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References from A PLA2 deletion mutant using CRISPR/Cas9 coupled to RNASeq reveals insect immune genes associated with eicosanoid signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Eicosanoids in inflammation in the blood and the vessel
10.3389/fphar.2022.997403 · 2022 · External reference
Unresolved reference
2000 · External reference
Prostaglandins in non-insectan invertebrates: recent insights and unsolved problems
10.1242/jeb.01275 · 2005 · External reference
10.1042/ebc20190083
10.1042/ebc20190083 · 2020 · External reference
Polyunsaturated fatty acids and fatty acid-derived lipid mediators: recent advances in the understanding of their biosynthesis, structures, and functions
10.1016/j.plipres.2022.101165 · 2022 · External reference
Allosteric regulation by membranes and hydrophobic subsites in phospholipase A2 enzymes determine their substrate specificity
10.1016/j.jbc.2022.101873 · 2022 · External reference
Identification of four secretory phospholipase A2s in a lepidopteran insect, Acrolepiopsis sapporensis, and their functional association with cellular immune responses.
10.3389/fendo.2023.1190834 · 2023 · External reference
Why most insects have very low proportions of C20 polyunsaturated fatty acids: the oxidative damage hypothesis
10.1002/arch.21622 · 2020 · External reference
Biosynthetic pathway of arachidonic acid in Spodoptera exigua in response to bacterial challenge
10.1016/j.ibmb.2019.103179 · 2019 · External reference
Direct evidence of the cyclooxygenase pathway of prostaglandin synthesis in arthropods: genetic and biochemical characterization of two crustacean cyclooxygenases
10.1016/j.ibmb.2009.10.002 · 2009 · External reference
Drosophila pxt: a cyclooxygenase-like facilitator of follicle maturation
10.1242/dev.017590 · 2008 · External reference
Roles of peroxinectin in PGE2-mediated cellular immunity in Spodoptera exigua
10.1371/journal.pone.0105717 · 2014 · External reference
An insect prostaglandin E2 synthase acts in immunity and reproduction
10.3389/fphys.2018.01231 · 2018 · External reference
The first report of prostacyclin and its physiological roles in insects
10.1016/j.ygcen.2020.113659 · 2020 · External reference
Prostaglandin D2 synthase and its functional association with immune and reproductive processes in a lepidopteran insect, Spodoptera exigua
10.1016/j.ygcen.2019.113352 · 2020 · External reference
Double peroxidase and histone acetyltransferase AgTip60 maintain innate immune memory in primed mosquitoes
10.1073/pnas.2114242118 · 2021 · External reference
Biosynthesis and immunity of epoxyeicosatrienoic acids in a lepidopteran insect, Spodoptera exigua
10.1016/j.dci.2020.103643 · 2020 · External reference
Phospholipase A2 structure/function, mechanism, and signaling
10.1194/jlr.r800033-jlr200 · 2009 · External reference
The non-venom insect phospholipases A2
10.1016/j.bbalip.2006.05.011 · 2006 · External reference
Review of four major distinct types of human phospholipase A2.
10.1016/j.jbior.2017.10.009 · 2018 · External reference
The phospholipase A2 superfamily and its group numbering system
10.1016/j.bbalip.2006.07.011 · 2006 · External reference
Eicosanoid-mediated immunity in insects
10.1016/j.dci.2017.12.005 · 2018 · External reference
High-level expression in Escherichia coli and rapid purification of enzymatically active honey bee venom phospholipase A2
10.1016/0005-2760(92)90188-2 · 1992 · External reference
Molecular characterization of a gene encoding the Drosophila melanogaster phospholipase A2
10.1016/s0167-4781(03)00143-x · 2003 · External reference
Genes encoding phospholipases A2 mediate insect nodulation reactions to bacterial challenge
10.1016/j.jinsphys.2009.11.008 · 2010 · External reference
A phospholipase A2 gene is linked to Jack bean urease toxicity in the Chagas’ disease vector Rhodnius prolixus
10.1016/j.bbagen.2013.09.016 · 2014 · External reference
Lipid mediators and vector infection: Trypanosoma rangeli inhibits Rhodnius prolixus hemocyte phagocytosis by modulation of phospholipase A2 and PAF-acetylhydrolase activities
10.1016/j.jinsphys.2008.08.013 · 2008 · External reference
A non-venomous sPLA2 of a lepidopteran insect: its physiological functions in development and immunity
10.1016/j.dci.2018.08.008 · 2018 · External reference
Secretion of secretory phospholipase A2 into Spodoptera exigua larval midgut lumen and its role in lipid digestion
10.1111/imb.12588 · 2019 · External reference
Drosoophila innate immunity involves multiple signaling pathways and coordinated communication between different tissues
10.3389/fimmu.2022.905370 · 2022 · External reference
Biological mediators of insect immunity
10.1146/annurev.ento.42.1.611 · 1997 · External reference
Rac1 mediates cytokine-stimulated hemocyte spreading via prostaglandin biosynthesis in the beet armyworm, Spodoptera exigua
10.1016/j.jinsphys.2013.04.012 · 2013 · External reference
Eicosanoids mediate insect hemocyte migration
10.1016/j.jinsphys.2007.09.004 · 2008 · External reference
Insect hemocytes and their role in immunity
10.1016/s0965-1748(02)00092-9 · 2002 · External reference
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
10.1038/nature735 · 2002 · External reference
PGE2 mediates hemocyte-spreading behavior by activating aquaporin via cAMP and rearranging actin cytoskeleton via Ca2+
10.1016/j.dci.2021.104230 · 2021 · External reference
Eicosanoid mediates prophenoloxidase release from oenocytoids in the beet armyworm, Spodoptera exigua
10.1016/j.ibmb.2007.09.013 · 2008 · External reference
Eicosanoids up-regulate production of reactive oxygen species by NADPH-dependent oxidase in Spodoptera exigua phagocytic hemocytes
10.1016/j.jinsphys.2015.06.005 · 2015 · External reference
A newly established in vitro culture using transgenic Drosophila reveals functional coupling between the phospholipase A2-generated fatty acid cascade and lipopolysaccharide-dependent activation of the immune deficiency (imd) pathway in insect immunity.
