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References from Serum levels of matrix metalloproteinases 1, 2, and 7, and their tissue inhibitors 1, 2, 3, and 4 in polytraumatized patients: Time trajectories, correlations, and their ability to predict mortality. Local targets link to admitted publications; unresolved targets remain external evidence.
Global changes in mortality rates in polytrauma patients admitted to the ICU—a systematic review
10.1186/s13017-020-00330-3 · 2020 · External reference
Pathophysiology in patients with polytrauma
10.1016/j.injury.2022.04.009 · 2022 · External reference
Matrix metalloproteinases: regulation and dysregulation in the failing heart
10.1161/01.res.0000013290.12884.a3 · 2002 · External reference
Role of Matrix Metalloproteinases in Angiogenesis and Cancer
10.3389/fonc.2019.01370 · 2019 · External reference
Matrix metalloproteinase profiling and their roles in disease
10.1039/d2ra07005g · 2023 · External reference
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
2020 · External reference
Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: an immunohistochemical study
10.5604/00306657.1202546 · 2016 · External reference
Series "matrix metalloproteinases in lung health and disease": Biological role of matrix metalloproteinases: a critical balance
10.1183/09031936.00146510 · 2011 · External reference
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
10.3109/14756366.2016.1161620 · 2016 · External reference
Collagenases MMP-1, MMP-13, and Tissue Inhibitors TIMP-1, TIMP-2: Their Role in Healthy and Complicated Pregnancy and Potential as Preeclampsia Biomarkers—A Brief Review
10.3390/app10217731 · 2020 · External reference
Matrix metalloproteases and PAR1 activation
10.1182/blood-2012-09-355958 · 2013 · External reference
Suppressed Expression but Not Activity of Collagenases MMP-1 and MMP-13 in Human Renal Carcinoma
10.1159/000499499 · 2019 · External reference
3rd, Walsh SW. Increased expression of matrix metalloproteinase-1 in systemic vessels of preeclamptic women: a critical mediator of vascular dysfunction
10.1016/j.ajpath.2010.11.003 · 2011 · External reference
The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation
2016 · External reference
Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions
10.1002/jcp.25430 · 2016 · External reference
Release of gelatinase A during platelet activation mediates aggregation
10.1038/386616a0 · 1997 · External reference
Role of Gelatinases MMP-2 and MMP-9 in Healthy and Complicated Pregnancy and Their Future Potential as Preeclampsia Biomarkers
2021 · External reference
Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion
10.5395/rde.2020.45.e31 · 2020 · External reference
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted
10.1152/physrev.00022.2006 · 2007 · External reference
Distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers
10.1152/ajpcell.00113.2019 · 2019 · External reference
MMP-2 and TIMP-2 in Patients with Heart Failure and Chronic Kidney Disease
10.1515/med-2018-0037 · 2018 · External reference
Roles of matrix metalloproteinase-7 (MMP-7) in cancer
10.1016/j.clinbiochem.2021.03.003 · 2021 · External reference
The role of matrix metalloproteinase 7 in innate immunity
10.1016/j.imbio.2004.04.005 · 2004 · External reference
MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices
10.1242/jcs.02360 · 2005 · External reference
Control of matrix metalloproteinase catalytic activity
10.1016/j.matbio.2007.07.001 · 2007 · External reference
Matrix metalloproteinase-7 is increased in lung bases but not apices in idiopathic pulmonary fibrosis
10.1183/23120541.00191-2022 · 2022 · External reference
Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification
10.1073/pnas.1515397113 · 2016 · External reference
Matrix metalloproteinases in urinary system tumours. Part I—Matrix metalloproteinases in renal cell carcinoma
2017 · External reference
Matrix metalloproteinases
10.1074/jbc.274.31.21491 · 1999 · External reference
Metalloproteinase inhibitors: biological actions and therapeutic opportunities
10.1242/jcs.00063 · 2002 · External reference
Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes
10.1371/journal.pone.0075836 · 2013 · External reference
TIMPs: versatile extracellular regulators in cancer
10.1038/nrc.2016.115 · 2017 · External reference
The role of TIMPs in regulation of extracellular matrix proteolysis
10.1016/j.matbio.2015.03.005 · 2015 · External reference
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring.
