Research graph
References from Surface plasmon resonance microscopy identifies glycan heterogeneity in pancreatic cancer cells that influences mucin-4 binding interactions. Local targets link to admitted publications; unresolved targets remain external evidence.
Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory
10.1007/s00232-015-9802-0 · 2015 · External reference
Membrane protein production and formulation for drug discovery
10.1016/j.tips.2021.05.006 · 2021 · External reference
Prediction of the human membrane proteome
10.1002/pmic.200900258 · 2010 · External reference
Live Cells versus Fixated Cells: Kinetic Measurements of Biomolecular Interactions with the LigandTracer Method and Surface Plasmon Resonance Microscopy
10.1021/acs.molpharmaceut.2c01047 · 2023 · External reference
Vertebrate protein glycosylation: Diversity, synthesis and function
10.1038/nrm3383 · 2012 · External reference
Glycomics and glycoproteomics of membrane proteins and cell-surface receptors: Present trends and future opportunities
10.1002/elps.201500552 · 2016 · External reference
Macrophage N-glycan processing inhibits antibody-dependent cellular phagocytosis
2023 · External reference
Inhibiting N‐glycan processing increases the antibody binding affinity and effector function of human natural killer cells
2023 · External reference
Unresolved reference
2017 · External reference
The sweet and sour of cancer: Glycans as novel therapeutic targets
10.1038/nrc1649 · 2005 · External reference
Protein Glycosylation in Cancer.
10.1146/annurev-pathol-012414-040438 · 2015 · External reference
The glycosylation landscape of pancreatic cancer (Review).
2019 · External reference
Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyltransferases-IVa Regulation.
2015 · External reference
I-branched carbohydrates as emerging effectors of malignant progression
10.1073/pnas.1900268116 · 2019 · External reference
Altered glycosylation in cancer: A promising target for biomarkers and therapeutics
1875 · External reference
Glycosylation Changes in Brain Cancer
10.1021/acschemneuro.7b00271 · 2018 · External reference
The role of N-glycans in colorectal cancer progression: Potential biomarkers and therapeutic applications
2016 · External reference
MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans
10.1016/j.canlet.2021.01.015 · 2021 · External reference
Systemic immune dysfunction in pancreatic cancer patients
10.1007/s00423-006-0140-7 · 2007 · External reference
The immune network in pancreatic cancer development and progression
10.1038/onc.2013.257 · 2014 · External reference
Analysis of MUC4 expression in human pancreatic cancer xenografts in immunodeficient mice
2014 · External reference
MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy
External reference
Mass spectrometry-based N-linked glycomic profiling as a means for tracking pancreatic cancer metastasis
10.1016/j.carres.2015.04.019 · 2015 · External reference
N-linked glycosylation profiling of pancreatic cancer serum using capillary liquid phase separation coupled with mass spectrometric analysis
10.1021/pr0604458 · 2007 · External reference
Structure, evolution, and biology of the MUC4 mucin
10.1096/fj.07-9673rev · 2008 · External reference
The role of membrane mucin MUC4 in breast cancer metastasis
10.1530/erc-21-0083 · 2022 · External reference
MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1
10.1093/carcin/bgs225 · 2012 · External reference
Inhibition of MUC4 Expression Suppresses Pancreatic Tumor Cell Growth and Metastasis
10.1158/0008-5472.can-03-2636 · 2004 · External reference
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
10.1186/s12943-015-0386-1 · 2015 · External reference
Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer
2011 · External reference
A Sweet Warning: Mucin-Type O-Glycans in Cancer.
10.3390/cells11223666 · 2022 · External reference
Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets
2015 · External reference
Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation.
10.1172/jci.insight.122475 · 2019 · External reference
Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma
2016 · External reference
The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
2020 · External reference
Removal of N-Linked Glycosylation Enhances PD-L1 Detection in Colon Cancer: Validation Research Based on Immunohistochemistry Analysis.
2021 · External reference
Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1
2019 · External reference
Fc γ receptor compositional heterogeneity: Considerations for immunotherapy development
10.1074/jbc.rev120.013168 · 2021 · External reference
N-Glycosylation can selectively block or foster different receptor–ligand binding modes.
10.1038/s41598-021-84569-z · 2021 · External reference
Fc γ receptor IIIa/CD16a processing correlates with the expression of glycan-related genes in human natural killer cells
10.1074/jbc.ra120.015516 · 2021 · External reference
CD16a with oligomannose-type N-glycans is the only “low-affinity” Fc γ receptor that binds the IgG crystallizable fragment with high affinity in vitro
10.1074/jbc.ra118.004998 · 2019 · External reference
The weaker-binding Fc γ receptor IIIa F158 allotype retains sensitivity to N-glycan composition and exhibits a destabilized antibody-binding interface
10.1016/j.jbc.2022.102329 · 2022 · External reference
Site-specific N-glycan Analysis of Antibody-binding Fc γ Receptors from Primary Human Monocytes
10.1074/mcp.ra119.001733 · 2020 · External reference
Multiple Variables at the Leukocyte Cell Surface Impact Fc γ Receptor-Dependent Mechanisms.
