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References from Retinoic acid alleviates the reduction of Akt and Bad phosphorylation and regulates Bcl-2 family protein interactions in animal models of ischemic stroke. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathophysiology and treatment of stroke: present status and future perspectives
10.3390/ijms21207609 · 2020 · External reference
Biological functions and regulatory mechanisms of hypoxia-inducible factor-1α in ischemic stroke
10.3389/fimmu.2021.801985 · 2021 · External reference
The role of the ATP-adenosine axis in ischemic stroke
10.1007/s00281-023-00987-3 · 2023 · External reference
Systemic inflammation after stroke: implications for post-stroke comorbidities
10.15252/emmm.202216269 · 2022 · External reference
Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells
10.1186/1476-4598-12-44 · 2013 · External reference
Retinoic acid-induced regulation of inflammatory pathways is a potential sepsis treatment
10.1128/iai.00457-22 · 2023 · External reference
Anti-inflammatory effect of retinoic acid on experimental autoimmune uveoretinitis
10.1136/bjo.2009.171314 · 2010 · External reference
Retinoic acid induced the differentiation of neural stem cells from embryonic spinal cord into functional neurons in vitro
2015 · External reference
Bailey SJ. Role of retinoid signaling in the adult brain
10.1016/j.pneurobio.2005.03.002 · 2005 · External reference
Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease.
2019 · External reference
Vitamin A bio-modulates apoptosis via the mitochondrial pathway after hypoxic-ischemic brain damage
10.1186/s13041-018-0360-0 · 2018 · External reference
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
10.1038/s41467-021-23752-2 · 2021 · External reference
The PI3K/AKT pathway in obesity and type 2 diabetes
10.7150/ijbs.27173 · 2018 · External reference
Akt: a potential drug target for metabolic syndrome.
10.3389/fphys.2022.822333 · 2022 · External reference
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
10.1038/s41467-022-29368-4 · 2022 · External reference
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
10.1016/s0092-8674(00)80595-4 · 1999 · External reference
Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats
10.1038/sj.jcbfm.9600303 · 2006 · External reference
Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
10.1023/a:1011319901057 · 2001 · External reference
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
10.1016/s1097-2765(05)00012-2 · 2000 · External reference
How BAD phosphorylation is good for survival
10.1038/10026 · 1999 · External reference
14-3-3 proteins mediate an essential anti-apoptotic signal
10.1074/jbc.m105971200 · 2001 · External reference
Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL
10.15698/mic2016.12.547 · 2016 · External reference
Mechanisms of cytochrome c release from mitochondria
10.1038/sj.cdd.4401950 · 2006 · External reference
14-3-3 inhibits Bad-induced cell death through interaction with serine-136
10.1124/mol.60.6.1325 · 2001 · External reference
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death
10.1073/pnas.1202810109 · 2012 · External reference
Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries
10.1523/jneurosci.5661-12.2013 · 2013 · External reference
Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia
10.1074/jbc.m505804200 · 2005 · External reference
Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment
External reference
The emerging role of Nrf2 in mitochondrial function
10.1016/j.freeradbiomed.2015.04.036 · 2015 · External reference
CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways
10.1016/j.nbd.2018.05.011 · 2019 · External reference
Role of mTORC1 controlling proteostasis after brain ischemia
10.3389/fnins.2018.00060 · 2018 · External reference
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha
10.1016/j.expneurol.2004.01.030 · 2004 · External reference
Retinoic acid protects against proteasome inhibition associated cell death in SH-SY5Y cells via the AKT pathway
10.1016/j.neuint.2012.10.014 · 2013 · External reference
All-trans retinoic acid modulates Wnt3A-induced osteogenic differentiation of mesenchymal stem cells via activating the PI3K/AKT/GSK3β signalling pathway.
10.1016/j.mce.2015.12.018 · 2016 · External reference
Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells
10.1152/ajpcell.00034.2009 · 2009 · External reference
Electroacupuncture inhibits neuronal autophagy and apoptosis via the PI3K/AKT pathway following ischemic stroke.
10.3389/fncel.2020.00134 · 2020 · External reference
The PI3K/AKT pathway-the potential key mechanisms of traditional chinese medicine for stroke
2022 · External reference
Retinoic acid ameliorates blood-brain barrier disruption following ischemic stroke in rats
10.1016/j.phrs.2015.05.014 · 2015 · External reference
Retinoic acid exerts neuroprotective effects against focal cerebral ischemia by preventing apoptotic cell death
10.1016/j.neulet.2021.135979 · 2021 · External reference
Reversible middle cerebral artery occlusion without craniectomy in rats
10.1161/01.str.20.1.84 · 1989 · External reference
Retinoic acid regulates the ubiquitin-proteasome system in a middle cerebral artery occlusion animal model
10.1186/s42826-022-00123-6 · 2022 · External reference
Behavioral tests in rodent models of stroke
10.1016/j.hest.2020.09.001 · 2020 · External reference
Cognitive deficits after focal cerebral ischemia in mice
10.1161/01.str.31.8.1939 · 2000 · External reference
Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice.
10.1038/srep42323 · 2017 · External reference
Unresolved reference
2005 · External reference
Inhibiting PI3K/Akt-signaling pathway improves neurobehavior changes in anti-NMDAR encephalitis mice by ameliorating blood-brain barrier disruption and neuronal damage
10.1007/s10571-023-01371-3 · 2023 · External reference
The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat
10.1161/atvbaha.107.150748 · 2007 · External reference
Neuroprotection signaling of nuclear akt in neuronal cells.
10.5607/en.2014.23.3.200 · 2004 · External reference
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
10.1016/j.cellsig.2014.08.019 · 2014 · External reference
Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke
10.1385/mn:34:3:249 · 2006 · External reference
Gingko biloba Extract (EGb 761) prevents ischemic brain injury by activation of the Akt signaling pathway.
10.1142/s0192415x09007041 · 2009 · External reference
Melatonin prevents hepatic injury-induced decrease in Akt downstream targets phosphorylations
10.1111/j.1600-079x.2011.00879.x · 2011 · External reference
Ferulic acid prevents the cerebral ischemic injury-induced decrease of Akt and Bad phosphorylation
10.1016/j.neulet.2011.12.012 · 2012 · External reference
Estradiol attenuates the focal cerebral ischemic injury through mTOR/p70S6 kinase signaling pathway
10.1016/j.neulet.2008.02.061 · 2008 · External reference
Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer
10.1186/s12964-024-01492-2 · 2024 · External reference
The Effect of Retinoic Acid on Arsenite-Transformed Malignant UROtsa Bladder Cancer Cells: In Vitro Model of Basal Muscle-Invasive Bladder Cancer.
10.3390/cancers16061178 · 2024 · External reference
All-trans retinoic acid exerts neuroprotective effects in amyotrophic lateral sclerosis-like Tg (SOD1*G93A)1Gur mice.
10.1007/s12035-020-01973-8 · 2020 · External reference
Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson’s disease.
10.3389/fnagi.2015.00020 · 2015 · External reference
All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling.
10.1186/s12974-019-1557-6 · 2019 · External reference
PI3K/AKT signal pathway: A target of natural products in the prevention and treatment of Alzheimer’s disease and Parkinson’s disease.
10.3389/fphar.2021.648636 · 2021 · External reference
The PI3K-AKT pathway: A plausible therapeutic target in Parkinson’s disease
10.1016/j.yexmp.2022.104846 · 2023 · External reference
14-3-3 interacts directly with and negatively regulates pro-apoptotic Bax
10.1074/jbc.m207880200 · 2003 · External reference
