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References from hnRNP Q/SYNCRIP interacts with LIN28B and modulates the LIN28B/let-7 axis in human hepatoma cells. Local targets link to admitted publications; unresolved targets remain external evidence.
A census of human RNA-binding proteins
10.1038/nrg3813 · 2014 · External reference
A brave new world of RNA-binding proteins
10.1038/nrm.2017.130 · 2018 · External reference
RNA-binding proteins: modular design for efficient function
10.1038/nrm2178 · 2007 · External reference
RNA-Binding Proteins in Cancer: Functional and Therapeutic Perspectives.
10.3390/cancers12092699 · 2020 · External reference
MicroRNA regulation by RNA-binding proteins and its implications for cancer
10.1038/nrc3107 · 2011 · External reference
RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment.
10.15430/jcp.2017.22.4.203 · 2017 · External reference
RNA-binding proteins in human genetic disease
10.1038/s41576-020-00302-y · 2021 · External reference
The regulatory impact of RNA-binding proteins on microRNA targeting
10.1038/s41467-021-25078-5 · 2021 · External reference
The Lin28 cold-shock domain remodels pre-let-7 microRNA
10.1093/nar/gks355 · 2012 · External reference
Selective blockade of microRNA processing by Lin28
10.1126/science.1154040 · 2008 · External reference
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans.
10.1038/nsmb.1675 · 2009 · External reference
LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans
10.1038/nsmb.1986 · 2011 · External reference
Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma.
10.1016/j.gene.2006.07.011 · 2006 · External reference
Lin28: A microRNA regulator with a macro role
10.1016/j.cell.2010.02.007 · 2010 · External reference
Lin28 promotes transformation and is associated with advanced human malignancies
10.1038/ng.392 · 2009 · External reference
Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer
10.1038/onc.2009.500 · 2010 · External reference
H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance
10.1038/cddis.2016.438 · 2017 · External reference
The LIN28/let-7 Pathway in Cancer.
10.3389/fgene.2017.00031 · 2017 · External reference
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA
10.1016/j.molcel.2008.09.014 · 2008 · External reference
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
10.1038/nsmb.1676 · 2009 · External reference
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms
10.1016/j.cell.2011.10.039 · 2011 · External reference
Processing of primary microRNAs by the Microprocessor complex
10.1038/nature03049 · 2004 · External reference
The Microprocessor complex mediates the genesis of microRNAs
10.1038/nature03120 · 2004 · External reference
Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition
10.1261/rna.036491.112 · 2013 · External reference
Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells
10.1016/j.celrep.2021.109198 · 2021 · External reference
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
10.1038/ncb1759 · 2008 · External reference
The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms
2021 · External reference
Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs.
10.7554/elife.66288 · 2021 · External reference
Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites
10.1016/s0012-1606(03)00126-x · 2003 · External reference
Localization of the Developmental Timing Regulator Lin28 to mRNP Complexes, P-bodies and Stress Granules
10.4161/rna.4.1.4364 · 2007 · External reference
LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro
10.1242/dev.042895 · 2010 · External reference
Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency
10.1101/gad.415007 · 2007 · External reference
Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells
10.1261/rna.1368009 · 2009 · External reference
Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
10.1093/nar/gkp1071 · 2010 · External reference
LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
10.1016/j.molcel.2012.08.004 · 2012 · External reference
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
10.4161/rna.25194 · 2013 · External reference
LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.
10.1016/j.stem.2016.05.009 · 2016 · External reference
Identification of RNA-binding proteins that partner with Lin28a to regulate Dnmt3a expression.
10.1038/s41598-021-81429-8 · 2021 · External reference
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells
10.1038/ng.3854 · 2017 · External reference
SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells.
10.3390/ijms23020913 · 2022 · External reference
Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer
10.1038/cddis.2016.479 · 2018 · External reference
The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene.
10.1128/mcb.01332-08 · 2008 · External reference
Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression
10.1016/j.molcel.2009.02.010 · 2009 · External reference
Systematic Analysis of Gene Expression Profiles Controlled by hnRNP Q and hnRNP R, Two Closely Related Human RNA Binding Proteins Implicated in mRNA Processing Mechanisms.
2018 · External reference
SYNCRIP, a new player in pri-let-7a processing
10.1261/rna.072959.119 · 2020 · External reference
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
10.1002/path.4130 · 2013 · External reference
LIN28B-AS1-IGF2BP1 binding promotes hepatocellular carcinoma cell progression. Cell Death &
2020 · External reference
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis
10.1038/nsmb.1874 · 2010 · External reference
A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis
10.1016/j.molcel.2017.03.014 · 2017 · External reference
LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells
10.1128/mcb.00426-15 · 2015 · External reference
Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.
10.1371/journal.pbio.1001564 · 2013 · External reference
Widespread microRNA repression by Myc contributes to tumorigenesis
10.1038/ng.2007.30 · 2008 · External reference
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
10.1073/pnas.0808300106 · 2009 · External reference
