Research graph
References from Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics. Local targets link to admitted publications; unresolved targets remain external evidence.
Living with Chronic Kidney Disease and Type 2 Diabetes Mellitus: The Patient and Clinician Perspective
10.1007/s12325-022-02325-9 · 2023 · External reference
Obesity as a multisystem disease: Trends in obesity rates and obesity-related complications
10.1111/dom.14290 · 2021 · External reference
Nonalcoholic steatohepatitis and increased risk of chronic kidney disease
10.1016/j.metabol.2010.07.022 · 2011 · External reference
Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis
10.1371/journal.pmed.1001680 · 2014 · External reference
Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
10.4103/ijem.ijem_585_17 · 2018 · External reference
Clinical implications and guidelines for CKD in type 2 diabetes
10.1093/ndt/gfac285 · 2023 · External reference
Obesity and liver disease
10.1053/beem.2002.0225 · 2002 · External reference
Obesity and chronic kidney disease
10.1053/j.jrn.2010.05.008 · 2010 · External reference
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
10.3748/wjg.v20.i42.15539 · 2014 · External reference
Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease—novel insights into cellular communication circuits
10.1016/j.jhep.2022.06.012 · 2022 · External reference
Acute kidney injury
10.1038/s41572-021-00284-z · 2021 · External reference
Acute Kidney Injury to Chronic Kidney Disease Transition
10.1159/000484962 · 2018 · External reference
Deciphering cell-cell interactions and communication from gene expression
10.1038/s41576-020-00292-x · 2021 · External reference
Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data
10.1038/s41467-022-30755-0 · 2022 · External reference
A Comparison of Cell-Cell Interaction Prediction Tools Based on scRNA-seq Data
2023 · External reference
CITEdb: a manually curated database of cell-cell interactions in human
10.1093/bioinformatics/btac654 · 2022 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Museum of spatial transcriptomics
10.1038/s41592-022-01409-2 · 2022 · External reference
Method of the Year: spatially resolved transcriptomics
10.1038/s41592-020-01033-y · 2021 · External reference
The dawn of spatial omics
10.1126/science.abq4964 · 2023 · External reference
Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution
10.1038/s41592-022-01480-9 · 2022 · External reference
Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s Disease
2023 · External reference
Single-cell RNA-seq with spatial transcriptomics to create an atlas of human diabetic kidney disease
10.1096/fj.202202013rr · 2023 · External reference
Single-cell and spatial transcriptomics reveal the fibrosis-related immune landscape of biliary atresia
10.1002/ctm2.1070 · 2022 · External reference
Spatial and single-cell transcriptomics reveal the regional division of the spatial structure of NASH fibrosis
2023 · External reference
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics
10.1038/s41576-021-00370-8 · 2021 · External reference
Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomics
2020 · External reference
An atlas of healthy and injured cell states and niches in the human kidney
10.1038/s41586-023-05769-3 · 2023 · External reference
A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease
10.1038/s41467-023-38975-8 · 2023 · External reference
An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis
10.1126/scitranslmed.add3949 · 2023 · External reference
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
10.1002/hep.20701 · 2005 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data
10.1093/database/baz046 · 2019 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Cell2location maps fine-grained cell types in spatial transcriptomics
10.1038/s41587-021-01139-4 · 2022 · External reference
Identifying Spatial Co-occurrence in Healthy and InflAmed tissues (ISCHIA)
2023 · External reference
Evaluation of critical data processing steps for reliable prediction of gene co-expression from large collections of RNA-seq data
10.1371/journal.pone.0263344 · 2022 · External reference
Review on Inflammation Markers in Chronic Kidney Disease
10.3390/biomedicines9020182 · 2021 · External reference
Organ crosstalk: the potent roles of inflammation and fibrotic changes in the course of organ interactions
10.1007/s00011-019-01271-7 · 2019 · External reference
Pathology and natural history of organ fibrosis
10.1016/j.coph.2019.09.009 · 2019 · External reference
Gene Expression Predicts Histological Severity and Reveals Distinct Molecular Profiles of Nonalcoholic Fatty Liver Disease
10.1038/s41598-019-48746-5 · 2019 · External reference
The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction
10.1152/ajprenal.00164.2016 · 2016 · External reference
Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD
10.1038/nrneph.2015.3 · 2015 · External reference
Epidermal growth factor receptor signaling in the kidney: key roles in physiology and disease
10.1161/hypertensionaha.108.113860 · 2008 · External reference
Role of epidermal growth factor receptor in acute and chronic kidney injury
10.1038/ki.2012.435 · 2013 · External reference
Epidermal Growth Factor Receptor: A Potential Therapeutic Target for Diabetic Kidney Disease
