Research graph
References from AP39, a novel mitochondria-targeted hydrogen sulfide donor ameliorates doxorubicin-induced cardiotoxicity by regulating the AMPK/UCP2 pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
A systematic analysis of FDA-approved anticancer drugs.
10.1186/s12918-017-0464-7 · 2017 · External reference
The role of cardioprotection in cancer therapy cardiotoxicity: JACC: cardiooncology state-of-the-art review.
10.1016/j.jaccao.2022.01.101 · 2022 · External reference
Pegylated and liposomal doxorubicin is associated with high mortality and causes limited cardiotoxicity in mice.
10.1186/s13104-018-3260-6 · 2018 · External reference
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management.
10.1016/j.biopha.2021.111708 · 2021 · External reference
Doxorubicin-induced cardiotoxicity: causative factors and possible interventions
10.1093/jpp/rgac063 · 2022 · External reference
Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity.
10.1016/j.biopha.2017.04.033 · 2017 · External reference
Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate.
10.3389/fphar.2019.00635 · 2019 · External reference
Use of Cardioprotective Dexrazoxane Is Associated with Increased Myelotoxicity in Anthracycline- Treated Soft-Tissue Sarcoma Patients.
10.1159/000501195 · 2019 · External reference
Hydrogen sulfide: A new therapeutic target in vascular diseases.
External reference
Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.
2020 · External reference
Effect of hydrogen sulfide on cardiomyocyte apoptosis in rats with myocardial ischemia-reperfusion injury via the JNK signaling pathway.
2020 · External reference
Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice
10.1161/circulationaha.109.920991 · 2010 · External reference
Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats.
10.1089/ars.2012.4888 · 2014 · External reference
Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6/AMPK Autophagy.
10.3389/fphar.2020.01150 · 2020 · External reference
Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway
10.3892/mmr.2020.11291 · 2020 · External reference
Gaseous signaling molecules in cardiovascular function: from mechanisms to clinical translation
10.1007/112_2017_7 · 2018 · External reference
The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases.
10.3390/ijms22042194 · 2021 · External reference
AP39, a mitochondria-targeting hydrogen sulfide (H(2) S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling[J].
10.1111/bph.13688 · 2017 · External reference
AP39[10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl) phenoxy) decyl) triphenylphosphonium bromide], a mitochondrially targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.
10.1016/j.niox.2014.04.008 · 2014 · External reference
AP39, a mitochondria-targeting hydrogen sulfide (H2 S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling.
10.1111/bph.13688 · 2017 · External reference
AP39 inhibits ferroptosis by inhibiting mitochondrial autophagy through the PINK1/parkin pathway to improve myocardial fibrosis with myocardial infarction
10.1016/j.biopha.2023.115195 · 2023 · External reference
Supplementing preservation solution with mitochondria-targeted H2 S donor AP39 protects cardiac grafts from prolonged cold ischemia-reperfusion injury in heart transplantation
10.1111/ajt.15539 · 2019 · External reference
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
10.1038/ncb2152 · 2011 · External reference
Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE
10.1016/j.freeradbiomed.2019.07.001 · 2019 · External reference
AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis
10.1016/j.freeradbiomed.2018.08.032 · 2018 · External reference
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice.
10.3389/fphar.2022.1038802 · External reference
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
10.1007/s10557-020-06941-x · 2020 · External reference
Hydrogen Sulfide Regulates Cardiac Mitochondrial Biogenesis via the Activation of AMPK
10.1016/j.yjmcc.2018.01.011 · 2018 · External reference
An Update on AMPK in Hydrogen Sulfide Pharmacology.
10.3389/fphar.2017.00810 · 2017 · External reference
Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway.
10.1016/j.jare.2022.07.002 · 2023 · External reference
AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons.
