Research graph
References from Vitamin D regulates COVID-19 associated severity by suppressing the NLRP3 inflammasome pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China.
10.1001/jamainternmed.2020.0994 · 2020 · External reference
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients
10.1084/jem.20201707 · 2021 · External reference
NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity
10.1016/j.micinf.2021.104913 · 2022 · External reference
Association between development of severe COVID-19 and a polymorphism in the CIAS1 gene that codes for an inflammasome component.
10.1038/s41598-023-38095-9 · 2023 · External reference
Pulmonary vascular inflammation with fatal coronavirus disease 2019 (COVID-19): possible role for the NLRP3 inflammasome.
10.1186/s12931-022-01944-8 · 2022 · External reference
Inflammasome activation in neutrophils of patients with severe COVID-19
10.1182/bloodadvances.2021005949 · 2022 · External reference
Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severity
10.1182/bloodadvances.2020003918 · 2021 · External reference
Inflammasomes: mechanism of assembly, regulation and signalling
10.1038/nri.2016.58 · 2016 · External reference
Spontaneous NLRP3 inflammasome-driven IL-1-beta secretion is induced in severe COVID-19 patients and responds to anakinra treatment
10.1016/j.jaci.2022.05.029 · 2022 · External reference
Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients
10.1007/s00011-023-01718-y · 2023 · External reference
Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic Molecules.
10.3390/biomedicines9121823 · 2021 · External reference
Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects
10.1007/s40519-016-0312-6 · 2017 · External reference
Editorial—Vitamin D status: a key modulator of innate immunity and natural defense from acute viral respiratory infections
2020 · External reference
An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men
10.1093/ajcn/86.3.714 · 2007 · External reference
Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey
10.1001/archinternmed.2008.560 · 2009 · External reference
Is the vitamin D status of patients with COVID-19 associated with reduced mortality? A systematic review and meta-analysis.
2023 · External reference
Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study
2022 · External reference
Vitamin D Status Is Associated With In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients
10.1016/j.mayocp.2021.01.001 · 2021 · External reference
Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1.
10.3390/nu13114047 · 2021 · External reference
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
10.3390/ph16010130 · 2023 · External reference
The role of vitamin D as a potential adjuvant for COVID-19 vaccines.
2021 · External reference
Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study
10.3390/nu12113377 · 2020 · External reference
Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study
10.1016/j.jsbmb.2020.105751 · 2020 · External reference
1,25(OH)(2) D(3) alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation
10.1002/jlb.3ma0320-406rr · 2020 · External reference
1,25-Dihydroxy Vitamin D(3) Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM(2.5)via the p38/NF-kappaB/NLRP3 Pathway
10.1007/s10753-018-0928-y · 2019 · External reference
Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis
10.3389/fphar.2020.00200 · 2020 · External reference
Vitamin D(3) Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS/TXNIP/NLRP3 Inflammasome Pathway
2018 · External reference
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination
10.3389/fimmu.2019.02783 · 2019 · External reference
Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.
10.1016/j.redox.2018.101093 · 2019 · External reference
Vitamin D3 attenuates SARS-CoV-2 nucleocapsid protein-caused hyperinflammation by inactivating the NLRP3 inflammasome through the VDR-BRCC3 signaling pathway in vitro and in vivo
10.1002/mco2.318 · 2020 · External reference
In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age
10.1371/journal.pbio.3000849 · 2020 · External reference
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
10.1186/s13073-020-00823-5 · 2021 · External reference
Large-Scale Multi-omic Analysis of COVID-19
10.1016/j.cels.2020.10.003 · 2021 · External reference
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
10.1038/s41591-020-0901-9 · 2020 · External reference
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19.
2020 · External reference
Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cells.
10.3389/fimmu.2022.999233 · 2022 · External reference
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts.