10.3389/fphar.2020.598910 · 2020 · External reference
Potential Roles of Long Noncoding RNAs as Therapeutic Targets in Renal Fibrosis
2020 · External reference
TGF-beta Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis
10.1016/j.ymthe.2017.09.024 · 2018 · External reference
Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b
10.2337/db17-0816 · 2018 · External reference
TGF-beta/Smad Signaling Pathway in Tubulointerstitial Fibrosis
10.3389/fphar.2022.860588 · 2022 · External reference
Angiotensin II mediates hypertensive cardiac fibrosis via an Erbb4-IR-dependent mechanism
10.1016/j.omtn.2023.06.017 · 2023 · External reference
Smad3 Signatures in Renal Inflammation and Fibrosis
10.7150/ijbs.71595 · 2022 · External reference
GWAS in people of Middle Eastern descent reveals a locus protective of kidney function-a cross-sectional study
10.1186/s12916-022-02267-7 · 2022 · External reference
Osteopontin as a Biomarker in Chronic Kidney Disease
10.3390/biomedicines11051356 · 2023 · External reference
The role of osteopontin in kidney diseases
10.1007/s00011-018-1200-5 · 2019 · External reference
Expression, roles, receptors, and regulation of osteopontin in the kidney
10.1046/j.1523-1755.2001.00032.x · 2001 · External reference
Osteopontin in Cardiovascular Diseases
10.3390/biom11071047 · 2021 · External reference
Prognostic value of fibrosis-related markers in dilated cardiomyopathy: A link between osteopontin and cardiovascular events
10.1016/j.advms.2017.10.004 · 2018 · External reference
Progression of diabetic nephropathy enhances the plasma osteopontin level in type 2 diabetic patients
10.1507/endocrj.51.499 · 2004 · External reference
Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by alphaV Integrins
10.1159/000499506 · 2019 · External reference
Melatonin Suppresses Renal Cortical Fibrosis by Inhibiting Cytoskeleton Reorganization and Mitochondrial Dysfunction through Regulation of miR-4516
2020 · External reference
Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis
10.1016/j.celrep.2023.112550 · 2023 · External reference
Liver immunology
10.1002/cphy.c120011 · 2013 · External reference
Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology
2014 · External reference
BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration
10.3390/ijms19010039 · 2017 · External reference
Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease
10.1136/gutjnl-2014-306968 · 2015 · External reference
TAM Receptors in the Pathophysiology of Liver Disease
10.3390/livers2010002 · 2022 · External reference
AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells
10.1016/j.jcmgh.2023.03.007 · 2023 · External reference
Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation
10.1016/j.jhep.2015.04.013 · 2015 · External reference
A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target
10.1016/j.jcmgh.2019.10.010 · 2020 · External reference
Gas6 in chronic liver disease-a novel blood-based biomarker for liver fibrosis
10.1038/s41420-023-01551-6 · 2023 · External reference
Recent Insight into the Role of Fibrosis in Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma
10.3390/ijms20071745 · 2019 · External reference
Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma
10.1073/pnas.0409722102 · 2005 · External reference
Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis
10.1016/j.ajpath.2012.09.006 · 2013 · External reference
Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice
10.1111/cas.12730 · 2015 · External reference
Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis
10.1111/j.1432-0436.2007.00235.x · 2007 · External reference
Role of Smad3 in platelet-derived growth factor-C-induced liver fibrosis
10.1152/ajpcell.00423.2014 · 2016 · External reference
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo
10.1038/s41598-017-17285-2 · 2017 · External reference
Liver Fibrosis in Non-alcoholic Fatty Liver Disease: From Liver Biopsy to Non-invasive Biomarkers in Diagnosis and Treatment
10.3389/fmed.2021.615978 · 2021 · External reference
Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma
10.1002/ijc.28421 · 2014 · External reference
Predictive significance of glomerular insulin receptor substrate-1 in patients with diabetic kidney disease
10.1016/j.metop.2023.100240 · 2023 · External reference
Insulin receptors in the kidneys in health and disease
10.5527/wjn.v8.i1.11 · 2019 · External reference
Hepatic insulin receptor: new views on the mechanisms of liver disease
10.1016/j.metabol.2023.155607 · 2023 · External reference
Visfatin: the missing link between intra-abdominal obesity and diabetes?
10.1016/j.molmed.2005.06.010 · 2005 · External reference
Visfatin: structure, function and relation to diabetes mellitus and other dysfunctions
10.2174/092986708785133004 · 2008 · External reference
Role of visfatin in obesity-induced insulin resistance
10.12998/wjcc.v10.i30.10840 · 2022 · External reference
Visfatin Induces Inflammation and Insulin Resistance via the NF-kappaB and STAT3 Signaling Pathways in Hepatocytes
2019 · External reference
Serum Visfatin Levels in Nonalcoholic Fatty Liver Disease and Liver Fibrosis: Systematic Review and Meta-Analysis
10.3390/jcm10143029 · 2021 · External reference
Correlation of visfatin level with non-alcoholic fatty liver in metabolic syndrome
2017 · External reference
