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References from 3,3’-((3,4,5-trifluoropHenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) inhibit lung cancer cell proliferation and migration. Local targets link to admitted publications; unresolved targets remain external evidence.
Recent advancements of coumarin-based anticancer agents: An up-to-date review
10.1016/j.bioorg.2020.104163 · 2020 · External reference
Biscoumarin-1,2,3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro alpha-glucosidase inhibition, kinetic, and docking studies
10.1016/j.bioorg.2019.103206 · 2019 · External reference
Antitumor activities of biscoumarin and dihydropyran derivatives
10.1016/j.bmcl.2016.07.023 · 2016 · External reference
A synthetic biscoumarin suppresses lung cancer cell proliferation and induces cell apoptosis by increasing expression of RIP1
10.4103/cjp.cjp_107_21 · 2022 · External reference
The Fluorine Effect in Zwitterionic Half-Sandwich Iridium(III) Anticancer Complexes
2019 · External reference
Synthesis, characterization, and anti-cancer activity of new chalcone derivatives containing naphthalene and fluorine moieties
2020 · External reference
Design, synthesis, and evaluation of fluorine and Naphthyridine–Based half-sandwich organoiridium/ruthenium complexes with bioimaging and anticancer activity
2019 · External reference
Anticancer SAR Establishment and Novel Accruing Signal Transduction Model of Drug Action Using Biscoumarin Scaffold
2019 · External reference
Matrix metalloproteinases: regulators of the tumor microenvironment
10.1016/j.cell.2010.03.015 · 2010 · External reference
KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway
10.3389/fgene.2022.848926 · 2022 · External reference
Signal integration by JNK and p38 MAPK pathways in cancer development
10.1038/nrc2694 · 2009 · External reference
Photo-triggered fluorescent theranostic prodrugs as DNA alkylating agents for mechlorethamine release and spatiotemporal monitoring
10.1039/c5ob00500k · 2015 · External reference
A FRET probe for the detection of alkylating agents
10.1039/c9cc04391h · 2019 · External reference
Synthesis and biological evaluation of naphthoquinone-coumarin conjugates as topoisomerase II inhibitors
10.1016/j.bmcl.2016.12.040 · 2017 · External reference
Novel conjugates of podophyllotoxin and coumarin: Synthesis, cytotoxicities, cell cycle arrest, binding CT DNA and inhibition of Topo IIbeta
10.1016/j.bmcl.2019.06.063 · 2019 · External reference
Design, synthesis, biological evaluation and molecular docking studies of novel 3-aryl-4-anilino-2H-chromen-2-one derivatives targeting ERalpha as anti-breast cancer agents
10.1016/j.bmcl.2017.04.029 · 2017 · External reference
7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ERalpha, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway
10.1007/s13105-018-0608-2 · 2018 · External reference
Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy
10.1016/j.bmc.2017.05.002 · 2017 · External reference
Design, synthesis and anticancer screening of 3-(3-(substituted phenyl) acryloyl)-2H-chromen-2ones as selective anti-breast cancer agent
10.1016/j.biopha.2017.02.089 · 2017 · External reference
Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis
10.2174/1871520619666190404155230 · 2019 · External reference
Synthesis of new coumarin tethered isoxazolines as potential anticancer agents
10.1016/j.bmcl.2018.10.046 · 2018 · External reference
Triazole tethered C5-curcuminoid-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies
10.1016/j.ejmech.2016.03.050 · 2016 · External reference
Esculin and its oligomer fractions inhibit adhesion and migration of U87 glioblastoma cells and in vitro angiogenesis
10.1007/s13277-015-4209-1 · 2016 · External reference
Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors
10.1021/acs.jmedchem.6b00158 · 2016 · External reference
Synthesis and evaluation of anticancer activity of 6-pyrazolinylcoumarin derivatives
10.1016/j.jsps.2016.05.005 · 2017 · External reference
Synthesis and biological evaluation of novel 4,7-dihydroxycoumarin derivatives as anticancer agents
10.1016/j.bmcl.2019.05.008 · 2019 · External reference
Novel SERMs based on 3-aryl-4-aryloxy-2H-chromen-2-one skeleton—A possible way to dual ERalpha/VEGFR-2 ligands for treatment of breast cancer
10.1016/j.ejmech.2017.09.015 · 2017 · External reference
Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis
10.1016/j.bioorg.2018.12.040 · 2019 · External reference
Synthesis and biological evaluation of morpholines linked coumarin-triazole hybrids as anticancer agents
10.1111/cbdd.13578 · 2019 · External reference
Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway
10.1016/j.ejphar.2017.08.025 · 2017 · External reference
Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
10.1080/14756366.2018.1477137 · 2018 · External reference
Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma
10.1016/j.bioorg.2019.03.003 · 2019 · External reference
Design, synthesis and biological evaluation of coumarin-3-carboxamides as selective carbonic anhydrase IX and XII inhibitors
10.1016/j.bioorg.2019.02.004 · 2019 · External reference
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII
10.1016/j.ejmech.2018.01.033 · 2018 · External reference
Novel sulfonamide bearing coumarin scaffolds as selective inhibitors of tumor associated carbonic anhydrase isoforms IX and XII
10.1016/j.bmc.2016.04.052 · 2016 · External reference
Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo
10.1016/j.ejmech.2016.02.009 · 2016 · External reference
Design and synthesis of 2-phenylpyrimidine coumarin derivatives as anticancer agents
10.1016/j.bmcl.2017.08.044 · 2017 · External reference
Enzyme inhibitory activities an insight into the structure-Activity relationship of biscoumarin derivatives
10.1016/j.ejmech.2017.10.009 · 2017 · External reference
Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells
10.3390/ijms22083830 · 2021 · External reference
Biscoumarin-pyrimidine conjugates as potent anticancer agents and binding mechanism of hit candidate with human serum albumin
10.1002/ardp.202000181 · 2021 · External reference
Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities
10.1016/j.bmcl.2015.10.063 · 2015 · External reference
Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives
10.3390/molecules200917614 · 2015 · External reference
Cellular effect of styrene substituted biscoumarin caused cellular apoptosis and cell cycle arrest in human breast cancer cells
10.1016/j.biocel.2017.09.019 · 2017 · External reference
Toward personalized cancer nanomedicine—past, present, and future
10.1039/c2ib20104f · 2013 · External reference
Transforming growth factor-beta-induced plasticity causes a migratory stemness phenotype in hepatocellular carcinoma
10.1016/j.canlet.2017.01.037 · 2017 · External reference
Ethanol extract of Ophiorrhiza pumila suppresses liver cancer cell proliferation and migration
2020 · External reference
Crossing the endothelial barrier during metastasis
10.1038/nrc3628 · 2013 · External reference
Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
10.3109/10799893.2015.1030412 · 2015 · External reference
TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells
2004 · External reference
DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway
10.3892/mmr.2012.1047 · 2012 · External reference
Inflammation and cancer: role of nuclear factor-kappaB activation
10.1111/j.1349-7006.2008.00763.x · 2008 · External reference
Clinicopathologic significance of expression of nuclear factor-kappaB RelA and its target gene products in gastric cancer patients
10.3748/wjg.v18.i34.4744 · 2012 · External reference
IL-17A/IL-17RA promotes invasion and activates MMP-2 and MMP-9 expression via p38 MAPK signaling pathway in non-small cell lung cancer
10.1007/s11010-018-3483-9 · 2019 · External reference
An Insight View on Synthetic Protocol, Mechanistic and Biological Aspects of Biscoumarin Derivatives
10.1002/slct.201903632 · 2019 · External reference
