Research graph
References from Development of a 99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model. Local targets link to admitted publications; unresolved targets remain external evidence.
Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines.
10.1016/j.biomaterials.2018.06.021 · 2018 · External reference
Pretargeted Immuno-PET of Pancreatic Cancer: Overcoming Circulating Antigen and Internalized Antibody to Reduce Radiation Doses.
10.2967/jnumed.115.163824 · 2016 · External reference
Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain.
10.1021/acschemneuro.0c00652 · 2020 · External reference
New insights into the pretargeting approach to image and treat tumours
10.1039/c5cs00784d · 2016 · External reference
Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging.
10.3390/ph15060685 · 2022 · External reference
Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry
10.1158/1535-7163.mct-16-0503 · 2017 · External reference
Pretargeted Imaging and Therapy
10.2967/jnumed.117.189944 · 2017 · External reference
Clearing and Masking Agents in Pretargeting Strategies.
10.3390/ph16040497 · 2023 · External reference
Pretargeted imaging using bioorthogonal chemistry in mice
10.1016/j.cbpa.2014.07.023 · 2014 · External reference
Antibodies against metal chelates
10.1038/316265a0 · 1985 · External reference
Pre-Targeted Immunoscintigraphy of Murine Tumors with Indium-111-Labeled Bifunctional Haptens.
1988 · External reference
Imaging of Tumor in Patients with Indium-111-Labeled Biotin and Streptavidin-Conjugated Antibodies: Preliminary Communication.
1990 · External reference
Tumor Pretargeting in Mice Using 99mTc-Labeled Morpholino, a DNA Analog
2002 · External reference
Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET.
10.1177/1536012118799838 · 2018 · External reference
Pretargeting with Cucurbituril–Adamantane Host–Guest Pair in Xenograft Models
2023 · External reference
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
10.1002/1521-3773(20010601)40:11<2004::aid-anie2004>3.0.co;2-5 · 2001 · External reference
From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions
10.1021/ar200148z · 2011 · External reference
Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity
10.1021/ja8053805 · 2008 · External reference
Inverse electron demand Diels–Alder reactions in chemical biology
10.1039/c7cs00184c · 2017 · External reference
Photochemical syntheses, transformations, and bioorthogonal chemistry of trans-cycloheptene and sila trans-cycloheptene Ag(i) complexes.
10.1039/c7sc04773h · 2018 · External reference
In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice
10.1002/anie.200906294 · 2010 · External reference
Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging
10.1039/d1sc02789a · 2021 · External reference
Development of the First Aliphatic 18F-Labeled Tetrazine Suitable for Pretargeted PET Imaging—Expanding the Bioorthogonal Tool Box
10.1021/acs.jmedchem.1c01326 · 2021 · External reference
Pretargeted imaging beyond the blood-brain barrier.
10.1039/d2md00360k · 2023 · External reference
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry.
10.2967/jnumed.112.115840 · 2013 · External reference
Unresolved reference
2021 · External reference
Design, synthesis, and imaging of small amphiphilic rhenium and 99mtechnetium tricarbonyl complexes.
10.1021/bc900022c · 2009 · External reference
Radiolabeling of fab and f’ab’)2 antibody fragments with 99mTc(I) tricarbonyl core using a new bifunctional tridentate ligand.
10.1097/mnm.0b013e328343dee5 · 2011 · External reference
One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co.
10.1039/c0dt01458c · 2011 · External reference
A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines
10.1021/acs.jmedchem.6b00938 · 2016 · External reference
A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives
10.1371/journal.pone.0167425 · 2016 · External reference
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry.
10.3791/55188-v · 2017 · External reference
Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging.
10.1016/j.bmcl.2019.02.014 · 2019 · External reference
Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging.
10.1186/s13550-019-0520-y · 2019 · External reference
Pretargeted PET of Osteodestructive Lesions in Dogs
10.1021/acs.molpharmaceut.2c00220 · 2022 · External reference
Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure
10.1172/jci115539 · 1991 · External reference
Pharmacokinetics of Alendronate.
