Research graph
References from A comprehensive analysis of ribonucleotide reductase subunit M2 for carcinogenesis in pan-cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Therapeutic targeting of tumor suppressor genes
10.1002/cncr.29140 · 2015 · External reference
Comprehensive characterization of the alternative splicing landscape in head and neck squamous cell carcinoma reveals novel events associated with tumorigenesis and the immune microenvironment
10.7150/thno.36585 · 2019 · External reference
Immune checkpoint proteins: a new therapeutic paradigm for cancer—preclinical background: CTLA-4 and PD-1 blockade
2010 · External reference
Immune infiltration in human tumors: a prognostic factor that should not be ignored
10.1038/onc.2009.416 · 2010 · External reference
Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
10.1093/nar/gkq829 · 2011 · External reference
The lncRNA lincNMR regulates nucleotide metabolism via a YBX1—RRM2 axis in cancer.
10.1038/s41467-020-17007-9 · 2020 · External reference
A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2).
10.1158/1078-0432.ccr-18-4046 · 2019 · External reference
siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin
10.1016/j.omtn.2018.08.003 · 2018 · External reference
Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
10.1186/s12943-021-01393-9 · 2021 · External reference
RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer
10.1186/s12935-020-01689-8 · 2020 · External reference
RRM2 is a potential prognostic biomarker with functional significance in glioma
10.7150/ijbs.30114 · 2019 · External reference
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma
10.18632/aging.202292 · 2020 · External reference
Targeting RRM2 and Mutant BRAF Is a Novel Combinatorial Strategy for Melanoma
10.1158/1541-7786.mcr-16-0099 · 2016 · External reference
LncRNA AFAP1-AS1 Supresses miR-139-5p and Promotes Cell Proliferation and Chemotherapy Resistance of Non-small Cell Lung Cancer by Competitively Upregulating RRM2.
10.3389/fonc.2019.01103 · 2019 · External reference
BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.
10.1038/ncomms13398 · 2016 · External reference
The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors
10.1038/s41388-020-01552-0 · 2021 · External reference
DHS (trans-4,4’-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2).
10.1038/s41388-018-0584-6 · 2019 · External reference
Visualizing and interpreting cancer genomics data via the Xena platform
10.1038/s41587-020-0546-8 · 2020 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
10.1186/s13073-017-0424-2 · 2017 · External reference
Classification and characterization of microsatellite instability across 18 cancer types
10.1038/nm.4191 · 2016 · External reference
TIMER2.0 for analysis of tumor-infiltrating immune cells
10.1093/nar/gkaa407 · 2020 · External reference
The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies.
10.3389/fimmu.2020.00784 · 2020 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
jvenn: an interactive Venn diagram viewer
10.1186/1471-2105-15-293 · 2014 · External reference
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics
2020 · External reference
Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape
10.1186/s40425-019-0667-0 · 2019 · External reference
The dark side of tumor-associated endothelial cells.
10.1016/j.smim.2018.02.002 · 2018 · External reference
Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition
10.1038/s41388-020-01403-y · 2020 · External reference
EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness
10.1038/s41416-019-0538-y · 2019 · External reference
RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia
10.1182/blood-2011-11-382226 · 2012 · External reference
RRM1 and ERCC1 as biomarkers in patients with locally advanced and metastatic malignant pleural mesothelioma treated with continuous infusion of low-dose gemcitabine plus cisplatin
10.1186/s12885-021-08287-5 · 2021 · External reference
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
10.1093/nar/gkz430 · 2019 · External reference
Expression of Genomic Instability-Related Molecules: Cyclin F, RRM2 and SPDL1 and Their Prognostic Significance in Pancreatic Adenocarcinoma.
10.3390/cancers13040859 · 2021 · External reference
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
10.1056/nejmra1703481 · 2018 · External reference
RRM2 Regulates Sensitivity to Sunitinib and PD-1 Blockade in Renal Cancer by Stabilizing ANXA1 and Activating the AKT Pathway.
10.1002/advs.202100881 · 2021 · External reference
Cell cycle dependent RRM2 may serve as proliferation marker and pharmaceutical target in adrenocortical cancer.
2016 · External reference
Independent prognostic implications of RRM2 in lung adenocarcinoma
10.7150/jca.47895 · 2020 · External reference
Identification and validation of three core genes in p53 signaling pathway in hepatitis B virus-related hepatocellular carcinoma.
10.1186/s12957-021-02174-w · 2021 · External reference
Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
10.1016/j.celrep.2022.111396 · 2022 · External reference
Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis
10.1016/j.bcp.2019.04.022 · 2019 · External reference
Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer
10.1186/s13046-014-0102-9 · 2014 · External reference