10.1042/bj20021603 · 2003 · External reference
Oenocytoid cell lysis to release prophenoloxidase is induced by eicosanoid via protein kinase C
10.1016/j.aspen.2009.08.001 · 2009 · External reference
Hemocytes of Ciona intestinalis express multiple genes involved in innate immune host defense
10.1016/s0006-291x(03)00113-x · 2003 · External reference
Two groups of entomopathogenic bacteria, Photorhabdus and Xenorhabdus, share an inhibitory action against phospholipase A2 to induce host immuno depression
2005 · External reference
Immunosuppressive activities of novel PLA2 inhibitors from Xenorhabdus hominickii, an entomopathogenic bacterium.
10.3390/insects11080505 · 2020 · External reference
Identification of immunity-related genes in Plutella xylostella in response to fungal peptide destruxin A: RNA-Seq and DGE analysis.
10.1038/s41598-017-11298-7 · 2017 · External reference
Transcriptomic analysis of the interactions between the Spodoptera exigua midgut and nucleopolyhedrovirus
10.1016/j.pestbp.2019.11.020 · 2020 · External reference
Simple mass-rearing of beet armyworm, Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae), on an artificial diet.
1990 · External reference
Eicosanoids rescue Spodoptera exigua infected with Xenorhabdus nematophilus, the symbiotic bacteria to the entomopathogenic nematode Steinernema carpocapsae
10.1016/s0022-1910(00)00071-8 · 2000 · External reference
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
10.1373/clinchem.2008.112797 · 2009 · External reference
Analysis of relative gene expression data analysis using real-time quantitative PCR and the 2-ΔΔCT method.
10.1006/meth.2001.1262 · 2001 · External reference
A prophylactic role of a secretory PLA2 of Spodoptera exigua against entomopathogens
10.1016/j.dci.2019.02.008 · 2019 · External reference
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye finding
10.1016/0003-2697(76)90527-3 · 1972 · External reference
Efficient isolation method for high-quality genomic DNA from cicada exuviae
10.1002/ece3.3398 · 2017 · External reference
Unresolved reference
1989 · External reference
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
10.1126/science.1225829 · 2012 · External reference
Insert, remove or replace: a highly advanced genome editing system using CRISPR/Cas9
10.1016/j.bbamcr.2016.06.009 · 2016 · External reference
Progress and prospects of CRISPR/Cas systems in insects and other arthropods
10.3389/fphys.2017.00608 · 2017 · External reference
An entomopathogenic bacterium, Xenorhabdus nematophila, suppresses expression of antimicrobial peptides controlled by Toll and Imd pathways by blocking eicosanoid biosynthesis
10.1002/arch.21103 · 2013 · External reference
comprehensive analysis of the Manduca sexta immunotranscriptome
10.1016/j.dci.2012.10.004 · 2013 · External reference
A novel calcium-independent cellular PLA2 acts in insect immunity and larval growth
10.1016/j.ibmb.2015.09.012 · 2015 · External reference
A novel calcium-independent phospholipase A2 and its physiological roles in development and immunity of a lepidopteran insect, Spodoptera exigua
10.1016/j.dci.2017.08.014 · 2017 · External reference
Deletion mutant of PGE2 receptor using CRISPR-Cas9 exhibits larval immunosuppression and adult infertility in a lepidopteran insect, Spodoptera exigua
10.1016/j.dci.2020.103743 · 2020 · External reference
Repat33 acts as a downstream component of eicosanoid signaling pathway mediating immune responses of Spodoptera exigua, a lepidopteran insect.
10.3390/insects12050449 · 2021 · External reference
REPAT, a new family of proteins induced by bacterial toxins and baculovirus infection in Spodoptera exigua
10.1016/j.ibmb.2007.06.007 · 2007 · External reference
In vitro secretion of digestive phospholipase A2 by midguts isolated from tobacco hornworm, Manduca sexta
10.1002/(sici)1520-6327(199911)42:3<179::aid-arch2>3.0.co;2-r · 1999 · External reference
Three metabolites from an entomopathogenic bacterium, Xenorhabdus nematophila, inhibit larval development of Spodoptera exigua (Lepidoptera: Noctuidae) by inhibiting a digestive enzyme, phospholipase A2.
10.1111/j.1744-7917.2010.01363.x · 2011 · External reference
Digestion and absorption of lipids in insects.
10.1016/0300-9629(79)90171-3 · 1979 · External reference
Iatrou, K. Prostaglandin signaling and ovarian follicle development in the silkworm, Bombyx mori
10.1016/j.ibmb.2007.04.003 · 2007 · External reference
Drosophila eggshell production: identification of new genes and coordination by Pxt.
10.1371/journal.pone.0019943 · 2011 · External reference
Drosophila nonmuscle myosin II is required for rapid cytoplasmic transport during oogenesis and for axial nuclear migration in early embryos
10.1242/dev.121.6.1937 · 1995 · External reference
Inhibition of prostaglandin biosynthesis leads to suppressed ovarian development in Spodoptera exigua
10.1016/j.jinsphys.2019.03.002 · 2019 · External reference
