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References from Metabolomics and transcriptomics reveal the mechanism of alkaloid synthesis in Corydalis yanhusuo bulbs. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2020 · External reference
Research Progress on Chemical Components and Pharmacological Effects of Corydalis yanhusuo
2018 · External reference
Alkaloid constituents in Corydalis yanhusuo
2009 · External reference
Fingerprint-efficacy study of the quaternary alkaloids in Corydalis yanhusuo
10.1016/j.jep.2017.06.036 · 2017 · External reference
Alkaloid profiling of the traditional Chinese medicine Rhizoma corydalis using high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry
10.1016/j.apsb.2014.04.003 · 2014 · External reference
An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1
10.1016/j.foodchem.2012.09.059 · 2013 · External reference
Preparative isolation and purification of alkaloids from Corydalis yanhusuo W. T. Wang by High Speed Counter-Current Chromatography
10.1080/10826070500274638 · 2005 · External reference
Two new quaternary protoberberine alkaloids from Corydalis yanhusuo
10.1080/10286020.2012.677038 · 2012 · External reference
Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC-MS/MS and LC-DAD
10.1016/j.jpba.2007.06.009 · 2007 · External reference
Development and validation of a HPLC-ESI-MS/MS method for simultaneous quantification of fourteen alkaloids in mouse plasma after oral administration of the extract of Corydalis yanhusuo tuber: application to pharmacokinetic study
10.3390/molecules23040714 · 2018 · External reference
l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats
10.1371/journal.pone.0038627 · 2012 · External reference
Advances in studies on chemistry, pharmacology, and quality control of Corydalis yanhusuo
2007 · External reference
l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction
10.4155/fmc.11.166 · 2012 · External reference
Studies on Chemical Constituents of Corydalis yanhusuo
2012 · External reference
Antinociceptive effects of the extracts of Xylopia parviflora bark and its alkaloidal components in experimental animals
10.1007/s11418-009-0356-2 · 2010 · External reference
Constituents of Corydalis species. VI. Alkaloids from Chinese Corydalis and the identity of d-corydalmine with d-corybulbine
10.1021/jo01261a086 · 1969 · External reference
The Pharmacokinetics Study of Sanguinarine in Broiler using HPLC-MS/MS
2015 · External reference
The Antinociceptive Properties of the Corydalis yanhusuo Extract
10.1371/journal.pone.0162875 · 2016 · External reference
Efficient -liquid chromatography separation of tertiary and quaternary alkaloins from Rhizoma Corydalie and antagonistic activity test
2020 · External reference
Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world
10.1093/pcp/pct020 · 2013 · External reference
Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo
10.1038/s41438-020-00450-6 · 2021 · External reference
Benzylisoquinoline alkaloid biosynthesis in opium poppy
10.1007/s00425-014-2056-8 · 2014 · External reference
Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis
10.1038/s41467-023-42253-y · 2023 · External reference
Haplotype resolved gene assembly of Corydalis yanhusuo, a traditional Chinese medicine with unusual Telemere motif
2024 · External reference
Chapter 6-Biotechnological application of health promising bioactive molecules
2020 · External reference
Transcriptome repository of North-Western Himalayan endangered medicinal herbs: a paramount approach illuminating molecular perspective of phytoactive molecules and secondary metabolism
10.1007/s00438-021-01821-x · 2021 · External reference
DNA barcoding in herbal medicine: Retrospective and prospective
10.1016/j.jpha.2023.03.008 · 2023 · External reference
Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species
10.1016/b978-0-12-394290-6.00011-2 · 2012 · External reference
Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures
10.1186/1471-2229-10-252 · 2010 · External reference
Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy
2015 · External reference
Identification and developmental expression profiling of putative alkaloid biosynthetic genes in Corydalis yanhusuo bulbs
10.1038/srep19460 · 2016 · External reference
Signature-discovery approach for sample matching of a nerve-agent precursor using liquid chromatography-mass spectrometry, XCMS, and chemometrics
10.1021/ac1003568 · 2010 · External reference
Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses
10.1021/acs.jproteome.5b00354 · 2015 · External reference
KEGG: Kyoto Encyclopedia of Genes and Genomes
10.1093/nar/28.1.27 · 2000 · External reference
Fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · 2018 · External reference
Full-length transcriptome assembly from RNA-Seq data without a reference genome
