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References from Cigarette smoke sustains immunosuppressive microenvironment inducing M2 macrophage polarization and viability in lung cancer settings. Local targets link to admitted publications; unresolved targets remain external evidence.
Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018
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The state of molecular biomarkers for the early detection of lung cancer
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Treatment of non-small cell lung cancer (NSCLC)
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Genetic susceptibility to lung cancer—light at the end of the tunnel?
10.1093/carcin/bgt016 · 2013 · External reference
Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice
10.1093/toxsci/kfr187 · 2011 · External reference
Erlotinib in previously treated non-small-cell lung cancer
10.1056/nejmoa050753 · 2005 · External reference
Cancer statistics, 2013
10.3322/caac.21166 · 2013 · External reference
Lung cancer incidence in never smokers
10.1200/jco.2006.07.2983 · 2007 · External reference
Non-Smoking-Associated Lung Cancer: A distinct Entity in Terms of Tumor Biology, Patient Characteristics and Impact of Hereditary Cancer Predisposition
10.3390/cancers11020204 · 2019 · External reference
Inherited lung cancer: a review
2020 · External reference
Smoker and non-smoker lung adenocarcinoma is characterized by distinct tumor immune microenvironments
10.1080/2162402x.2018.1494677 · 2018 · External reference
Impact of smoking on inflammation: overview of molecular mechanisms
10.1007/s00011-011-0308-7 · 2011 · External reference
Alveolar Macrophages in the Resolution of Inflammation, Tissue Repair, and Tolerance to Infection
10.3389/fimmu.2018.01777 · 2018 · External reference
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
10.1016/j.cell.2018.05.060 · 2018 · External reference
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
10.1016/s1471-4906(02)02302-5 · 2002 · External reference
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
10.1189/jlb.0609385 · 2009 · External reference
The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time
10.1186/1471-2407-10-112 · 2010 · External reference
Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small Cell Lung Carcinoma
10.1158/0008-5472.can-20-0069 · 2020 · External reference
Toll-like receptor agonists in cancer therapy
10.2217/imt.09.70 · 2009 · External reference
Trial Watch: Toll-like receptor agonists in cancer immunotherapy
10.1080/2162402x.2018.1526250 · 2018 · External reference
The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
10.3389/fimmu.2019.02388 · 2019 · External reference
Harnessing the immune system to fight cancer with Toll-like receptor and RIG-I-like receptor agonists
10.1016/j.phrs.2019.03.001 · 2020 · External reference
Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
10.1073/pnas.1113099109 · 2012 · External reference
TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression
10.3389/fimmu.2018.01650 · 2018 · External reference
Toll-like receptor 3 as a new marker to detect high risk early stage Non-Small-Cell Lung Cancer patients
10.1038/s41598-019-50756-2 · 2019 · External reference
Fhit Nuclear Import Following EGF Stimulation Sustains Proliferation of Breast Cancer Cells
10.1002/jcp.24968 · 2015 · External reference
CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers
10.18632/oncotarget.11935 · 2016 · External reference
3D-spheroids: What can they tell us about pancreatic ductal adenocarcinoma cell phenotype?
10.1016/j.yexcr.2017.05.027 · 2017 · External reference
Mechanical Cues, E-Cadherin Expression and Cell "Sociality" Are Crucial Crossroads in Determining Pancreatic Ductal Adenocarcinoma Cells Behavior
10.3390/cells11081318 · 2022 · External reference
Vitamin C prevents cigarette smoke induced oxidative damage of proteins and increased proteolysis
10.1016/s0891-5849(99)00154-9 · 1999 · External reference
Activation of NK cell cytotoxicity by aerosolized CpG-ODN/poly(I:C) against lung melanoma metastases is mediated by alveolar macrophages
10.1016/j.cellimm.2017.01.004 · 2017 · External reference
TLR3 Expression Induces Apoptosis in Human Non-Small-Cell Lung Cancer
10.3390/ijms21041440 · 2020 · External reference
Macrophage activation and polarization: nomenclature and experimental guidelines
10.1016/j.immuni.2014.06.008 · 2014 · External reference
Macrophage Polarization in Physiological and Pathological Pregnancy
10.3389/fimmu.2019.00792 · 2019 · External reference
Protein carbonylation in human endothelial cells exposed to cigarette smoke extract
10.1016/j.toxlet.2013.01.023 · 2013 · External reference
Protein carbonylation in human bronchial epithelial cells exposed to cigarette smoke extract
10.1007/s10565-019-09460-0 · 2019 · External reference
A murine model of cigarette smoke-induced pulmonary inflammation using intranasally administered smoke-conditioned medium
10.1080/01902140290096728 · 2002 · External reference
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
10.1038/ni.1937 · 2010 · External reference
Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor
10.1016/j.molcel.2019.10.023 · 2020 · External reference
Tumor cells-derived conditioned medium induced pro-tumoral phenotypes in macrophages through calcium-nuclear factor κB interaction
10.1186/s12885-022-10431-8 · 2022 · External reference
Generation of monocyte-derived tumor-associated macrophages using tumor-conditioned media provides a novel method to study tumor-associated macrophages in vitro
