 · External reference
Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CREB Signaling.
10.3390/nu15040972 · 2023 · External reference
RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes
10.1007/s13238-020-00810-x · 2021 · External reference
Specificity and competition of mRNAs dominate droplet pattern in protein phase separation.
2023 · External reference
Quantifying the underlying landscape, entropy production and biological path of the cell fate decision between apoptosis and pyroptosis
10.1016/j.chaos.2023.114328 · 2024 · External reference
