Research graph
References from SNP-SNP positive interaction between MMP2 and MMP12 increases the risk of COPD. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2022 · External reference
Unresolved reference
2006 · External reference
Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment
10.1016/s2213-2600(21)00506-3 · 2022 · External reference
The Cumulative Effect of Gene-Gene Interactions Between GSTM1, CHRNA3, CHRNA5 and SOD3 Gene Polymorphisms Combined with Smoking on COPD Risk.
10.2147/copd.s320841 · 2021 · External reference
Effect of Smoking on Metalloproteinases (MMPs) Activity in Patients with Acute Myocardial Infarction (AMI).
2014 · External reference
MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFR/Akt/GSK3β/β-catenin pathway: Amelioration by fisetin
10.1016/j.cbi.2019.108846 · 2019 · External reference
The influence of smoking on the levels of matrix metalloproteinase-8 and periodontal parameters in smoker and nonsmoker patients with chronic periodontitis: A clinicobiochemical study.
10.1016/j.jobcr.2015.08.004 · 2016 · External reference
Mmp12 Is Upregulated by in utero Second-Hand Smoke Exposures and Is a Key Factor Contributing to Aggravated Lung Responses in Adult Emphysema, Asthma, and Lung Cancer Mouse Models
10.3389/fphys.2021.704401 · 2021 · External reference
Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD.
10.1186/1465-9921-8-81 · 2007 · External reference
Evaluation of matrix metalloproteinase-9 and tissue inhibitor metalloproteinase-1 levels in bronchoalveolar lavage of apparently healthy smokers.
10.1016/j.ejcdt.2014.12.001 · 2015 · External reference
Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease.
10.3390/ijms24043786 · 2023 · External reference
MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells.
10.3390/ijms20123107 · 2019 · External reference
Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity.
10.2147/copd.s103281 · 2016 · External reference
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD.
10.1186/s12890-020-01323-3 · 2020 · External reference
Serum metalloproteinase-9 is related to COPD severity and symptoms—cross-sectional data from a population based cohort-study.
10.1186/s12931-015-0188-4 · 2015 · External reference
Mechanisms of cigarette smoke-induced COPD: insights from animal models.
2008 · External reference
Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells
10.1016/s0008-6363(01)00220-6 · 2001 · External reference
MMP2 and MMP10 Polymorphisms Are Related to Steroid-Induced Osteonecrosis of the Femoral Head among Chinese Han Population
10.1155/2019/8298193 · 2019 · External reference
An Overview of Matrix Metalloproteinase 9 Polymorphism and Gastric Cancer Risk.
10.7314/apjcp.2015.16.17.7393 · 2015 · External reference
rs3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder cancer
10.14715/cmb/2017.63.9.9 · 2017 · External reference
Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD.
10.1136/thx.2011.159087 · 2011 · External reference
MMP2 Polymorphism Affects Plasma Matrix Metalloproteinase (MMP)-2 Levels, and Correlates with the Decline in Lung Function in Hypersensitivity Pneumonitis Positive to Autoantibodies Patients.
10.3390/biom9100574 · 2019 · External reference
The 1G/1G+1G/2G Genotypes of MMP1 rs1799750 Are Associated with Higher Levels of MMP-1 and Are Both Associated with Lipodystrophy in People Living with HIV on Antiretroviral Therapy
10.1089/aid.2020.0237 · 2021 · External reference
Gene–Gene Interactions Between Glutathione S-Transferase M1 and Matrix Metalloproteinases 1, 9, and 12 in Chronic Obstructive Pulmonary Disease in Serbians.
10.1080/15412555.2017.1369022 · 2017 · External reference
Genetic polymorphisms of matrix metalloproteinases and protein levels in chronic obstructive pulmonary disease in a Mexican population
10.2217/bmm.15.75 · 2015 · External reference
GOLD COPD report: 2023 update
10.1016/s2213-2600(22)00494-5 · 2023 · External reference
The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.
10.1111/j.1360-0443.1991.tb01879.x · 1991 · External reference
Allele-specific detection of C-1562T polymorphism in the matrix metalloproteinase-9 gene: Genotyping by MADGE
10.1016/j.clinbiochem.2006.01.005 · 2006 · External reference
Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer.
10.1371/journal.pone.0184448 · 2017 · External reference
Matrix Metalloproteinase-2 Polymorphisms in Chronic Heart Failure: Relationship with Susceptibility and Long-Term Survival.
10.1371/journal.pone.0161666 · 2016 · External reference
Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the risk of ischemic stroke in a Tunisian population
10.1016/j.jns.2014.04.036 · 2014 · External reference
Genetic model selection for a case-control study and a meta-analysis
10.1016/j.mgene.2015.04.003 · 2015 · External reference
Estimating interaction on an additive scale between continuous determinants in a logistic regression model.
10.1093/ije/dym157 · 2007 · External reference
Proteinase-activated receptor-1 regulation of macrophage elastase (MMP-12) secretion by serine proteinases.
10.1074/jbc.m005788200 · 2000 · External reference
Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages
10.1165/rcmb.2006-0345oc · 2007 · External reference
Unresolved reference
2011 · External reference
Matrix metalloproteinases in emphysema
10.1016/j.matbio.2018.01.018 · 2018 · External reference
Biochemical and Biological Attributes of Matrix Metalloproteinases.
10.1016/bs.pmbts.2017.02.005 · 2017 · External reference
Does Protease–Antiprotease Imbalance Explain Chronic Obstructive Pulmonary Disease?
2016 · External reference
Matrix metalloproteinases in destructive lung disease
10.1016/j.matbio.2015.02.002 · 2015 · External reference
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
10.1126/science.277.5334.2002 · 1997 · External reference
Analysis of the inflammatory response induced by rhMMP-12 catalytic domain instilled in mouse airways
10.1016/j.intimp.2004.10.011 · 2005 · External reference
Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release
10.1164/rccm.200212-1396oc · 2003 · External reference
Lymphoid tissue and emphysema in the lungs of transgenic mice inducibly expressing tumor necrosis factor-alpha
10.1165/rcmb.2003-0062oc · 2004 · External reference
Matrix metalloproteinases in COPD.
2012 · External reference
[Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China].
2005 · External reference
The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
10.1093/hmg/11.5.569 · 2002 · External reference
Relationships of COX2 and MMP12 genetic polymorphisms with chronic obstructive pulmonary disease risk: a meta-analysis
10.1007/s11033-014-3715-3 · 2014 · External reference
Association of MMP—12 polymorphisms with severe and very severe COPD: A case control study of MMPs—1, 9 and 12in a European population
10.1186/1471-2350-11-7 · 2010 · External reference
A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) is associated with coronary triple-vessel disease.
10.1016/j.matbio.2003.10.004 · 2004 · External reference
Ghrelin Alleviates Intestinal Dysfunction in Sepsis Through the KLF4/MMP2 Regulatory Axis by Activating SIRT1.
10.3389/fimmu.2021.646775 · 2021 · External reference
Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells
10.1155/2014/521754 · 2014 · External reference
Knockdown of Linc00511 inhibits TGF-β-induced cell migration and invasion by suppressing epithelial-mesenchymal transition and down-regulating MMPs expression
10.1016/j.biopha.2019.109049 · 2020 · External reference