10.2165/00003088-199936050-00002 · 1999 · External reference
Inverse electron demand Diels–Alder click chemistry for pretargeted PET imaging and radioimmunotherapy
10.1038/s41596-021-00540-2 · 2021 · External reference
Bioorthogonal Masking of Circulating Antibody-TCO Groups Using Tetrazine-Functionalized Dextran Polymers.
10.1021/acs.bioconjchem.8b00028 · 2018 · External reference
Diels–Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody.
10.2967/jnumed.113.123745 · 2013 · External reference
Exploring Structural Parameters for Pretargeting Radioligand Optimization
10.1021/acs.jmedchem.7b01108 · 2017 · External reference
Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry
10.1021/acsptsci.1c00007 · 2021 · External reference
Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma via the Modulation of Radioligand Pharmacokinetics
10.1021/acs.molpharmaceut.5b00294 · 2015 · External reference
A Pretargeted Imaging Strategy for EGFR-Positive Colorectal Carcinoma via Modulation of Tz-Radioligand Pharmacokinetics.
10.1007/s11307-020-01539-z · 2021 · External reference
Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo.
10.1002/chem.202201847 · 2022 · External reference
Metal-Catalyzed One-Pot Synthesis of Tetrazines Directly from Aliphatic Nitriles and Hydrazine
10.1002/anie.201201117 · 2012 · External reference
Development of a novel antibody–tetrazine conjugate for bioorthogonal pretargeting
10.1039/c6ob01411a · 2016 · External reference
Tetrazine-trans-cyclooctene ligation for the rapid construction of integrin αvβ3 targeted PET tracer based on a cyclic RGD peptide
10.1016/j.bmcl.2011.04.116 · 2011 · External reference
AMIDE: a free software tool for multimodality medical image analysis.
10.1162/153535003322556877 · 2003 · External reference
Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.
10.1021/bc200295y · 2011 · External reference
Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation
10.1039/c3cc41027g · 2013 · External reference
Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles.
10.1021/acsomega.6b00269 · 2017 · External reference
Development of 18F-Labeled Bispyridyl Tetrazines for In Vivo Pretargeted PET Imaging.
10.3390/ph15020245 · 2022 · External reference
Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging.
2020 · External reference
Evaluation of [64Cu]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In]In-DOTA-PEG11-BisPy-Tz.
2021 · External reference
DOTA-tetrazine probes with modified linkers for tumor pretargeting
10.1016/j.nucmedbio.2017.09.001 · 2017 · External reference
Metal-Free Cycloaddition Chemistry Driven Pretargeted Radioimmunotherapy Using α-Particle Radiation
10.1021/acs.bioconjchem.7b00612 · 2017 · External reference
Leveraging Bioorthogonal Click Chemistry to Improve 225Ac-Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma
10.1158/1078-0432.ccr-18-1650 · 2019 · External reference
Radiolabeling of a polypeptide polymer for intratumoral delivery of alpha-particle emitter, 225Ac, and beta-particle emitter, 177Lu.
10.1016/j.nucmedbio.2021.11.001 · 2022 · External reference
A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules: Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in Aqueous Solution and Its Reaction with a Bifunctional Ligand.
10.1021/ja980745t · 1998 · External reference
Influence of the Denticity of Ligand Systems on the in Vitro and in Vivo Behavior of 99mTc(I)−Tricarbonyl Complexes: A Hint for the Future Functionalization of Biomolecules.
10.1021/bc990127h · 2000 · External reference
Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation
10.1021/jacs.6b02168 · 2016 · External reference
Site-Specific Antibody Functionalization Using Tetrazine–Styrene Cycloaddition
10.1021/acs.bioconjchem.8b00114 · 2018 · External reference
On the consensus nomenclature rules for radiopharmaceutical chemist–y—Reconsideration of radiochemical conversion.
10.1016/j.nucmedbio.2020.11.003 · 2021 · External reference
Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals
1991 · External reference
