Research graph
References from KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B. Local targets link to admitted publications; unresolved targets remain external evidence.
Getting to HBV cure: The promising paths forward
10.1002/hep.32314 · 2022 · External reference
Mechanisms of Hepatitis B Virus Persistence
10.1016/j.tim.2017.07.006 · 2018 · External reference
Therapeutic strategies for hepatitis B virus infection: towards a cure
10.1038/s41573-019-0037-0 · 2019 · External reference
How to achieve functional cure of HBV: Stopping NUCs, adding interferon or new drug development?
10.1016/j.jhep.2021.11.024 · 2022 · External reference
Adaptive immunity in HBV infection
10.1016/j.jhep.2016.01.026 · 2016 · External reference
Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection
10.1016/s0016-5085(99)70289-1 · 1999 · External reference
Hepatitis B virus infection.
10.1038/nrdp.2018.35 · 2018 · External reference
T-cell exhaustion: characteristics, causes and conversion
10.1111/j.1365-2567.2010.03255.x · 2010 · External reference
Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro
10.1136/gutjnl-2022-327202 · 2023 · External reference
Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes
10.1084/jem.187.9.1383 · 1998 · External reference
Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection
10.1182/blood.v96.9.3094 · 2000 · External reference
High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function
10.1002/1521-4141(200103)31:3<677::aid-immu677>3.0.co;2-m · 2001 · External reference
Analysis of successful immune responses in persons infected with hepatitis C virus
10.1084/jem.191.9.1499 · 2000 · External reference
T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance
10.1038/cddis.2015.42 · 2015 · External reference
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
10.1038/ni1443 · 2007 · External reference
CD8(+) T cells in human autoimmune arthritis: the unusual suspects
10.1038/nrrheum.2016.74 · 2016 · External reference
Interaction of KLRG1 with E-cadherin: new functional and structural insights
10.1002/eji.200838690 · 2008 · External reference
Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs
10.1182/blood-2011-10-384289 · 2012 · External reference
CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo
2019 · External reference
TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection
2020 · External reference
Epithelial adhesion molecules can inhibit HIV-1-specific CD8(+) T-cell functions
10.1182/blood-2010-12-321588 · 2011 · External reference
Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation
10.1128/jvi.79.18.12112-12116.2005 · 2005 · External reference
Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57
10.4049/jimmunol.174.10.6088 · 2005 · External reference
Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B
10.1016/j.jhep.2018.05.004 · 2018 · External reference
Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation
10.1016/j.jhep.2014.07.005 · 2014 · External reference
Electronic address eee, European Association for the Study of the L. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection
10.1016/j.jhep.2017.03.021 · 2017 · External reference
Functional reconstitution of HBV-specific CD8 T cells by in vitro polyphenol treatment in chronic hepatitis B
10.1016/j.jhep.2020.10.034 · 2021 · External reference
Low-level viremia and the increased risk of hepatocellular carcinoma in patients receiving entecavir treatment
10.1002/hep.28916 · 2017 · External reference
Transcriptional Pattern Analysis of Virus-Specific CD8+ T Cells in Hepatitis C Infection: Increased Expression of TOX and Eomesodermin During and After Persistent Antigen Recognition
10.3389/fimmu.2022.886646 · 2022 · External reference
T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection
10.1371/journal.ppat.1004251 · 2014 · External reference
Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory
10.1016/j.immuni.2012.08.021 · 2012 · External reference
T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections
10.1016/j.immuni.2016.07.021 · 2016 · External reference
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
10.1016/j.immuni.2019.09.013 · 2019 · External reference
Memory T cells: strategies for optimizing tumor immunotherapy
10.1007/s13238-020-00707-9 · 2020 · External reference
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
10.1016/j.immuni.2007.07.010 · 2007 · External reference
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF
10.1038/nm.2232 · 2010 · External reference
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
10.1126/science.aaf2807 · 2016 · External reference
Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition
10.1016/j.immuni.2009.04.019 · 2009 · External reference
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
10.1016/j.immuni.2016.07.011 · 2016 · External reference
Defining ’T cell exhaustion
10.1038/s41577-019-0221-9 · 2019 · External reference
NK-cell exhaustion, B-cell exhaustion and T-cell exhaustion-the differences and similarities
10.1111/imm.13464 · 2022 · External reference
NK Cell Exhaustion
10.3389/fimmu.2017.00760 · 2017 · External reference
Comparative characterization of B cells specific for HBV nucleocapsid and envelope proteins in patients with chronic hepatitis B
10.1016/j.jhep.2019.07.015 · 2020 · External reference
TIGIT(+) TIM-3(+) NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinoma
10.1080/2162402x.2021.1942673 · 2021 · External reference
Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161(++)TCR iVα7.2(+) Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection
10.3389/fimmu.2018.00472 · 2018 · External reference
Mucosal-associated invariant T-cells are severely reduced and exhausted in humans with chronic HBV infection
10.1111/jvh.13341 · 2020 · External reference
Elevated Hepatic CD1d Levels Coincide with Invariant NKT Cell Defects in Chronic Hepatitis B Virus Infection
10.4049/jimmunol.1701801 · 2018 · External reference
Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
10.1136/gutjnl-2018-316641 · 2019 · External reference
Transcription factor regulation of CD8+ T-cell memory and exhaustion
10.1111/j.1600-065x.2010.00927.x · 2010 · External reference
Expression of immune checkpoints and T cell exhaustion markers in early and advanced stages of colorectal cancer
10.1007/s00262-020-02593-w · 2020 · External reference
Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS
10.1371/journal.pone.0215991 · 2019 · External reference
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
10.1371/journal.ppat.1000947 · 2010 · External reference
KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during gamma-herpesvirus infection
10.4049/jimmunol.1003122 · 2011 · External reference
The Fate Choice Between Effector and Memory T Cell Lineages: Asymmetry, Signal Integration, and Feedback to Create Bistability
10.1016/bs.ai.2017.12.003 · 2018 · External reference
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
10.1038/ni1009 · 2003 · External reference
Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection
10.1038/nature19317 · 2016 · External reference
Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy
10.1186/s12885-021-08510-3 · 2021 · External reference
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer
10.1172/jci.insight.154646 · 2022 · External reference
Trib1 regulates T cell differentiation during chronic infection by restraining the effector program
2020 · External reference
PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation
10.1172/jci96107 · 2018 · External reference
Immune functions encoded by the natural killer gene complex
10.1038/nri1055 · 2003 · External reference
Vis-à-vis in the NKC: genetically linked natural killer cell receptor/ligand pairs in the natural killer gene complex (NKC)
10.1159/000324112 · 2011 · External reference
An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma
10.1038/nbt.4302 · 2018 · External reference
E-cadherin Plays a Role in Hepatitis B Virus Entry Through Affecting Glycosylated Sodium-Taurocholate Cotransporting Polypeptide Distribution
10.3389/fcimb.2020.00074 · 2020 · External reference
An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics
10.1080/22221751.2020.1826361 · 2020 · External reference