10.1161/circresaha.121.319060 · 2021 · External reference
An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages
10.7150/thno.66831 · 2022 · External reference
Unresolved reference
2020 · External reference
Unresolved reference
2024 · External reference
Unresolved reference
External reference
SARS-CoV-2 Infection-Induced Promoter Hypomethylation as an Epigenetic Modulator of Heat Shock Protein A1L (HSPA1L) Gene.
10.3389/fgene.2021.622271 · 2021 · External reference
SARS-CoV-2 Switches ’on’ MAPK and NFkappaB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression.
10.3389/fphar.2021.631879 · 2021 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Vitamin D enhances type I IFN signaling in COVID-19 patients.
10.1038/s41598-022-22307-9 · 2022 · External reference
Lung Inflammasome Activation in SARS-CoV-2 Post-Mortem Biopsies.
10.3390/ijms232113033 · 2022 · External reference
Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study.
10.1177/01410768231154703 · 2023 · External reference
Spotlight on the NLRP3 inflammasome pathway
10.2147/jir.s141220 · 2018 · External reference
Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1beta response and host resistance to Trypanosoma cruzi infection
10.4049/jimmunol.1203293 · 2013 · External reference
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
10.1016/s1097-2765(02)00599-3 · 2002 · External reference
The CARD plays a critical role in ASC foci formation and inflammasome signalling
10.1042/bj20121198 · 2013 · External reference
The inflammasomes
10.1016/j.cell.2010.01.040 · 2010 · External reference
Inflammasomes: too big to miss
10.1172/jci40599 · 2009 · External reference
Innate instruction of adaptive immunity revisited: the inflammasome
10.1002/emmm.200900014 · 2009 · External reference
Critical functions of priming and lysosomal damage for NLRP3 activation
10.1002/eji.200940185 · 2010 · External reference
COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
10.1155/2021/8874339 · 2021 · External reference
Luteolin-rich fraction from Perilla frutescens seed meal inhibits spike glycoprotein S1 of SARS-CoV-2-induced NLRP3 inflammasome lung cell inflammation via regulation of JAK1/STAT3 pathway: A potential anti-inflammatory compound against inflammation-induced long-COVID.
10.3389/fmed.2022.1072056 · 2022 · External reference
The Many Faces of JAKs and STATs Within the COVID-19 Storm.
10.3389/fimmu.2021.690477 · 2021 · External reference
JAK Inhibition as a New Treatment Strategy for Patients with COVID-19
10.1159/000508247 · 2020 · External reference
COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis
10.3346/jkms.2020.35.e343 · 2020 · External reference
Viral dependence on cellular ion channels—an emerging anti-viral target?
10.1099/jgv.0.000712 · 2017 · External reference
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
10.1016/j.immuni.2021.05.004 · 2021 · External reference
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
10.1038/s41586-018-0372-z · 2018 · External reference
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation.
10.1038/s41467-021-25015-6 · 2021 · External reference
Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
10.1096/fj.201802418r · 2019 · External reference
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death
10.1038/s41419-018-0917-y · 2018 · External reference
Activation of NF-kappaB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2.
10.1038/s41598-021-92941-2 · 2021 · External reference
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison
10.1038/s41590-020-00840-x · 2021 · External reference
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
10.1126/science.abc6027 · 2020 · External reference
Unresolved reference
2021 · External reference
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling.
10.1038/s41392-020-00438-7 · 2020 · External reference
Inflammasome Activation Dampens Type I IFN Signaling to Strengthen Anti-Toxoplasma Immunity.
10.1128/mbio.02361-22 · 2022 · External reference
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial
10.1001/jama.2020.26848 · 2021 · External reference
High-dose vitamin D versus placebo to prevent complications in COVID-19 patients: Multicentre randomized controlled clinical trial.
10.1371/journal.pone.0267918 · 2022 · External reference
High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial.
10.1371/journal.pmed.1003999 · 2022 · External reference
A randomized pilot study using calcitriol in hospitalized COVID-19 patients
10.1016/j.bone.2021.116175 · 2022 · External reference