10.1038/nbt.1883 · 2011 · External reference
Corset: enabling differential gene expression analysis for de novo assembled transcriptomes
2014 · External reference
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
10.1186/1471-2105-12-323 · 2011 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
SARTools: a DESeq2- and EdgeR-based R pipeline for comprehensive differential analysis of RNA-Seq data
10.1371/journal.pone.0157022 · 2016 · External reference
A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics
10.1093/mp/sst080 · 2013 · External reference
Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects
10.1016/j.bmc.2008.02.015 · 2008 · External reference
Rapid determination of seven bioactive components in rat plasma by UPLC-MS/MS and its application to pharmacokinetic compatibility study of Jinlingzi San
10.1016/j.jpba.2021.114014 · 2021 · External reference
Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids
10.1021/jo201056f · 2011 · External reference
Quaternary alkaloids of Argemone mexicana
10.3109/13880200903062622 · 2010 · External reference
Metabolic diversification of benzylisoquinoline alkaloid biosynthesis through the introduction of a branch pathway in Eschscholzia californica
10.1093/pcp/pcq063 · 2010 · External reference
Cheilanthifoline
10.1107/s1600536805039711 · 2005 · External reference
Studies on the metabolism and toxicological detection of glaucine, an isoquinoline alkaloid from Glaucium flavum (Papaveraceae), in rat urine using GC-MS, LC-MS(n) and LC-high-resolution MS(n)
10.1002/jms.3112 · 2013 · External reference
Analytical methods for determination of magnoflorine and saponins from roots of Caulophyllum thalictroides (L.) Michx. using UPLC, HPLC and HPTLC
10.1016/j.jpba.2011.07.028 · 2011 · External reference
Alkaloids profiling and acetylcholinesterase cholinesterase inhibitory activity of Corydalis species
2020 · External reference
Thaliporphine, an alkaloid from Neolitsea konishii, exerts antioxidant, anti-inflammatory, and anti-apoptotic responses in guinea pig during cardiovascular collapse in inflammatory disease
10.1016/j.jff.2016.07.002 · 2016 · External reference
Minor alkaloids from Guatteria dumetorum with antileishmanial activity
10.1055/s-2005-916179 · 2006 · External reference
Chemical constituents from Dehaasia triandra. 1. three new alkaloids, isocorydione, norisocorydione, and dehatriphine, from the Leaves
1996 · External reference
Isoquinoline alkaloids from Thalictrum delavayi
10.1055/s-2001-11518 · 2001 · External reference
Identification and characterization of genes involved in benzylisoquinoline alkaloid biosynthesis in Coptis Species
10.3389/fpls.2018.00731 · 2018 · External reference
Analysis of alkaloids in Macleaya cordata (Willd.) R. Br. using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry
10.1016/j.chroma.2008.08.066 · 2009 · External reference
Comparative qualitative and quantitative determination of alkaloids in narcotic and condiment Papaver somniferum cultivars
10.1021/np0496643 · 2005 · External reference
Sanguinarine biosynthesis is associated with the endoplasmic reticulum in cultured opium poppy cells after elicitor treatment
10.1104/pp.105.059287 · 2005 · External reference
Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis
10.1105/tpc.104.028654 · 2005 · External reference
Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy
10.1104/pp.112.194886 · 2012 · External reference
Noscapine comes of age
10.1016/j.phytochem.2014.09.008 · 2015 · External reference
Short-chain dehydrogenase/reductase catalyzing the final step of noscapine biosynthesis is localized to laticifers in opium poppy
10.1111/tpj.12379 · 2014 · External reference
Genes controlling expression of defense responses in Arabidopsis -2001 status
2001 · External reference
Research on the accumulation dynamic of dry matter and two alkaloids in the tubers of Corydalis yanhusuo
2010 · External reference
S-Adenosyl-L-methionine: Columbamine-O-methyl transferase, a compartmentalized enzyme in protoberberine biosynthesis
10.1007/bf00269113 · 1986 · External reference
Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells
10.1046/j.1432-1033.2002.03275.x · 2002 · External reference
Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells
10.1074/jbc.m705082200 · 2008 · External reference
Evolution of morphine biosynthesis in opium poppy
10.1016/j.phytochem.2009.07.006 · 2009 · External reference
Morphine biosynthesis in opium poppy involves two cell types: sieve elements and laticifers
10.1105/tpc.113.115113 · 2013 · External reference
Impact of various factors responsible for fluctuation in plant secondary metabolites
10.1016/j.jarmap.2015.09.002 · 2015 · External reference
Effect on quality and yield of Coptis chinensis with its different age and month at different altitude
2002 · External reference