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References from Identification of potential anti-tumor targets and mechanisms of HuaChanSu injection using network pharmacology and cytological experiments in Breast cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 · External reference
Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue
10.3390/ijms22094673 · 2021 · External reference
Traditional Chinese medicine and cancer: History, present situation, and development
10.1111/1759-7714.12270 · 2015 · External reference
Unlocking the Mystery of the Therapeutic Effects of Chinese Medicine on Cancer
2020 · External reference
Sanyin Formula Enhances the Therapeutic Efficacy of Paclitaxel in Triple-Negative Breast Cancer Metastases through the JAK/STAT3 Pathway in Mice
10.3390/ph16010009 · 2023 · External reference
Huachansu suppresses TRPV1 up-regulation and spinal astrocyte activation to prevent oxaliplatin-induced peripheral neuropathic pain in rats
10.1016/j.gene.2018.09.035 · 2019 · External reference
New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin
10.1186/s12935-019-0806-1 · 2019 · External reference
Efficacy and safety of Huachansu combined with chemotherapy in advanced gastric cancer: a meta-analysis
10.1016/j.mehy.2013.04.038 · 2013 · External reference
Is Huachansu Beneficial in Treating Advanced Non-Small-Cell Lung Cancer? Evidence from a Meta-Analysis of Its Efficacy Combined with Chemotherapy
10.1155/2015/408145 · 2015 · External reference
Huachansu injection inhibits metastasis of pancreatic cancer in mice model of human tumor xenograft
10.1186/1472-6882-14-483 · 2014 · External reference
Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer
10.1002/cncr.24602 · 2009 · External reference
Comparative analysis of the bufonis venenum by using TLC, HPLC, and LC-MS for different extraction methods
10.3831/kpi.2012.15.012 · 2012 · External reference
Huachansu Capsule inhibits the proliferation of human gastric cancer cells via Akt/mTOR pathway
10.1016/j.biopha.2019.109241 · 2019 · External reference
Efficacy and safety of Huachansu combined with chemotherapy in advanced gastric cancer: A meta-analysis
10.1016/j.mehy.2013.04.038 · 2013 · External reference
Huachansu, containing cardiac glycosides, enhances radiosensitivity of human lung cancer cells
2011 · External reference
Cyto-/genotoxic effects of the ethanol extract of Chan Su, a traditional Chinese medicine, in human cancer cell lines
10.1016/j.jep.2014.01.023 · 2014 · External reference
High Resolution Mass Profile of Bufadienolides and Peptides Combing with Anti-Tumor Cell Screening and Multivariate Analysis for the Quality Evaluation of Bufonis Venenum
10.3390/molecules24101943 · 2019 · External reference
Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor
10.1016/j.intimp.2010.12.007 · 2011 · External reference
Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment
10.15698/cst2020.07.224 · 2020 · External reference
Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry and HPLC-photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections
10.1002/jssc.201200762 · 2013 · External reference
Simultaneous determination of eight bufadienolides in cinobufacini injection by HPLC coupled with triple quadrupole mass spectrometry
10.1002/jssc.201200036 · 2012 · External reference
Evaluation of AutoDock and AutoDock Vina on the CASF-2013 Benchmark
10.1021/acs.jcim.8b00312 · 2018 · External reference
Minoxidil topical treatment may be more efficient if applied on damp scalp in comparison with dry scalp
2016 · External reference
Progressive alopecia associated with dry scalp: preliminary observations
1970 · External reference
Determination of bufothionine in skin of Bufo bufo gargarizans and Huachansu injection
2007 · External reference
Transcatheter hepatic arterial chemoembolization plus cinobufotalin injection adjuvant therapy for advanced hepatocellular carcinoma: a meta-analysis of 27 trials involving 2,079 patients
10.2147/ott.s182840 · 2018 · External reference
Cutaneous manifestations in anorexia nervosa
2000 · External reference
Safety reassessment of cinobufotalin injection: new findings into cardiotoxicity
10.1093/toxres/tfaa035 · 2020 · External reference
Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer
10.1155/2020/1246742 · 2020 · External reference
The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin
10.2147/ccid.s158428 · 2018 · External reference
Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo.
10.1186/s13046-015-0134-9 · 2015 · External reference
HuaChanSu suppresses tumor growth and interferes with glucose metabolism in hepatocellular carcinoma cells by restraining Hexokinase-2.
10.1016/j.biocel.2021.106123 · 2022 · External reference
Huachansu mediates cell death in non-Hodgkin’s lymphoma by induction of caspase-3 and inhibition of MAP kinase
10.3892/ijo.2015.3044 · 2015 · External reference
Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective
10.1007/s11655-019-3064-0 · 2020 · External reference
How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?
10.3390/molecules22071135 · 2017 · External reference
Integrating Network Pharmacology and Metabolomics Study on Anti-rheumatic Mechanisms and Antagonistic Effects Against Methotrexate-Induced Toxicity of Qing-Luo-Yin
10.3389/fphar.2018.01472 · 2018 · External reference
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells
10.1021/acssynbio.8b00237 · 2019 · External reference
Traditional Chinese medicine network pharmacology: development in new era under guidance of network pharmacology evaluation method guidance
2022 · External reference
PI3K/AKT/mTOR signalling pathway involvement in renal cell carcinoma pathogenesis (Review)
10.3892/etm.2021.9972 · 2021 · External reference
Akt signaling and cancer: surviving but not moving on
10.1158/0008-5472.can-06-0743 · 2006 · External reference
Akt in cancer: Mediator and more
10.1016/j.semcancer.2019.06.002 · 2019 · External reference
PI3K/Akt/mTOR Intracellular Pathway and Breast Cancer: Factors, Mechanism and Regulation
10.2174/1381612823666161116125218 · 2017 · External reference
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects
10.3390/ijms22010173 · 2020 · External reference
Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer
10.1007/s40265-020-01394-w · 2020 · External reference
Design, synthesis and anti-tumor activities of carbamate derivatives of cinobufagin
10.1016/j.steroids.2020.108749 · 2020 · External reference
Cinobufagin induces cell cycle arrest at the S phase and promotes apoptosis in nasopharyngeal carcinoma cells
10.1016/j.biopha.2019.109763 · 2020 · External reference
Differentially expressed gene profile and relevant pathways of the traditional Chinese medicine cinobufotalin on MCF‑7 breast cancer cells
2019 · External reference
Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells
10.1016/j.jep.2022.115095 · 2022 · External reference
Inhibitory Impact Of Cinobufagin In Triple-Negative Breast Cancer Metastasis: Involvements Of Macrophage Reprogramming Through Upregulated MME and Inactivated FAK/STAT3 Signaling
2024 · External reference
Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells
10.18632/oncotarget.7898 · 2016 · External reference
Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells
10.1016/j.jep.2010.02.022 · 2010 · External reference
Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients.
10.7314/apjcp.2012.13.11.5339 · 2012 · External reference
Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent
10.1016/j.bbrc.2014.08.147 · 2014 · External reference
ψ-Bufarenogin, a lead compound of anti-cancer drug
10.1080/15384101.2015.1071139 · 2015 · External reference
Comparison of affinity ranking using AutoDock-GPU and MM-GBSA scores for BACE-1 inhibitors in the D3R Grand Challenge 4
10.1007/s10822-019-00240-w · 2019 · External reference
