Research graph
References from Clodronate disodium does not produce measurable effects on bone metabolism in an exercising, juvenile, large animal model. Local targets link to admitted publications; unresolved targets remain external evidence.
Fifty years of bisphosphonates: What are their mechanical effects on bone?
10.1016/j.bone.2020.115518 · 2020 · External reference
Pharmacology of bisphosphonates
10.1111/bcp.13867 · 2019 · External reference
Bisphosphonates: Mode of action and pharmacology
10.1542/peds.2006-2023h · 2007 · External reference
Bisphosphonates: A review of their pharmacokinetic properties
10.1016/8756-3282(95)00445-9 · 1996 · External reference
Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates
10.1007/s00223-002-2066-6 · 2003 · External reference
Potential usefulness of bmd and bone turnover monitoring of zoledronic acid therapy among women with osteoporosis: Secondary analysis of randomized controlled trial data
10.1002/jbmr.2847 · 2016 · External reference
Five years of anti-resorptive activity after a single dose of zoledronate–results from a randomized double-blind placebo-controlled trial
10.1016/j.bone.2012.03.016 · 2012 · External reference
Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate
10.1016/j.bone.2006.04.028 · 2006 · External reference
Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles
10.1016/s8756-3282(01)00414-8 · 2001 · External reference
Benefits and risks of bisphosphonate therapy for osteoporosis
10.1210/jc.2012-1027 · 2012 · External reference
Review Denosumab vs bisphosphonates for the treatment of postmenopausal osteoporosis
10.1530/eje-18-0056 · 2018 · External reference
High levels of serum prostaglandin E2 in children with osteogenesis imperfecta are reduced by neridronate treatment
10.1203/pdr.0b013e31815efd63 · 2008 · External reference
Cyclic bisphosphonate therapy reduces pain and improves physical functioning in children with osteogenesis imperfecta
10.1186/s12891-018-2252-y · 2018 · External reference
Effects of bisphosphonates in children with osteogenesis imperfecta: an AACPDM systematic review.
10.1111/j.1469-8749.2008.03222.x · 2009 · External reference
Efficacy of zoledronic acid treatment in Paget disease of bone
10.1007/s00198-014-2752-z · 2014 · External reference
Comparative responses of bone turnover markers to bisphosphonate therapy in Paget’s disease of bone
10.1016/j.bone.2004.03.023 · 2004 · External reference
Use of the bisphosphonate drug alendronate for palliative management of osteosarcoma in two dogs
10.1136/vr.147.5.129 · 2000 · External reference
Use of bisphosphonates to treat severe idiopathic hypercalcaemia in a young Ragdoll cat.
10.1016/j.jfms.2010.09.011 · 2011 · External reference
Clinical efficacy of clodronic acid in horses diagnosed with navicular syndrome: A field study using objective and subjective lameness evaluation
10.1016/j.rvsc.2019.07.018 · 2019 · External reference
Tiludronate as a new therapeutic agent in the treatment of navicular disease: a double-blind placebo-controlled clinical trial
10.2746/042516403776014226 · 2003 · External reference
Adolescents and bone health
10.1097/grf.0000000000000548 · 2020 · External reference
The female athlete triad.
10.1177/1941738112439685 · 2012 · External reference
The male athlete triad–a consensus statement from the female and male athlete triad coalition part II: diagnosis, treatment, and return-to-play.
10.1097/jsm.0000000000000948 · 2021 · External reference
Bisphosphonates in veterinary medicine: The new horizon for use
10.1016/j.bone.2020.115711 · 2021 · External reference
Is the use of bisphosphonates putting horses at risk? An osteoclast perspective
10.3390/ani12131722 · 2022 · External reference
Retrospective analysis of the use of tiludronate in equine practice: safety on 1804 horses, efficacy on 343 horses.
2022 · External reference
Unresolved reference
External reference
Bisphosphonate use in the horse: What is good and what is not?
10.1186/s12917-019-1966-x · 2019 · External reference
Bone modeling and remodeling: Potential as therapeutic targets for the treatment of osteoporosis
10.1177/1759720x16670154 · 2016 · External reference
Abundant osteoclasts in the subchondral bone of the juvenile Thoroughbred metacarpus suggest an important role in joint maturation
10.1111/evj.13235 · 2020 · External reference
10.1016/b978-0-12-813259-3.00005-1
10.1016/b978-0-12-813259-3.00005-1 · 2019 · External reference
Bisphosphonate-induced osteopetrosis: Novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases
10.1359/jbmr.080511 · 2008 · External reference
Use of bisphosphonates in children-proceed with caution.
10.1038/nrendo.2009.58 · 2009 · External reference
Bisphosphonate associated osteonecrosis of the jaw
10.3899/jrheum.080759 · 2009 · External reference
Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American society for bone and mineral research
10.1359/jbmr.0707onj · 2007 · External reference
The effect of osteoporosis treatments on fatigue properties of cortical bone tissue
10.1016/j.bonr.2014.10.004 · 2015 · External reference
Zoledronate induces osteonecrosis of the jaw in sheep.
