Research graph
References from Sphingosine-1-phosphate promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020.
10.1111/hepr.13688 · 2021 · External reference
The epidemiology of non-alcoholic fatty liver disease
10.1111/liv.13299 · 2017 · External reference
Pathology of non-alcoholic fatty liver disease
10.1111/liv.13301 · 2017 · External reference
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
10.1053/j.gastro.2015.04.043 · 2015 · External reference
Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis
10.1053/j.gastro.2018.06.031 · 2018 · External reference
Platelet-activating factor in liver injury: a relational scope
10.3748/wjg.v12.i23.3695 · 2006 · External reference
TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes
10.4049/jimmunol.167.1.173 · 2001 · External reference
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer
2013 · External reference
Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.
10.1096/fj.10-168351 · 2011 · External reference
Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice.
10.1038/srep13423 · 2015 · External reference
The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice
10.1002/hep.29076 · 2017 · External reference
Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2
10.1194/jlr.m800496-jlr200 · 2009 · External reference
Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration
10.1074/jbc.m115.671735 · 2015 · External reference
Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy
10.1002/hep.32256 · 2022 · External reference
Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis
10.1152/ajpgi.00222.2016 · 2017 · External reference
Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis
10.1038/nmat5024 · 2017 · External reference
Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients.
10.1186/s12876-021-01633-8 · 2021 · External reference
Angiopoietin-2 Promotes Pathological Angiogenesis and Is a Therapeutic Target in Murine Nonalcoholic Fatty Liver Disease
10.1002/hep.30294 · 2019 · External reference
S1P control of endothelial integrity
2014 · External reference
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
10.1111/j.1572-0241.1999.01377.x · 1999 · External reference
Head group specificity in the requirement of phosphatidylcholine biosynthesis for very low density lipoprotein secretion from cultured hepatocytes
10.1016/s0021-9258(18)60474-0 · 1989 · External reference
The Role of Cholesterol in the Pathogenesis of NASH
10.1016/j.tem.2015.11.008 · 2016 · External reference
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha
10.1074/jbc.m503002200 · 2005 · External reference
Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet
10.1016/j.jnutbio.2015.04.004 · 2015 · External reference
A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase
10.1074/jbc.m609641200 · 2007 · External reference
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity
10.1016/j.jbc.2021.101470 · 2022 · External reference
Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop
10.1096/fj.201601183r · 2017 · External reference
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy
10.1126/science.aar5551 · 2019 · External reference
Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling.
10.1016/j.celrep.2019.11.036 · 2019 · External reference
Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
10.1172/jci84871 · 2016 · External reference
Tie1 controls angiopoietin function in vascular remodeling and inflammation
10.1172/jci84923 · 2016 · External reference
L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin
10.1074/jbc.m111.235473 · 2011 · External reference
Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis
10.2337/dc17-1318 · 2018 · External reference
Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1alpha-dependent manner
10.1194/jlr.m063412 · 2016 · External reference
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
10.1074/jbc.m510660200 · 2006 · External reference
Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells
10.1111/j.1872-034x.2008.00485.x · 2009 · External reference
Fatty acid-mediated activation of vascular endothelial cells
10.1053/meta.2000.7736 · 2000 · External reference