10.1155/2016/8360738 · 2016 · External reference
Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1alpha signaling contributing to increased vulnerability in diabetic heart
10.1007/s00395-013-0329-1 · 2013 · External reference
Genipin inhibits the inflammatory response of rat brain microglial cells
10.1016/j.intimp.2010.01.011 · 2010 · External reference
LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/ Sirt1 pathway
10.3748/wjg.v25.i45.6607 · External reference
Molecular basis of anthracycline-induced cardiotoxicity and its prevention
10.1006/mgme.2000.3043 · 2000 · External reference
New signal transduction paradigms in anthracycline- induced cardiotoxicity, Biochim
10.1016/j.bbamcr.2016.01.021 · 2016 · External reference
Cardiotoxicity of anticancer treatments: epidemiology, detection, and management
10.3322/caac.21341 · 2016 · External reference
Anthracycline cardiotoxicity: from bench to bedside.
10.1200/jco.2007.14.9401 · 2008 · External reference
Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats. Journal of Applied Toxicology
External reference
Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats.
10.1016/j.fct.2010.01.005 · External reference
10.21037/cdt-19-707
10.21037/cdt-19-707 · External reference
10.1016/s0022-2828(03)00229-3
10.1016/s0022-2828(03)00229-3 · External reference
10.1016/j.bbrc.2020.09.035
10.1016/j.bbrc.2020.09.035 · External reference
The biosynthesis and functional role of cardiolipin, Prog.
10.1016/s0163-7827(00)00005-9 · 2000 · External reference
10.1161/01.cir.0000093196.59829.df
10.1161/01.cir.0000093196.59829.df · External reference
10.1016/j.taap.2010.01.006
10.1016/j.taap.2010.01.006 · External reference
10.1016/j.jacbts.2016.10.006 · Admitted local publication
Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis.
10.1007/s00280-017-3413-7 · 2017 · External reference
Metformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: an in vitro study.
10.1371/journal.pone.0104888 · 2014 · External reference
Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction
10.1073/pnas.1006965107 · 2010 · External reference
Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.
10.1152/physrev.00017.2011 · 2012 · External reference
Hydrogen sulphide and its therapeutic potential.
10.1038/nrd2425 · 2007 · External reference
Novel insights into hydrogen sulfide-mediated cytoprotection.
10.1089/ars.2009.2882 · 2010 · External reference
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
10.1073/pnas.0705891104 · 2007 · External reference
Hydrogen sulfide inhibits high-glucose-induced apoptosis in neonatal rat cardiomyocytes.
10.1177/1535370213477989 · 2013 · External reference
AP39 ameliorates high fat diet-induced liver injury in young rats via alleviation of oxidative stress and mitochondrial impairment.
10.1538/expanim.21-0056 · 2021 · External reference
Transdermal delivery of mitochondrial-targeted hydrogen sulphide donor, AP39 protects against 6-hydroxydopamine-induced mitochondrial dysfunction.
2023 · External reference
Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain.
10.1113/jphysiol.2006.110122 · 2006 · External reference
Acute toxicity of doxorubicin on isolated perfused heart: Response of kinases regulating energy supply.
2005 · External reference
Inhibition of AMPK signalling by doxorubicin: At the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress
10.1093/cvr/cvs134 · 2012 · External reference
Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation
10.1093/cvr/cvq335 · 2011 · External reference
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.
10.1007/s10557-020-06941-x · 2020 · External reference
Uncoupling Protein 2 as a Pathogenic Determinant and Therapeutic Target in Cardiovascular and Metabolic Diseases.
10.2174/1570159x19666210421094204 · 2022 · External reference
Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease.
10.1155/2016/1067801 · 2016 · External reference
Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes.
10.1161/01.res.0000085581.60197.4d · 2003 · External reference
Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke.
10.1038/jcbfm.2009.4 · 2009 · External reference
UCP2 protect the heart from myocardial ischemia/reperfusion injury via induction of mitochondrial autophagy
10.1002/jcb.28812 · 2019 · External reference
The effects of UCP2 on autophagy through the AMPK signaling pathway in septic cardiomyopathy and the underlying mechanism.
10.21037/atm-20-4819 · 2021 · External reference
UCP2 regulates cholangiocarcinoma cell plasticity via mitochondria-to-AMPK signals.
10.1016/j.bcp.2019.05.017 · 2019 · External reference
Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway
10.1016/j.toxlet.2015.01.021 · 2015 · External reference