10.1016/j.jcms.2015.04.020 · 2015 · External reference
Aminobisphosphonate-treated ewes as a model of osteonecrosis of the jaw and of dental implant failure.
10.1002/jper.19-0213 · 2020 · External reference
Medication-related osteonecrosis of the jaw after long-term bisphosphonate treatment in a cat
10.1111/jvim.15409 · 2019 · External reference
Suspected bisphosphate-related osteonecrosis of the jaw in a cat being treated with alendronate for idiopathic hypercalcaemia
10.1136/vetreccr-2018-000798 · 2019 · External reference
Bilateral patellar fractures and increased cortical bone thickness associated with long-term oral alendronate treatment in a cat
2017 · External reference
Bisphosphonate related osteonecrosis of the jaw: A minipig large animal model
10.1016/j.bone.2012.04.020 · 2012 · External reference
The impact of circular exercise diameter on bone and joint health of juvenile animals
10.3390/ani12111379 · 2022 · External reference
Exercising sheep as a preclinical model for musculoskeletal research
10.2460/ajvr.23.09.0209 · 2023 · External reference
The effects of forced exercise on collagen type II fragments, lysyl oxidase concentrations, and total protein concentrations in sera and synovial fluid of lambs.
10.1016/j.jevs.2010.03.001 · 2010 · External reference
Unresolved reference
2014 · External reference
Clodronate disodium for treatment of clinical signs of navicular disease-a double-blinded placebo-controlled clinical trial.
10.21836/pem20170308 · 2017 · External reference
Pharmacokinetics and plasma protein binding of a single dose of clodronate disodium are similar for juvenile sheep and horses
10.2460/ajvr.23.03.0051 · 2023 · External reference
The arrive guidelines 2.0: Updated guidelines for reporting animal research
2020 · External reference
Endocrine and histologic correlates of the dynamics of the metacarpal growth plate in growing rams
10.2527/jas1989.67113124x · 1989 · External reference
Review of growth plate closure compared with age at sexual maturity and lifespan in laboratory animals
2002 · External reference
The inter- and intra-observer reliability of a locomotion scoring scale for sheep.
10.1016/j.tvjl.2007.12.028 · 2009 · External reference
Effects of graded exercise on bronchial blood flow and airway dimensions in sheep
10.1016/j.pupt.2006.03.003 · 2007 · External reference
Significant exercise-related changes in the serum levels of two biomarkers of collagen metabolism in young horses
10.1016/s1063-4584(03)00152-3 · 2003 · External reference
Response of serum biomechanical markers of bone metabolism to training in the juvenile racehorse
10.1016/s0737-0806(00)80116-1 · 2000 · External reference
Early effects of zoledronic acid and teriparatide on bone microarchitecture, remodeling and collagen crosslinks: Comparison between iliac crest and lumbar vertebra in ewes
10.1016/j.bone.2012.07.004 · 2012 · External reference
Analytical bone calcium and bone ash from mature laying hens correlates to bone mineral content calculated from quantitative computed tomography scans
10.3382/ps/pez165 · 2019 · External reference
Validation of the sheep as a large animal model for the study of vertebral osteoporosis.
10.1007/s00586-008-0813-8 · 2009 · External reference
Calves, as a model for juvenile horses, need only one sprint per week to experience increased bone strength
10.1093/jas/skz202 · 2019 · External reference
A threshold selection method from gray-level histograms
10.1109/tsmc.1979.4310076 · 1979 · External reference
A comparative study of automatic thresholding approaches for 3D x-ray microtomography of trabecular bone
10.1118/1.4817235 · 2013 · External reference
Effects of volume of interest (VOI) size on trabecular bone quantification in the juvenile distal femur.
