Research graph
References from Blocking IL-33 decelerates cartilage degeneration in knee osteoarthritis through mice model. Local targets link to admitted publications; unresolved targets remain external evidence.
Osteoarthritis
10.1016/s0140-6736(19)30417-9 · 2019 · External reference
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
10.1016/s0140-6736(18)32279-7 · 2018 · External reference
Risk factors and burden of osteoarthritis.
10.1016/j.rehab.2016.01.006 · 2016 · External reference
Epidemiology and burden of osteoarthritis
10.1093/bmb/lds038 · 2013 · External reference
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
10.1038/boneres.2016.44 · 2017 · External reference
Infrapatellar Fat Pad and Knee Osteoarthritis.
10.14336/ad.2019.1116 · 2020 · External reference
Subchondral bone remodelling in osteoarthritis
10.1302/2058-5241.4.180102 · 2019 · External reference
Contribution of Infrapatellar Fat Pad and Synovial Membrane to Knee Osteoarthritis Pain
10.1155/2019/6390182 · 2019 · External reference
Biologic basis of osteoarthritis: state of the evidence.
10.1097/bor.0000000000000162 · 2015 · External reference
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets
10.1002/1529-0131(200106)44:6<1237::aid-art214>3.0.co;2-f · 2001 · External reference
Macrophages in Tissue Repair, Regeneration, and Fibrosis
10.1016/j.immuni.2016.02.015 · 2016 · External reference
IL-33-activated murine mast cells control the dichotomy between RORγt(+) and Helios(+) T(regs) via the MK2/3-mediated IL-6 production in vitro.
10.1002/eji.201948154 · 2019 · External reference
Interleukin-33 and ST2 Signaling in Tumor Microenvironment
10.1089/jir.2018.0044 · 2019 · External reference
Biological strategies for osteoarthritis: from early diagnosis to treatment.
10.1007/s00264-020-04838-w · 2021 · External reference
Associations between serum IL-8 and knee symptoms, joint structures, and cartilage or bone biomarkers in patients with knee osteoarthritis
10.1007/s10067-019-04718-8 · 2019 · External reference
Interleukin-33 in health and disease
10.1038/nri.2016.95 · 2016 · External reference
The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention
10.1016/j.pharmthera.2021.107847 · 2021 · External reference
IL-33 and the intestine: The good, the bad, and the inflammatory
10.1016/j.cyto.2017.06.017 · 2017 · External reference
A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine
10.1016/j.cyto.2022.155891 · 2022 · External reference
The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review
10.1016/j.lfs.2019.116786 · 2019 · External reference
IL-33, IL-37, and Vitamin D Interaction Mediate Immunomodulation of Inflammation in Degenerating Cartilage.
2021 · External reference
Counteractive Effects of IL-33 and IL-37 on Inflammation in Osteoarthritis.
2022 · External reference
Double-stranded RNA released from damaged articular chondrocytes promotes cartilage degeneration via Toll-like receptor 3-interleukin-33 pathway.
10.1038/cddis.2017.534 · 2017 · External reference
Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis.
10.1093/rheumatology/keq188 · 2010 · External reference
Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis.
10.1038/nrrheum.2012.80 · 2012 · External reference
Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development
2020 · External reference
Subchondral bone microenvironment in osteoarthritis and pain
10.1038/s41413-021-00147-z · 2021 · External reference
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
10.1038/ncomms11385 · 2016 · External reference
The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse.
10.1016/j.joca.2007.03.006 · 2007 · External reference
Experimental osteoarthritis models in mice
10.1007/978-1-4939-1215-5_23 · 2014 · External reference
Interleukin-33—cytokine of dual function or novel alarmin?
10.1016/j.it.2009.03.003 · 2009 · External reference
The IL-33/ST2 pathway: therapeutic target and novel biomarker.
10.1038/nrd2660 · 2008 · External reference
The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases.
10.3389/fimmu.2017.00475 · 2017 · External reference
IL-33/ST2 as a potential target for tumor immunotherapy
10.1002/eji.202149175 · 2021 · External reference
Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family.
10.1111/imr.12619 · 2018 · External reference
Blockade of IL-33 signalling attenuates osteoarthritis
10.1002/cti2.1187 · 2020 · External reference
Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
10.1016/j.molmed.2013.05.002 · 2013 · External reference
Role of platelet-derived growth factors in physiology and medicine
10.1101/gad.1653708 · 2008 · External reference
Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation
10.1111/jcmm.16538 · 2021 · External reference
Alzheimer’s disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain
10.3233/jad-132081 · 2014 · External reference
MMP9 regulates the cellular response to inflammation after skeletal injury
10.1016/j.bone.2012.09.018 · 2013 · External reference
Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis.
10.2147/dddt.s209626 · 2019 · External reference
IL‑33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-κB pathway
10.3892/or.2017.5926 · 2017 · External reference
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade.
10.3109/10409238.2013.770819 · 2013 · External reference
Matrix metalloproteinases: role in arthritis
10.2741/1817 · 2006 · External reference
Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes
10.1002/1529-0131(200103)44:3<585::aid-anr107>3.0.co;2-c · 2001 · External reference