10.1186/s40425-019-0622-0 · 2019 · External reference
M-1/M-2 macrophages and the Th1/Th2 paradigm
10.4049/jimmunol.164.12.6166 · 2000 · External reference
The chemokine system in diverse forms of macrophage activation and polarization
10.1016/j.it.2004.09.015 · 2004 · External reference
Cellular Metabolism and Macrophage Functional Polarization
10.3109/08830185.2014.969421 · 2015 · External reference
The M1 and M2 paradigm of macrophage activation: time for reassessment
10.12703/p6-13 · 2014 · External reference
Type I interferon corrected gene induction by the interferon regulatory factor family of transcription factors
10.1016/j.immuni.2006.08.009 · 2006 · External reference
IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo
10.1186/s12974-016-0596-5 · 2016 · External reference
Involvement of JNK signaling in IL4-induced M2 macrophage polarization
10.1016/j.yexcr.2017.05.010 · 2017 · External reference
Induction of murine macrophage M2 polarization by cigarette smoke extract via the JAK2/STAT3 pathway
10.1371/journal.pone.0107063 · 2014 · External reference
M2 polarized macrophages induced by CSE promote proliferation, migration, and invasion of alveolar basal epithelial cells
10.1016/j.intimp.2015.07.033 · 2015 · External reference
Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages
10.1186/1476-9255-6-12 · 2009 · External reference
Regulation of Cigarette Smoke Induction of IL-8 in Macrophages by AMP-activated Protein Kinase Signaling
10.1002/jcp.24881 · 2015 · External reference
Effect of CSE on M1/M2 polarization in alveolar and peritoneal macrophages at different concentrations and exposure in vitro
10.1007/s11626-019-00426-4 · 2020 · External reference
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease
10.4049/jimmunol.0900473 · 2009 · External reference
Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity
10.1186/s12931-017-0522-0 · 2017 · External reference
Next generation immune-checkpoints for cancer therapy
10.21037/jtd.2018.02.79 · 2018 · External reference
Innate immune checkpoints for cancer immunotherapy: expanding the scope of non T cell targets
10.21037/atm-20-1816 · 2020 · External reference
Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies
10.1038/s41392-020-00347-9 · 2020 · External reference
Top 10 Challenges in Cancer Immunotherapy
10.1016/j.immuni.2019.12.011 · 2020 · External reference
The Resistance Mechanisms of Lung Cancer Immunotherapy
10.3389/fonc.2020.568059 · 2020 · External reference
Aerosol 1,25-dihydroxyvitamin D3 supplementation: A strategy to boost anti-tumor innate immune activity
10.1371/journal.pone.0248789 · 2021 · External reference
TLR signaling
10.1016/j.smim.2006.12.004 · 2007 · External reference
Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses
10.1042/bj20131492 · 2014 · External reference
Exploiting poly(I:C) to induce cancer cell apoptosis
10.1080/15384047.2017.1373220 · 2017 · External reference
Macrophages Impair TLR9 Agonist Antitumor Activity through Interacting with the Anti-PD-1 Antibody Fc Domain
10.3390/cancers13164081 · 2021 · External reference
The exploitation of Toll-like receptor 3 signaling in cancer therapy
10.2174/1381612820666140826153347 · 2014 · External reference
Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy
10.1080/2162402x.2015.1088631 · 2016 · External reference
Reprogramming the lung microenvironment by inhaled immunotherapy fosters immune destruction of tumor
10.1080/2162402x.2016.1234571 · 2016 · External reference
Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma
10.1080/2162402x.2021.1956143 · 2021 · External reference
Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages
10.3389/fimmu.2017.01383 · 2017 · External reference
Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages
10.1111/cei.12289 · 2014 · External reference
Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice
10.1152/ajplung.00201.2005 · 2006 · External reference
Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent
10.4049/jimmunol.180.2.1169 · 2008 · External reference
Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages
10.1111/j.1440-1843.2012.02198.x · 2012 · External reference
In Vivo and In Vitro Studies of Cigarette Smoke Effects on Innate Responses to Influenza Virus: A Matter of Models?
2022 · External reference
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses
10.1186/s12931-016-0428-2 · 2016 · External reference
Maternal smoking is associated with impaired neonatal toll-like-receptor-mediated immune responses
10.1183/09031936.06.00050206 · 2006 · External reference
Second-hand cigarette smoke impairs bacterial phagocytosis in macrophages by modulating CFTR dependent lipid-rafts
10.1371/journal.pone.0121200 · 2015 · External reference
Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression
10.1186/1465-9921-14-33 · 2013 · External reference
Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage
10.1152/ajplung.00406.2017 · 2018 · External reference
TLRs in pulmonary diseases
10.1016/j.lfs.2019.116671 · 2019 · External reference
Macrophages: Their role, activation and polarization in pulmonary diseases
10.1016/j.imbio.2017.11.001 · 2018 · External reference
Current views of toll-like receptor signaling pathways
10.1155/2010/240365 · 2010 · External reference
TLR signaling pathways
10.1016/j.smim.2003.10.003 · 2004 · External reference
Pattern recognition receptors and inflammation
10.1016/j.cell.2010.01.022 · 2010 · External reference