10.1089/wound.2013.0485 · 2015 · External reference
Identification of TIMP-2 in human alveolar macrophages. Regulation of biosynthesis is opposite to that of metalloproteinases and TIMP-1
10.1016/s0021-9258(19)49652-x · 1992 · External reference
Tissue inhibitor of metalloproteinase-2 (TIMP-2) location in the ventral, lateral, dorsal and anterior lobes of rat prostate by immunohistochemistry
10.1016/j.cellbi.2006.10.004 · 2007 · External reference
Interaction of keratinocytes and fibroblasts modulates the expression of matrix metalloproteinases-2 and -9 and their inhibitors
10.1007/s11010-005-3178-x · 2005 · External reference
Differential expression of tissue inhibitors of metalloproteinases (TIMP-1, -2, -3, and -4) in normal and aberrant wound healing
10.1016/s0046-8177(99)90140-5 · 1999 · External reference
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations
1998 · External reference
Mesenchymal stem cells regulate blood-brain barrier integrity through TIMP3 release after traumatic brain injury
10.1126/scitranslmed.3004660 · 2012 · External reference
Oxidised, glycated LDL selectively influences tissue inhibitor of metalloproteinase-3 gene expression and protein production in human retinal capillary pericytes
10.1007/s00125-007-0768-z · 2007 · External reference
Adipocyte extracellular matrix composition, dynamics and role in obesity
10.1007/s00018-010-0263-4 · 2010 · External reference
Endometrial TIMP-4 mRNA is expressed in the stroma, while TIMP-4 protein accumulates in the epithelium and is released to the uterine fluid
10.1093/molehr/gal055 · 2006 · External reference
Selected Matrix Metalloproteinases (MMP-2, MMP-7) and Their Inhibitor (TIMP-2) in Adult and Pediatric Cancer
2020 · External reference
MMP-1 is overexpressed in triple-negative breast cancer tissues and the knockdown of MMP-1 expression inhibits tumor cell malignant behaviors in vitro
2019 · External reference
Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases Ratio: A Biomarker of Bone Resorption in Geriatric Osteoporosis?
10.4235/agmr.23.0024 · 2023 · External reference
Role of Matrix Metalloproteinases in Musculoskeletal Diseases
10.3390/biomedicines10102477 · 2022 · External reference
Usefulness of tissue inhibitor of metalloproteinase 1 as a predictor of sustained remission in patients with antineutrophil cytoplasmic antibody-associated vasculitis
10.1186/s13075-021-02471-5 · 2021 · External reference
Matrix Metalloproteinases and Their Tissue Inhibitors: an Evaluation of Novel Biomarkers in ANCA-Associated Vasculitis
10.14712/fb2019065050227 · 2019 · External reference
MMP 1 circulating levels and promoter polymorphism in risk prediction of coronary artery disease in asymptomatic first degree relatives
10.1016/j.gene.2016.09.041 · 2016 · External reference
Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study
10.1186/s12933-017-0539-1 · 2017 · External reference
Evaluation of the Efficiency of TIMP-2 as a Biomarker for Acute Kidney Injury in Sepsis
10.1007/s10517-023-05791-5 · 2023 · External reference
Unbiased Human Kidney Tissue Proteomics Identifies Matrix Metalloproteinase 7 as a Kidney Disease Biomarker
10.1681/asn.0000000000000141 · 2023 · External reference
Molecular Markers of Early Immune Response in Tuberculosis: Prospects of Application in Predictive Medicine
10.3390/ijms241713261 · 2023 · External reference
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Are Potential Biomarkers of Pulmonary and Extra-Pulmonary Tuberculosis
10.3389/fimmu.2020.00419 · 2020 · External reference
Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease
10.1186/1471-2172-14-9 · 2013 · External reference
The role of matrix metalloproteinases in patients with pulmonary hypertension: data from a prospective study
10.1186/s12872-021-02424-5 · 2021 · External reference
Cytokine profiles and virological markers highlight distinctive immune statuses, and effectivenesses and limitations of NAs across different courses of chronic HBV infection
10.1016/j.cyto.2023.156442 · 2024 · External reference
