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References from VDX-111 targets proliferative pathways in canine cancer cell lines. Local targets link to admitted publications; unresolved targets remain external evidence.
Vitamin D and its synthetic analogs
10.1021/acs.jmedchem.9b00208 · 2019 · External reference
Exploring vitamin D metabolism and function in cancer
2018 · External reference
The role of vitamin D in reducing cancer risk and progression.
2014 · External reference
An update on vitamin D signaling and cancer.
2022 · External reference
1,25-dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade
10.1016/j.intimp.2013.08.009 · 2013 · External reference
Unresolved reference
2001 · External reference
1α,25-Dihydroxyvitamin D3-3β-bromoacetate, a potential cancer therapeutic agent: Synthesis and molecular mechanism of action
10.1016/j.bmcl.2011.02.025 · 2011 · External reference
A vitamin D receptor-alkylating derivative of 1α,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth
10.1158/1940-6207.capr-10-0122 · 2010 · External reference
Unresolved reference
2016 · External reference
Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth
10.1038/oncsis.2016.50 · 2016 · External reference
PRL-3 engages the focal adhesion pathway in triple-negative breast cancer cells to alter actin structure and substrate adhesion properties critical for cell migration and invasion
10.1016/j.canlet.2016.07.017 · 2016 · External reference
Pan-cancer whole-genome analyses of metastatic solid tumours
10.1038/s41586-019-1689-y · 2019 · External reference
The pathogenic role of PI3K/AKT pathway in cancer onset and drug resistance: an updated review.
2021 · External reference
Targeting PI3K in cancer: Mechanisms and advances in clinical trials.
2019 · External reference
Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds.
2021 · External reference
Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics.
10.1038/s41598-023-37505-2 · 2023 · External reference
MAP kinase signalling pathways in cancer
10.1038/sj.onc.1210421 · 2007 · External reference
The MAPK pathway across different malignancies: A new perspective.
2014 · External reference
Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer
10.1158/0008-5472.can-13-2820 · 2014 · External reference
Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1
10.4049/jimmunol.1102412 · 2012 · External reference
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing
10.1158/1535-7163.mct-18-1346 · 2019 · External reference
Canine Cancer Genomics: Lessons for Canine and Human Health.
10.1146/annurev-animal-030117-014523 · 2019 · External reference
Canine Cancer: Strategies in Experimental Therapeutics.
2019 · External reference
Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma.
2021 · External reference
Characterizing the molecular and immune landscape of canine bladder cancer
10.1111/vco.12740 · 2022 · External reference
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation
10.1177/1040638711408064 · 2011 · External reference
Trimmomatic: A flexible trimmer for Illumina sequence data
10.1093/bioinformatics/btu170 · 2014 · External reference
STAR: Ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
2014 · External reference
fdrtool: A versatile R package for estimating local and tail area-based false discovery rates
10.1093/bioinformatics/btn209 · 2008 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
2019 · External reference
G:Profiler: A web server for functional enrichment analysis and conversions of gene lists (2019 update).
10.1093/nar/gkz369 · 2019 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
2014 · External reference
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles.
10.1073/pnas.0506580102 · 2005 · External reference
The Flint Animal Cancer Center (FACC) Canine Tumour Cell Line Panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
10.1111/vco.12192 · 2017 · External reference
The Genetic and Molecular Basis for Canine Models of Human Leukemia and Lymphoma.
2020 · External reference
Understanding the osteosarcoma pathobiology: A comparative oncology approach.
2016 · External reference
Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2.
2019 · External reference
MYC protein interactors in gene transcription and cancer.
10.1038/s41568-021-00367-9 · 2021 · External reference
Canine mammary tumours are affected by frequent copy number aberrations, Including amplification of myc and loss of pten.
2015 · External reference
Suppression of MYC by PI3K/AKT/mTOR pathway inhibition in combination with all-trans retinoic acid treatment for therapeutic gain in acute myeloid leukaemia
10.1111/bjh.18187 · 2022 · External reference
The PI3K/AKT/c-MYC Axis Promotes the Acquisition of Cancer Stem-Like Features in Esophageal Squamous Cell Carcinoma
10.1002/stem.2395 · 2016 · External reference
Unresolved reference
2008 · External reference
Histone modifications and cancer
2016 · External reference
Chromatin and Cancer: Implications of Disrupted Chromatin Organization in Tumorigenesis and Its Diversification.
2023 · External reference
Epigenetic regulation of the PTEN-AKT-RAC1 Axis by G9a is critical for tumor growth in alveolar rhabdomyosarcoma
10.1158/0008-5472.can-18-2676 · 2019 · External reference
The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.
2017 · External reference
Vitamin D and the epigenome.
2014 · External reference
Vitamin D signaling in inflammation and cancer: Molecular mechanisms and therapeutic implications.
2020 · External reference
Vitamin D metabolism, mechanism of action, and clinical applications.
2014 · External reference