10.3389/fimmu.2019.00223 · 2019 · External reference
Cellular glycosylation affects Herceptin binding and sensitivity of breast cancer cells to doxorubicin and growth factors
10.1038/srep43006 · 2017 · External reference
MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells
10.1158/0008-5472.can-07-6041 · 2008 · External reference
The EGF domains of MUC4 oncomucin mediate HER2 binding affinity and promote pancreatic cancer cell tumorigenesis
10.3390/cancers13225746 · 2021 · External reference
MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells
10.1038/sj.bjc.6604517 · 2008 · External reference
In situ drug-receptor binding kinetics in single cells: A quantitative label-free study of anti-tumor drug resistance
2014 · External reference
Microfluidically Partitioned Dual Channels for Accurate Background Subtraction in Cellular Binding Studies by Surface Plasmon Resonance Microscopy
2022 · External reference
Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of CC motif chemokine receptor-like 2 (CCRL2) ligand binding function
2023 · External reference
pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic PotentialS
10.1124/jpet.122.001554 · 2023 · External reference
Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging
2020 · External reference
The three-dimensional structure of PNGase F, a glycosyl asparaginase from Flavobacterium meningosepticum
10.1016/s0969-2126(94)00108-1 · 1994 · External reference
Unresolved reference
External reference
Structure and biological roles of mucin-type O-glycans at the ocular surface
10.1016/s1542-0124(12)70213-6 · 2010 · External reference
Unresolved reference
2017 · External reference
Multiplexed surrogate analysis of glycotransferase activity in whole biospecimens
10.1021/ac3035579 · 2013 · External reference
The glycomic effect of N-acetylglucosaminyltransferase III overexpression in metastatic melanoma cells. GnT-III modifies highly branched N-glycans
10.1007/s10719-018-9814-y · 2018 · External reference
Lectins: An effective tool for screening of potential cancer biomarkers.
2017 · External reference
Structural basis of trimannoside recognition by concanavalin A
10.1074/jbc.271.2.972 · 1996 · External reference
Analyzing the topology of N-linked glycans by PNGase F accessibility assay.
10.1016/j.xpro.2023.102458 · 2023 · External reference
Frontal affinity chromatography of ovalbumin glycoasparagines on a concanavalin A-Sepharose column. A quantitative study of the binding specificity of the lectin
10.1016/s0021-9258(18)88862-7 · 1985 · External reference
Oxidized dextran facilitated synthesis of a silica-based concanavalin a material for lectin affinity enrichment of glycoproteins/glycopeptides
2016 · External reference
Unresolved reference
2022 · External reference
Inflammation-induced changes in expression and glycosylation of genetic variants of α1-acid glycoprotein: Studies with human sera, primary cultures of human hepatocytes and transgenic mice
10.1042/bj2760343 · 1991 · External reference
10.1007/978-1-4615-1885-3_26
10.1007/978-1-4615-1885-3_26 · 1995 · External reference
Affinity Electrophoresis for Studies of Mechanisms Regulating Glycosylation of Plasma Proteins
10.1002/elps.1150101206 · 1989 · External reference
Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas
2017 · External reference
Helix pomatia agglutinin lectin-binding oligosaccharides of aggressive breast cancer
2001 · External reference
The involvement of Helix pomatia lectin (HPA) binding N-acetylgalactosamine glycans in cancer progression
2000 · External reference
The lectin Helix pomatia agglutinin recognizes O-GlcNAc containing glycoproteins in human breast cancer
10.1093/glycob/cws051 · 2012 · External reference
N-linked glycan release efficiency: A quantitative comparison between NaOCL and PNGase F release protocols
2019 · External reference
Unresolved reference
2022 · External reference
Tn epitope (N-acetyl-D-galactosamine alpha-O-serine/threonine) density in primary breast carcinoma: a functional predictor of aggressiveness
10.1016/0161-5890(89)90013-8 · 1989 · External reference
A suspension-cell biosensor for real-time determination of binding kinetics of protein-carbohydrate interactions on cancer cell surfaces
2013 · External reference
Label-free cell-based assay for characterization of biomolecules and receptors
10.1007/978-1-4939-7841-0_4 · 2018 · External reference
A novel approach to determining the affinity of protein-carbohydrate interactions employing adherent cancer cells grown on a biosensor surface
10.1016/j.bios.2012.02.037 · 2012 · External reference
Real-time and label-free analysis of binding thermodynamics of carbohydrate-protein interactions on unfxed cancer cell surfaces using a QCM biosensor
10.1038/srep14066 · 2015 · External reference
) Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent.
10.1080/19420862.2020.1792673 · 2020 · External reference
Real-time characterization of antibody binding to receptors on living immune cells
10.3389/fimmu.2017.00455 · 2017 · External reference
Targeting Aberrant Sialylation to Treat Cancer.
10.3390/medicines6040102 · 2019 · External reference
Unresolved reference
External reference
Hypersialylation in cancer: Modulation of inflammation and therapeutic opportunities
10.3390/cancers10060207 · 2018 · External reference
Editorial: Glycosylation changes in cancer: An innovative frontier at the interface of cancer and glycobiology
2016 · External reference
Unresolved reference
2015 · External reference
Unresolved reference
2017 · External reference
Glycans as cancer biomarkers
10.1016/j.bbagen.2011.12.001 · 2012 · External reference
Hallmarks of glycosylation in cancer
10.18632/oncotarget.8155 · 2016 · External reference
Targeting Glycosylation: A New Road for Cancer Drug Discovery
10.1016/j.trecan.2020.04.002 · 2020 · External reference
Oxidized-Desialylated Low-Density Lipoprotein Inhibits the Antitumor Functions of Lymphokine Activated Killer Cells
10.7150/jca.55526 · 2021 · External reference
