Research graph
References from LEDT and Idebenone treatment modulate autophagy and improve regenerative capacity in the dystrophic muscle through an AMPK-pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
The muscular dystrophies
10.1016/s0140-6736(02)07815-7 · 2002 · External reference
Duchenne muscular dystrophy and caregiver burden: a systematic review
10.1111/dmcn.13934 · 2018 · External reference
Wasting mechanisms in muscular dystrophy.
10.1016/j.biocel.2013.05.001 · 2013 · External reference
Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: Past, present, and future.
10.1007/s43440-020-00134-x · 2020 · External reference
Ion Channel of the sarcolemma and intracellular and intracellular organelles in duchenne muscular dystrophy: a role in the dysregulation of ion homeostasis and a possible target for therapy
10.3390/ijms24032229 · 2023 · External reference
X chromosome-linked muscular dystrophy (mdx) in the mouse.
10.1073/pnas.81.4.1189 · 1984 · External reference
Fiber regeneration is not persistent in dystrophic (MDX) mouse skeletal muscle.
10.1016/0012-1606(91)90340-9 · 1991 · External reference
Autophagy as a new therapeutic target in Duchenne muscular dystrophy.
10.1038/cddis.2012.159 · 2012 · External reference
AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm
10.1016/j.ajpath.2012.04.004 · 2012 · External reference
Deficit in PINK1/PARKIN-mediated mitochondrial autophagy at late stages of dystrophic cardiomyopathy
10.1093/cvr/cvx201 · 2018 · External reference
Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.
10.1155/2018/9179270 · 2018 · External reference
Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles
10.1038/cdd.2016.70 · 2016 · External reference
The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases
10.3390/ijms24010297 · 2022 · External reference
MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway.
10.1038/s41419-020-02756-8 · 2020 · External reference
Practice guideline update summary: corticosteroid treatment of Duchenne muscular dystrophy: Report of the Guideline Development Subcommittee of the American Academy of Neurology
10.1212/wnl.0000000000002337 · 2022 · External reference
Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis.
10.1007/s10103-017-2368-6 · 2018 · External reference
Pre-conditioning with low-level laser (light) therapy: light before the storm.
10.2203/dose-response.14-032.agrawal · 2014 · External reference
The pulse light mode enhances the effect of photobiomodulation on B16F10 melanoma cells through autophagy pathway
10.1007/s10103-023-03733-1 · 2023 · External reference
Effects of photobiomodulation therapy on regulation of myogenic regulatory factor mRNA expression in vivo: A systematic review
10.1002/jbio.202100219 · 2022 · External reference
Pre-exercise low-level laser therapy improves performance and levels of oxidative stress markers in mdx mice subjected to muscle fatigue by high-intensity exercise
10.1007/s10103-015-1777-7 · 2015 · External reference
Photobiomodulation therapy for attenuating the dystrophic phenotype of Mdx mice
10.1111/php.13179 · 2020 · External reference
Protection of dystrophic muscle cells using Idebenone correlates with the interplay between calcium, oxidative stress and inflammation
10.1111/iep.12463 · 2023 · External reference
Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice.
10.1038/s41420-022-00826-8 · 2022 · External reference
LED therapy plus idebenone treatment targeting calcium and mitochondrial signaling pathways in dystrophic muscle cells
2023 · External reference
Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy
10.1083/jcb.125.6.1275 · 1994 · External reference
Coenzyme Q10 supplementation acts as antioxidant on dystrophic muscle cells
10.1007/s12192-019-01039-2 · 2019 · External reference
Cross-talk between TRPC-1, mTOR, PGC-1α and PPARδ in the dystrophic muscle cells treated with tempol
10.1080/10715762.2022.2074842 · 2022 · External reference
Multiple LEDT wavelengths modulate the Akt signaling pathways and attenuate pathological events in mdx dystrophic muscle cells.
10.1007/s43630-022-00216-0 · 2022 · External reference
Oxidative stress, inflammation, and activators of mitochondrial biogenesis: tempol targets in the diaphragm muscle of exercise trained-mdx mice.
10.3389/fphys.2021.649793 · 2021 · External reference
Effect of low-level laser therapy in the myonecrosis induced by Bothrops jararacussu snake venom.
10.1089/pho.2008.2296 · 2009 · External reference
Non-invasive biomarkers for duchenne muscular dystrophy and carrier detection.
10.3390/molecules200611154 · 2015 · External reference
Antioxidant effects of bis-indole alkaloid indigo and related signaling pathways in the experimental model of Duchenne muscular dystrophy
10.1007/s12192-022-01282-0 · 2022 · External reference
The mutant mdx: inherited myopathy in the mouse. Morphological studies of nerves, muscles and end-plates
10.1093/brain/110.2.269 · 1987 · External reference
Histological parameters for the quantitative assessment of muscular dystrophy in the mdx-mouse
10.1016/j.nmd.2004.06.008 · 2004 · External reference
Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice hearts at later stages of dystrophy.
10.1016/j.nut.2016.01.015 · 2016 · External reference
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
10.1093/emboj/19.21.5720 · 2000 · External reference
Monitoring autophagic degradation of p62/SQSTM1
10.1016/s0076-6879(08)03612-4 · 2009 · External reference
Function of the myogenic regulatory actors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, sarellite cells and regenerative myogenesis.
10.1016/j.semcdb.2017.11.011 · 2017 · External reference
The Role of Autophagy in Skeletal Muscle Diseases.
10.3389/fphys.2021.638983 · 2021 · External reference
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway
10.3389/fphar.2022.991421 · 2022 · External reference
Role of AMPK in autophagy.
10.3389/fphys.2022.1015500 · 2022 · External reference
The association of AMPK with ULK1 regulates autophagy.
10.1371/journal.pone.0015394 · 2010 · External reference
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
10.1126/science.1196371 · 2011 · External reference
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
10.1038/ncb2152 · 2011 · External reference
TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.
10.1101/gad.925901 · 2001 · External reference
TGF-beta’s delay skeletal muscle progenitor cell differentiation in an isoform-independent manner
10.1016/j.yexcr.2008.10.037 · 2009 · External reference
Nuclear factor-kappa B signaling in skeletal muscle atrophy
10.1007/s00109-008-0373-8 · 2008 · External reference
Accelerated burn wound healing with photobiomodulation therapy involves activation of endogenous latent TGF-β1.
10.1038/s41598-021-92650-w · 2021 · External reference
Exploring the ability of low-level laser irradiation to reduce myonecrosis and increase Myogenin transcription after Bothrops jararacuçu envenomation.
10.1007/s43630-021-00041-x · 2021 · External reference
Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy
10.1016/0092-8674(88)90463-1 · 1988 · External reference
Acute, next-generation AMPK activation initiates a disease-resistant gene expression program in dystrophic skeletal muscle
10.1096/fj.202201846rr · 2023 · External reference
Amp-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in duchenne muscular dystrophy
10.1016/j.molmed.2013.07.002 · 2013 · External reference
The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
10.3390/ijms19103125 · 2018 · External reference