10.1142/s0218957722500269 · 2023 · External reference
Micro-computed tomography assessment of bone structure in aging mice
10.1038/s41598-022-11965-4 · 2022 · External reference
Automated assessment of bone changes in cross-sectional micro-CT studies of murine experimental osteoarthritis
10.1371/journal.pone.0174294 · 2017 · External reference
Bone structure and composition in a hyperglycemic, obese, and leptin receptor-deficient rat: Microscale characterization of femur and calvarium
10.1016/j.bone.2023.116747 · 2023 · External reference
Altered topological blueprint of trabecular bone associates with skeletal pathology in humans
10.1016/j.bonr.2020.100264 · 2020 · External reference
Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis
10.1016/j.bone.2007.07.007 · 2007 · External reference
Bone turnover markers in sheep and goat: A review of the scientific literature
10.1590/0001-3765201720160407 · 2017 · External reference
Influence of high-altitude grazing on bone metabolism of growing sheep
2011 · External reference
Altitude, pasture type, and sheep breed affect bone metabolism and serum 25-hydroxyvitamin D in grazing lambs
10.1152/japplphysiol.01289.2012 · 2013 · External reference
Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model
10.1007/s00223-007-9091-4 · 2008 · External reference
Assessment of osteoclast number and function: Application in the development of new and improved treatment modalities for bone diseases
10.1007/s00198-006-0286-8 · 2007 · External reference
Effect of glucosamine on interleukin-1-conditioned articular cartilage
10.1111/j.2042-3306.2002.tb05422.x · 2002 · External reference
Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride
10.1016/0003-2697(87)90658-0 · 1987 · External reference
Bisphosphonates: effects on osteoblast
10.1007/s00228-012-1216-7 · 2012 · External reference
Tiludronate and clodronate do not affect bone structure or remodeling kinetics over a 60 day randomized trial
10.1186/s12917-018-1423-2 · 2018 · External reference
Clodronate improves lameness in horses without changing bone turnover markers
10.1111/evj.13011 · 2019 · External reference
Unresolved reference
2014 · External reference
Clodronate: New directions of use
2015 · External reference
Recent advances in understanding bisphosphonate effects on bone mechanical properties
10.1007/s11914-018-0430-3 · 2018 · External reference
Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone
10.1016/j.ejphar.2012.11.031 · 2013 · External reference
Determinants of structure–function relationships among bisphosphonates
10.1016/j.bone.2007.03.002 · 2007 · External reference
Bisphosphonates: Pharmacology and clinical approach to their use in equine osteoarticular diseases
10.1016/j.jevs.2014.01.009 · 2014 · External reference
Glomerular filtration rate and albumin excretion after maximal exercise in aging sedentary and active men
10.1093/gerona/61.11.1181 · 2006 · External reference
Exercise training augments regional bone and marrow blood flow during exercise
10.1249/mss.0000000000000342 · 2014 · External reference
Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats
1992 · External reference
Effect of dose, sex and age on the drug disposition of incadronate, a new bisphosphonate, in rat bone
10.1111/j.1600-0773.1996.tb00269.x · 1996 · External reference
10.1016/b978-0-12-813259-3.00003-8
10.1016/b978-0-12-813259-3.00003-8 · 2019 · External reference
Transforming growth factor-β controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression
10.1074/jbc.m303905200 · 2003 · External reference
Small changes in exercise, not nutrition, often result in measurable changes in bone
10.1017/s1478061508914493 · 2008 · External reference
Does weight‐bearing exercise affect non‐weight‐bearing bone?
10.1002/jbmr.5650080905 · 1993 · External reference
Normative data for iliac bone histomorphometry in growing children
10.1016/s8756-3282(99)00257-4 · 2000 · External reference
The effect of castration and age on the development of the Shetland sheep skeleton and a metric comparison between bones of males, females and castrates.
10.1006/jasc.1999.0452 · 2000 · External reference
Sexual dimorphism, activity budget and synchrony in groups of sheep
10.1007/s00442-005-0347-2 · 2006 · External reference
Bone mineral density and body composition in male children with hypogonadism
10.1007/bf03346513 · 2009 · External reference
Changes in bone metabolism in young castrated male rats
10.3349/ymj.2016.57.6.1386 · 2016 · External reference
Estrogens and androgens in skeletal physiology and pathophysiology
10.1152/physrev.00033.2015 · 2017 · External reference
Osteoporosis changes collagen/apatite orientation and Young’s modulus in vertebral cortical bone of rat
10.1007/s00223-018-0508-z · 2019 · External reference
Combination treatment with ibandronate and eldecalcitol prevents osteoporotic bone loss and deterioration of bone quality characterized by nano-arrangement of the collagen/apatite in an ovariectomized aged rat model
2022 · External reference
Making rats rise to erect bipedal stance for feeding partial prevented orchidectomy-induced bone loss and added bone to intact rats
10.1359/jbmr.2000.15.6.1158 · 2000 · External reference
Calcified Tissue Effect of running exercise on the bone loss induced by orchidectomy in the rat
10.1007/bf00310166 · 1994 · External reference
Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy
10.1007/s00198-003-1436-x · 2003 · External reference
Pharmacokinetics and pharmacodynamics of clodronate disodium evaluated in plasma, synovial fluid and urine
10.1111/evj.13244 · 2020 · External reference
Clodronate disodium is neither cytotoxic nor cytoprotective to normal and recombinant equine interleukin-1β-treated joint tissues in vitro.
2022 · External reference
Effect of bisphosphonates on viability, proliferation, and dexamethasone-induced apoptosis of articular chondrocytes
10.1136/ard.61.10.925 · 2002 · External reference
Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β
10.2460/ajvr.73.10.1530 · 2012 · External reference
Pharmacology of bisphosphonates in pain
10.1111/bph.14799 · 2021 · External reference
Intra-articular clodronate in patients with knee osteoarthritis non-responder to intra-articular hyaluronic acid—a case report series of 9 patients with 8-month follow-up.
2023 · External reference
Clodronate: A Vesicular ATP release blocker
10.1016/j.tips.2017.10.007 · 2018 · External reference
Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain
10.1073/pnas.1704847114 · 2017 · External reference
Renal safety of intravenous bisphosphonates in the treatment of osteoporosis.
2007 · External reference
