Research graph
References from Genome wide association study of clinical duration and age at onset of sporadic CJD. Local targets link to admitted publications; unresolved targets remain external evidence.
Intensity of human prion disease surveillance predicts observed disease incidence
10.1136/jnnp-2012-304820 · 2013 · External reference
Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies
10.1093/brain/awh249 · 2004 · External reference
The Medical Research Council prion disease rating scale: a new outcome measure for prion disease therapeutic trials developed and validated using systematic observational studies
10.1093/brain/awt048 · 2013 · External reference
Development of novel clinical examination scales for the measurement of disease severity in Creutzfeldt-Jakob disease
10.1136/jnnp-2021-327722 · 2022 · External reference
Sporadic Creutzfeldt-Jakob Disease in the young (50 and below): 10-year review of United Kingdom surveillance.
10.1007/s00415-022-11467-3 · 2023 · External reference
Sporadic Creutzfeldt-Jakob Disease in a Very Young Person
10.1212/wnl.0000000000012737 · 2021 · External reference
Unresolved reference
2021 · External reference
Development of Prognostic Models for Survival and Care Status in Sporadic Creutzfeldt-Jakob disease
10.1093/braincomms/fcac201 · 2022 · External reference
Novel proteinaceous infectious particles cause scrapie
10.1126/science.6801762 · 1982 · External reference
High-resolution structure and strain comparison of infectious mammalian prions
10.1016/j.molcel.2021.08.011 · 2021 · External reference
2.7 A cryo-EM structure of ex vivo RML prion fibrils
10.1038/s41467-022-30457-7 · 2022 · External reference
NMR structure of the mouse prion protein domain PrP(121–231).
10.1038/382180a0 · 1996 · External reference
Contribution of transgenic models to understanding human prion disease.
10.1111/j.1365-2990.2010.01129.x · 2010 · External reference
A structural basis for prion strain diversity
10.1038/s41589-022-01229-7 · 2023 · External reference
Mechanisms of prion-induced toxicity
10.1007/s00441-022-03683-0 · 2023 · External reference
Loss of PIKfyve drives the spongiform degeneration in prion diseases
10.15252/emmm.202114714 · 2021 · External reference
Sustained translational repression by eIF2 alpha-P mediates prion neurodegeneration
10.1038/nature11058 · 2012 · External reference
A prognostic model for overall survival in sporadic Creutzfeldt-Jakob disease.
10.1002/alz.12133 · 2020 · External reference
Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study
10.1016/s1474-4422(20)30273-8 · 2020 · External reference
Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease
10.1016/s1474-4422(20)30477-4 · 2021 · External reference
Evaluation of the impact of CSF prion RT-QuIC and amended criteria on the clinical diagnosis of Creutzfeldt-Jakob disease: a 10-year study in Italy.
10.1136/jnnp-2022-330153 · 2023 · External reference
Next-generation genotype imputation service and methods
10.1038/ng.3656 · 2016 · External reference
LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies
10.1038/ng.3211 · 2015 · External reference
Functional mapping and annotation of genetic associations with FUMA.
10.1038/s41467-017-01261-5 · 2017 · External reference
MAGMA: generalized gene-set analysis of GWAS data.
10.1371/journal.pcbi.1004219 · 2015 · External reference
An analysis of transformations.
10.1111/j.2517-6161.1964.tb00553.x · 1964 · External reference
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer abeta oligomer bound to cellular prion protein
10.1016/j.neuron.2013.06.036 · 2013 · External reference
Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease
10.1093/brain/awv356 · 2015 · External reference
Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs
10.1083/jcb.201308028 · 2014 · External reference
Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseases
10.1099/vir.0.82286-0 · 2007 · External reference
Mice devoid of PrP are resistant to scrapie
10.1016/0092-8674(93)90360-3 · 1993 · External reference
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis
10.1126/science.1090187 · 2003 · External reference
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
10.1073/pnas.0802759105 · 2008 · External reference
Antisense oligonucleotides extend survival of prion-infected mice.
10.1172/jci.insight.131175 · 2019 · External reference
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
10.1093/nar/gkaa616 · 2020 · External reference
A single-cell map of antisense oligonucleotide activity in the brain
10.1093/nar/gkad371 · 2023 · External reference
Age at onset of genetic (E200K) and sporadic Creutzfeldt-Jakob diseases is modulated by the CYP4X1 gene.
10.1136/jnnp-2018-318756 · 2018 · External reference
Identification of novel genes for age-at-onset of Alzheimer’s disease by combining quantitative and survival trait analyses.
10.1002/alz.12927 · 2023 · External reference
Parkinson’s disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms
10.1002/mds.27659 · 2019 · External reference
The importance of ongoing international surveillance for Creutzfeldt-Jakob disease.
10.1038/s41582-021-00488-7 · 2021 · External reference