Biomarkers of axonal damage to favor early diagnosis in variant transthyretin amyloidosis (A-ATTRv)
10.1038/s41598-023-50212-2 · 2024 · External reference
Detection and activity of MMP-2 and MMP-9 in Leishmania amazonensis and Leishmania braziliensis promastigotes
10.1186/s12866-023-02973-z · 2023 · External reference
Changes in serum blood-brain barrier markers after bilateral tonic-clonic seizures
10.1016/j.seizure.2023.02.012 · 2023 · External reference
Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing
10.1111/j.1464-5491.2008.02414.x · 2008 · External reference
The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection
10.1186/s12876-023-02923-z · 2023 · External reference
The Imbalance of MMP-2/TIMP-2 and MMP-9/TIMP-1 Contributes to Collagen Deposition Disorder in Diabetic Non-Injured Skin.
10.3389/fendo.2021.734485 · 2021 · External reference
MMPs and TIMPs levels are correlated with anthropometric parameters, blood pressure, and endothelial function in obesity
10.1038/s41598-021-99577-2 · 2021 · External reference
Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy
10.1186/s13195-023-01171-3 · 2023 · External reference
Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury
10.1186/1471-2377-7-17 · 2007 · External reference
Blood-brain barrier dysfunction significantly correlates with serum matrix metalloproteinase-7 (MMP-7) following traumatic brain injury
10.1016/j.nicl.2021.102741 · 2021 · External reference
Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury
10.1371/journal.pone.0094370 · 2014 · External reference
Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients
10.1016/j.jcrc.2019.02.014 · 2019 · External reference
Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury
10.1136/tsaco-2018-000171 · 2018 · External reference
Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with moderate and severe traumatic brain injury
10.4103/0028-3886.125258 · 2013 · External reference
Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period
10.1155/2020/4936374 · 2020 · External reference
Influence of massive blood transfusion and traumatic brain injury on TIMP‑1 and MMP‑9 serum levels in polytraumatized patients
2019 · External reference
Calculating correlation coefficients with repeated observations: Part 1—Correlation within subjects
10.1136/bmj.310.6977.446 · 1995 · External reference
Index for rating diagnostic tests
10.1002/1097-0142(1950)3:1<32::aid-cncr2820030106>3.0.co;2-3 · 1950 · External reference
Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period
10.1155/2012/435463 · 2012 · External reference
Neutrophil Gene Expression Patterns in Multiple Trauma Patients Indicate Distinct Clinical Outcomes
10.1016/j.jss.2022.03.011 · 2022 · External reference
Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients
10.1016/j.jcrc.2019.02.014 · 2019 · External reference
Circulating TIMP-1 is associated with hematoma volume in patients with spontaneous intracranial hemorrhage
10.1038/s41598-020-67250-9 · 2020 · External reference
TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin β 1 complex and regulating downstream FAK/RhoA signaling
10.1016/j.apsb.2020.02.015 · 2020 · External reference
Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1
10.1089/neu.2009.0959 · 2009 · External reference
Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study
2016 · External reference
Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study
10.1007/s13311-019-00735-2 · 2019 · External reference
Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study
10.1155/2018/9387809 · 2018 · External reference
Exploration of Predictive Biomarkers of Early Infliximab Response in Acute Severe Colitis: A Prospective Pilot Study
10.1093/ecco-jcc/jjx146 · 2018 · External reference
Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study
10.1111/jcmm.14671 · 2020 · External reference
Impact of Polytrauma and Acute Respiratory Distress Syndrome on Markers of Fibrinolysis: A Prospective Pilot Study
10.3389/fmed.2020.00194 · 2020 · External reference