Research graph
References from An orchestra of machine learning methods reveals landmarks in single-cell data exemplified with aging fibroblasts. Local targets link to admitted publications; unresolved targets remain external evidence.
UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction.
2018 · External reference
Visualizing Data using t-SNE
2008 · External reference
Optimized cell type signatures revealed from single-cell data by combining principal feature analysis, mutual information, and machine learning.
10.1016/j.csbj.2023.06.002 · 2023 · External reference
A Unified Approach to Interpreting Model Predictions.
2017 · External reference
Why should I trust you?" Explaining the predictions of any classifier
2016 · External reference
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
10.1038/s42003-020-0922-4 · 2020 · External reference
Longevity leap: mind the healthspan gap.
10.1038/s41536-021-00169-5 · 2021 · External reference
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments.
10.1038/s41392-022-01251-0 · 2022 · External reference
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
10.1016/j.cell.2018.10.012 · 2018 · External reference
SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin
10.1016/j.jid.2017.09.045 · 2018 · External reference
Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations
10.1016/j.jid.2018.01.016 · 2018 · External reference
The hallmarks of fibroblast ageing
10.1016/j.mad.2014.03.004 · 2014 · External reference
Natural and Sun-Induced Aging of Human Skin.
10.1101/cshperspect.a015370 · 2015 · External reference
A principal feature analysis
10.1016/j.jocs.2021.101502 · 2022 · External reference
MARS: discovering novel cell types across heterogeneous single-cell experiments
10.1038/s41592-020-00979-3 · 2020 · External reference
On lines and planes of closest fit to systems of points in space.
10.1080/14786440109462720 · 1901 · External reference
Unresolved reference
1996 · External reference
10.21105/joss.00205 · 2017 · Admitted local publication
The Chi-square test of independence.
10.11613/bm.2013.018 · 2013 · External reference
Robust correlation estimation and UMAP assisted topological analysis of omics data for disease subtyping
10.1016/j.compbiomed.2023.106640 · 2023 · External reference
Unresolved reference
2021 · External reference
Unresolved reference
2020 · External reference
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
10.1089/omi.2011.0118 · 2012 · External reference
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
The Molecular Signatures Database Hallmark Gene Set Collection.
10.1016/j.cels.2015.12.004 · 2015 · External reference
The Hallmarks of Aging.
10.1016/j.cell.2013.05.039 · 2013 · External reference
Hallmarks of aging: An expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
A survey on feature selection approaches for clustering
10.1007/s10462-019-09800-w · 2020 · External reference
Unsupervised Adaptive Feature Selection with Binary Hashing
2023 · External reference
Unsupervised Feature Selection With Flexible Optimal Graph
2022 · External reference
Two-Dimensional Unsupervised Feature Selection via Sparse Feature Filter
2022 · External reference
Unsupervised feature selection via adaptive autoencoder with redundancy control.
10.1016/j.neunet.2022.03.004 · 2022 · External reference
Phosphorylation of PLK3 Is Controlled by Protein Phosphatase 6.
10.3390/cells9061506 · 2020 · External reference
Unmasking Transcriptional Heterogeneity in Senescent Cells
10.1016/j.cub.2017.07.033 · 2017 · External reference
Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging
10.3390/ijms23116135 · 2022 · External reference
Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults.
10.3389/fragi.2020.602108 · 2020 · External reference
Geroscience: Linking Aging to Chronic Disease
10.1016/j.cell.2014.10.039 · 2014 · External reference
Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma.
10.18632/aging.203940 · 2022 · External reference
The role of Plk3 in oncogenesis
10.1038/onc.2015.105 · 2016 · External reference
Stimulation of Polo-Like Kinase 3 mRNA Decay by Tristetraprolin
10.1128/mcb.00982-08 · 2009 · External reference
Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response.
10.1155/2022/4201287 · 2022 · External reference
Cell Cycle Arrest and Apoptosis Induced by Human Polo-Like Kinase 3 Is Mediated through Perturbation of Microtubule Integrity
10.1128/mcb.22.10.3450-3459.2002 · 2002 · External reference
CCDC88A Post-Transcriptionally Regulates VEGF via miR-101 and Subsequently Regulates Hepatocellular Carcinoma.
2022 · External reference
SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging.
10.1016/j.omtn.2021.01.023 · 2021 · External reference
STAT3 Protein Up-regulates Gα-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis *.
10.1074/jbc.m112.390781 · 2012 · External reference
STAT3 promotes a youthful epigenetic state in articular chondrocytes
10.1111/acel.13773 · 2023 · External reference
Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes.
10.3390/antiox10020334 · 2021 · External reference
Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication
2022 · External reference
Sirtuin activators and inhibitors: Promises, achievements, and challenges
10.1016/j.pharmthera.2018.03.004 · 2018 · External reference
Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells
10.1111/cas.14637 · 2020 · External reference
Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells
10.1111/jnc.12831 · 2014 · External reference
RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP–negative Glioblastoma
10.1158/1078-0432.ccr-20-2141 · 2021 · External reference
C2H2 Zinc Finger Proteins: The Largest but Poorly Explored Family of Higher Eukaryotic Transcription Factors.
2017 · External reference
Identification of Zinc Finger Genes that are Differentially Expressed upon Apoptosis of Ramos B Cells
1998 · External reference
Specific Interactions of the Autoantigen L7 with Multi-zinc Finger Protein ZNF7 and Ribosomal Protein S7 *
10.1074/jbc.272.35.22243 · 1997 · External reference
A critical role for miR‑135a‑5p‑mediated regulation of SLC24A2 in neuropathic pain
10.3892/mmr.2020.11262 · 2020 · External reference
Unresolved reference
2021 · External reference
Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease.
2018 · External reference
A Genome-Wide Scan on Individual Typology Angle Found Variants at SLC24A2 Associated with Skin Color Variation in Chinese Populations
10.1016/j.jid.2021.07.186 · 2022 · External reference
Dysregulated Circulating Apoptosis- and Autophagy-Related lncRNAs as Diagnostic Markers in Coronary Artery Disease.
10.1155/2021/5517786 · 2021 · External reference
Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics
10.2147/copd.s354634 · 2022 · External reference
FOXA1 mediates p16INK4a activation during cellular senescence
10.1038/emboj.2013.35 · 2013 · External reference
Links of Cytoskeletal Integrity with Disease and Aging
2022 · External reference
Insulin and brain aging
2017 · External reference
Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer’s disease
10.1016/j.neurobiolaging.2023.01.010 · 2023 · External reference
Vascular endothelial growth factor improves the cognitive decline of Alzheimer’s disease via concurrently inducing the expression of ADAM10 and reducing the expression of β-site APP cleaving enzyme 1 in Tg2576 mice
10.1016/j.neures.2018.04.003 · 2019 · External reference
Progeria and Aging—Omics Based Comparative Analysis.
10.3390/biomedicines10102440 · 2022 · External reference
Metadata integrity in bioinformatics: Bridging the gap between data and knowledge
10.1016/j.csbj.2023.10.006 · 2023 · External reference
