Research graph
References from The causal relationship between genetically predicted blood metabolites and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study. Local targets link to admitted publications; unresolved targets remain external evidence.
Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline.
10.1164/rccm.202202-0399st · 2022 · External reference
The Idiopathic Pulmonary Fibrosis Cell Atlas
10.1152/ajplung.00451.2020 · 2020 · External reference
Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses.
10.1038/s41598-021-81591-z · 2021 · External reference
The pathogenesis of pulmonary fibrosis: is there a fibrosis gene?
10.1016/s1357-2725(96)00141-0 · 1997 · External reference
The Interplay of the Genetic Architecture, Aging, and Environmental Factors in the Pathogenesis of Idiopathic Pulmonary Fibrosis
10.1165/rcmb.2020-0373ps · 2021 · External reference
Metabolomics: beyond biomarkers and towards mechanisms
10.1038/nrm.2016.25 · 2016 · External reference
Serum metabolic profiling identified a distinct metabolic signature in patients with idiopathic pulmonary fibrosis—a potential biomarker role for LysoPC.
10.1186/s12931-018-0714-2 · 2018 · External reference
Identification of the lipid biomarkers from plasma in idiopathic pulmonary fibrosis by Lipidomics.
10.1186/s12890-017-0513-4 · 2017 · External reference
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis
10.1164/rccm.201504-0780oc · 2015 · External reference
Metabolic Profiling Regarding Pathogenesis of Idiopathic Pulmonary Fibrosis
10.1021/acs.jproteome.6b00156 · 2016 · External reference
Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic study
10.1136/bmjresp-2017-000183 · 2017 · External reference
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids
10.1152/ajpcell.00586.2020 · 2021 · External reference
Changes in serum metabolomics in idiopathic pulmonary fibrosis and effect of approved antifibrotic medication.
10.3389/fphar.2022.837680 · 2022 · External reference
An atlas of genetic influences on human blood metabolites
10.1038/ng.2982 · 2014 · External reference
Mendelian randomization as an instrumental variable approach to causal inference.
10.1177/0962280206077743 · 2007 · External reference
Urticaria and increased risk of rheumatoid arthritis: a two-sample Mendelian randomisation study in European population.
10.1093/mr/roab052 · 2022 · External reference
Genetic association between circulating selenium level and the risk of schizophrenia in the European population: A two-sample Mendelian randomization study.
10.3389/fnut.2022.969887 · 2022 · External reference
Management of BMI Is a Potential New Approach for the Prevention of Idiopathic Pulmonary Fibrosis.
10.3389/fgene.2022.821029 · 2022 · External reference
Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study
10.1183/13993003.03979-2020 · 2022 · External reference
The causal relationship between gastro-oesophageal reflux disease and idiopathic pulmonary fibrosis: a bidirectional two-sample Mendelian randomisation study
10.1183/13993003.01585-2022 · 2023 · External reference
Mendelian randomisation highlights hypothyroidism as a causal determinant of idiopathic pulmonary fibrosis.
10.1016/j.ebiom.2021.103669 · 2021 · External reference
A Causal Atlas on Comorbidities in Idiopathic Pulmonary Fibrosis: A Bidirectional Mendelian Randomization Study.
10.1016/j.chest.2023.02.038 · 2023 · External reference
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
10.1016/j.xgen.2022.100192 · 2022 · External reference
Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis.
10.1136/thoraxjnl-2021-218577 · 2022 · External reference
Mendelian randomization studies: a review of the approaches used and the quality of reporting.
10.1093/ije/dyv071 · 2015 · External reference
Assessing the causal relationships between human blood metabolites and the risk of NAFLD: A comprehensive mendelian randomization study.
10.3389/fgene.2023.1108086 · 2023 · External reference
Association between circulating fatty acid metabolites and asthma risk: a two-sample bidirectional Mendelian randomization study.
10.1186/s12920-023-01545-4 · 2023 · External reference
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
10.1038/s41588-018-0099-7 · 2018 · External reference
Orienting the causal relationship between imprecisely measured traits using GWAS summary data.
10.1371/journal.pgen.1007081 · 2017 · External reference
PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations
10.1093/bioinformatics/btz469 · 2019 · External reference
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett’s oesophagus and provides insights into clinical heterogeneity in reflux diagnosis
10.1136/gutjnl-2020-323906 · 2022 · External reference
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study.
10.1017/s0033291719002678 · 2020 · External reference
Mediation Analysis: A Practitioner’s Guide.
10.1146/annurev-publhealth-032315-021402 · 2016 · External reference
Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study
10.1136/bmj.l1855 · 2019 · External reference
Dysregulation of metabolic pathways in pulmonary fibrosis
10.1016/j.pharmthera.2023.108436 · 2023 · External reference
Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling.
10.3389/fimmu.2020.587913 · 2020 · External reference
Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation
10.1165/rcmb.2020-0360oc · 2021 · External reference
Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways
10.1096/fj.201600428r · 2016 · External reference
Unresolved reference
2021 · External reference
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
10.1038/s41467-019-10839-0 · 2019 · External reference
Metformin ameliorates bleomycin-induced pulmonary fibrosis in mice by suppressing IGF-1.
2020 · External reference
Metformin attenuates TGF-β1-induced pulmonary fibrosis through inhibition of transglutaminase 2 and subsequent TGF-β pathways.
10.1007/s13205-020-02278-2 · 2020 · External reference
Unresolved reference
2018 · External reference
Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms
10.1016/j.biopha.2017.11.101 · 2018 · External reference
Metformin Does Not Affect Clinically Relevant Outcomes in Patients with Idiopathic Pulmonary Fibrosis.
10.1159/000489668 · 2018 · External reference
Evaluation for clinical benefit of metformin in patients with idiopathic pulmonary fibrosis and type 2 diabetes mellitus: a national claims-based cohort analysis
10.1186/s12931-022-02001-0 · 2022 · External reference
Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway.
10.3389/fphar.2021.661129 · 2021 · External reference
Induction of arginase I and II in bleomycin-induced fibrosis of mouse lung
10.1152/ajplung.00434.2002 · 2003 · External reference
Why caution should be applied when interpreting and promoting findings from Mendelian randomisation studies.
10.1136/gpsych-2023-101047 · 2023 · External reference
