Research graph
References from TIR domains of TLR family-from the cell culture to the protein sample for structural studies. Local targets link to admitted publications; unresolved targets remain external evidence.
Toll-like Receptors and Innate Immunity
10.1038/35100529 · 2001 · External reference
Toll-like Receptor Signaling in Cell Proliferation and Survival
10.1016/j.cyto.2009.08.010 · 2010 · External reference
Pattern Recognition Receptors and Inflammation
10.1016/j.cell.2010.01.022 · 2010 · External reference
Toll-like Receptors and the Control of Immunity
10.1016/j.cell.2020.02.041 · 2020 · External reference
Toll-Like Receptors: General Molecular and Structural Biology
10.1155/2021/9914854 · 2021 · External reference
Toll-like Receptors in the Pathogenesis of Human Disease
10.1038/ni1116 · 2004 · External reference
Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems
10.3389/fimmu.2021.777606 · 2021 · External reference
Toll-like Receptors and Cancer
10.1038/nrc2541 · 2009 · External reference
Toll-like Receptor-Guided Therapeutic Intervention of Human Cancers: Molecular and Immunological Perspectives
10.3389/fimmu.2023.1244345 · 2023 · External reference
The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism
10.4049/jimmunol.1800085 · 2018 · External reference
Systemic Clinical Tumor Regressions and Potentiation of PD1 Blockade within Situ Vaccination
10.1038/s41591-019-0410-x · 2019 · External reference
Structural Basis of CpG and Inhibitory DNA Recognition by Toll-like Receptor 9
10.1038/nature14138 · 2015 · External reference
Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim
10.1021/acs.jmedchem.8b01583 · 2019 · External reference
Structural Basis of TLR5-Flagellin Recognition and Signaling
10.1126/science.1215584 · 2012 · External reference
The Structural Basis of Lipopolysaccharide Recognition by the TLR4–MD-2
2009 · External reference
Toll-like Receptor 8 Senses Degradation Products of Single-Stranded RNA
10.1038/nsmb.2943 · 2015 · External reference
Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
10.1016/j.cell.2007.09.008 · 2007 · External reference
Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer
10.1016/j.immuni.2009.09.018 · 2009 · External reference
The Architecture of Transmembrane and Cytoplasmic Juxtamembrane Regions of Toll-like Receptors
10.1038/s41467-023-37042-6 · 2023 · External reference
Spatial Structure of TLR4 Transmembrane Domain in Bicelles Provides the Insight into the Receptor Activation Mechanism
10.1038/s41598-017-07250-4 · 2017 · External reference
Cryo-EM Structures of Toll-like Receptors in Complex with UNC93B1
10.1038/s41594-020-00542-w · 2021 · External reference
Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR–TIR Interaction for Toll-Like Receptor Signaling Pathway
10.1016/j.jmb.2014.07.024 · 2014 · External reference
Structural Basis for Signal Transduction by the Toll/Interleukin-1 Receptor Domains
10.1038/35040600 · 2000 · External reference
The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer
10.1074/jbc.c800001200 · 2008 · External reference
Modulation of Toll-like Receptor 1 Intracellular Domain Structure and Activity by Zn2+ Ions
10.1038/s42003-021-02532-0 · 2021 · External reference
Preliminary X-Ray Crystallographic Studies of the TIR Domain of Human Toll-like Receptor 6
10.1107/s2053230x1401245x · 2014 · External reference
Sampling the Cultivation Parameter Space for the Bacterial Production of TLR1 Intracellular Domain Reveals the Multiple Optima
10.1016/j.pep.2021.105832 · 2021 · External reference
10.1007/978-1-59745-541-1_6
10.1007/978-1-59745-541-1_6 · 2009 · External reference
The Structure of Human Collapsin Response Mediator Protein 2, a Regulator of Axonal Growth
10.1111/j.1471-4159.2006.04401.x · 2007 · External reference
Isolation of Degrees of Freedom for Box—Behnken Designs
1994 · External reference
Optimization of Culture Conditions for the Expression of Three Different Insoluble Proteins in Escherichia Coli
10.1038/s41598-019-53200-7 · 2019 · External reference
Expression of Proteins in Escherichia Coli as Fusions with Maltose-Binding Protein to Rescue Non-Expressed Targets in a High-Throughput Protein-Expression and Purification Pipeline
10.1107/s1744309111022159 · 2011 · External reference
A Simple Method for Improving Protein Solubility and Long-Term Stability
10.1021/ja049297h · 2004 · External reference
Highly Accurate Protein Structure Prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
MyD88 TIR Domain Higher-Order Assembly Interactions Revealed by Microcrystal Electron Diffraction and Serial Femtosecond Crystallography
10.1038/s41467-021-22590-6 · 2021 · External reference
Structural Basis of TIR-Domain-Assembly Formation in MAL- and MyD88-Dependent TLR4 Signaling
10.1038/nsmb.3444 · 2017 · External reference
A Small Molecule Toll-like Receptor Antagonist Rescues α-Synuclein Fibril Pathology
10.1016/j.jbc.2022.102260 · 2022 · External reference
MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling
10.1016/j.str.2020.01.003 · 2020 · External reference
The Structural Biology of Toll-like Receptors
10.1016/j.str.2011.02.004 · 2011 · External reference
Structural Basis for the Multiple Interactions of the MyD88 TIR Domain in TLR4 Signaling
10.1073/pnas.0812956106 · 2009 · External reference
Crystal Structure of Toll-like Receptor Adaptor MAL/TIRAP Reveals the Molecular Basis for Signal Transduction and Disease Protection
10.1073/pnas.1104780108 · 2011 · External reference
The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway
10.1038/srep13128 · 2015 · External reference
Helical Assembly in the MyD88–IRAK4–IRAK2 Complex in TLR/IL-1R Signalling
10.1038/nature09121 · 2010 · External reference
Unresolved reference
2015 · External reference
Recovering Lost Magnetization: Polarization Enhancement in Biomolecular NMR
10.1007/s10858-010-9461-5 · 2011 · External reference
