Research graph
References from Polyamines (PAs) but not small peptides with closely spaced positively charged groups interact with DNA and RNA, but they do not represent a relevant buffer system at physiological pH values. Local targets link to admitted publications; unresolved targets remain external evidence.
Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell
10.1016/j.jmb.2015.06.020 · 2015 · External reference
Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma
10.1126/sciadv.abc8929 · 2021 · External reference
pH regulates hematopoietic stem cell potential via polyamines
10.15252/embr.202255373 · 2023 · External reference
Stable intracellular acidification upon polyamine depletion induced by α-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells
10.1042/bj3120749 · 1995 · External reference
Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines
10.1126/science.7754371 · 1995 · External reference
Polyamine-dependent gene expression
10.1007/s00018-003-2332-4 · 2003 · External reference
Polyamines interact with DNA as molecular aggregates
10.1046/j.1432-1033.2002.03128.x · 2002 · External reference
Pattern preferences of DNA nucleotide motifs by polyamines putrescine2+, spermidine3+ and spermine4+
10.1093/nar/gkz434 · 2019 · External reference
Regulation of intracellular pH in eukaryotic cells
10.1042/bj2500001 · 1988 · External reference
Intracellular pH regulation by acid-base transporters in mammalian neurons
10.3389/fphys.2014.00043 · 2014 · External reference
Unresolved reference
External reference
Determination of pKa values and total proton distribution pattern of spermidine by carbon-13 nuclear magnetic resonance titrations
10.1021/ac00229a011 · 1981 · External reference
Complex formation between 4, 9-diazadodecane-1, 12-diamine (spermine) and copper (II) ions and protons in aqueous solution
10.1039/dt9740002086 · 1974 · External reference
Dissociation Constants of Peptides. I. A Survey of the Effect of Optical Configuration1
10.1021/ja01140a065 · 1952 · External reference
Interaction between polyamines and nucleic acids or phospholipids
10.1016/0003-9861(82)90175-8 · 1982 · External reference
Endogenous polyamine function—the RNA perspective
10.1093/nar/gku837 · 2014 · External reference
Spermine Condenses DNA, but Not RNA Duplexes
10.1016/j.bpj.2016.11.018 · 2017 · External reference
Polyamine induced Z-conformation of native calf thymus DNA
10.1016/0014-5793(95)00591-v · 1995 · External reference
Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation
10.1016/0304-4157(89)90004-x · 1989 · External reference
Role of chloride/bicarbonate antiport in the control of cytosolic pH. Cell-line differences in activity and regulation of antiport
10.1016/s0021-9258(18)37930-4 · 1988 · External reference
Brain H+/CO2 sensing and control by glial cells
10.1002/glia.24152 · 2022 · External reference
Astrocytes Control Breathing Through pH-Dependent Release of ATP
10.1126/science.1190721 · 2010 · External reference
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
10.1038/s41467-020-18756-3 · 2020 · External reference
Macromolecular crowding: obvious but underappreciated
10.1016/s0968-0004(01)01938-7 · 2001 · External reference
Cellular concentrations of enzymes and their substrates
10.1016/s0022-5193(05)80266-8 · 1990 · External reference
Proteome-pI 2.0: proteome isoelectric point database update
10.1093/nar/gkab944 · 2021 · External reference
Unique Chemistry, Intake, and Metabolism of Polyamines in the Central Nervous System (CNS) and Its Body
10.3390/biom12040501 · 2022 · External reference
Modulation of pH by neuronal activity
10.1016/0166-2236(92)90191-a · 1992 · External reference
Regulation and Modulation of pH in the Brain
10.1152/physrev.00010.2003 · 2003 · External reference
Structure and mechanism of the human NHE1-CHP1 complex
10.1038/s41467-021-23496-z · 2021 · External reference
Structure and Function of SLC4 Family HCO3- Transporters
2015 · External reference
Physiological Functions and Regulation of the Na+/H+ Exchanger [NHE1] in Renal Tubule Epithelial Cells
10.1159/000368521 · 2015 · External reference
