Research graph
References from Prostaglandin D2 receptor 2 downstream signaling and modulation of type 2 innate lymphoid cells from patients with asthma. Local targets link to admitted publications; unresolved targets remain external evidence.
The Global Asthma Report 2022.
10.5588/ijtld.22.1010 · 2022 · External reference
Uncontrolled asthma: a review of the prevalence, disease burden and options for treatment.
10.1016/j.rmed.2006.03.031 · 2006 · External reference
New Targeted Therapies for Uncontrolled Asthma
10.1016/j.jaip.2019.03.022 · 2019 · External reference
Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia
10.1016/j.jaci.2015.05.037 · 2016 · External reference
Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients
10.1016/j.jaci.2019.01.027 · 2019 · External reference
Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives.
10.1007/s40265-017-0777-2 · 2017 · External reference
The prostaglandin D2 receptor 2 pathway in asthma: a key player in airway inflammation.
10.1186/s12931-018-0893-x · 2018 · External reference
Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes
10.1164/ajrccm/144.1.51 · 1991 · External reference
Elevated Prostaglandin D2 (PGD2) Levels in Bronchoalveolar Lavage Fluid (BALF) in Severe Asthma.
2010 · External reference
Targeting cell signaling in allergic asthma
10.1038/s41392-019-0079-0 · 2019 · External reference
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
10.1038/ni.2104 · 2011 · External reference
Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation
10.1016/j.jaci.2018.10.069 · 2019 · External reference
Emerging roles of DP and CRTH2 in allergic inflammation
10.1016/j.molmed.2006.02.005 · 2006 · External reference
Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
10.1084/jem.193.2.255 · 2001 · External reference
Prostaglandin D2 metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP2 receptor
10.1186/s12931-021-01852-3 · 2021 · External reference
Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils.
10.1111/j.1476-5381.2010.01086.x · 2011 · External reference
Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events
10.1183/09031936.00061614 · 2015 · External reference
Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction
10.1152/jappl.1989.66.4.1685 · 1989 · External reference
Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells.
10.1046/j.0019-2805.2001.01340.x · 2002 · External reference
Effects of a thromboxane receptor antagonist on prostaglandin D2 and histamine induced bronchoconstriction in man
10.1111/j.1365-2125.1994.tb04249.x · 1994 · External reference
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
10.1126/sciimmunol.aal5196 · 2017 · External reference
PPARγ enhances ILC2 function during allergic airway inflammation via transcription regulation of ST2.
10.1038/s41385-020-00339-6 · 2021 · External reference
PPAR and immune system—what do we know?
10.1016/s1567-5769(02)00057-7 · 2002 · External reference
Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation
10.4049/jimmunol.175.9.5744 · 2005 · External reference
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions.
10.1038/s41467-021-22764-2 · 2021 · External reference
The devil’s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33.
10.1038/s41385-020-00363-6 · 2021 · External reference
PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors
10.1016/j.bcp.2007.03.023 · 2007 · External reference
Antagonists of the prostaglandin D2 receptor CRTH2
10.1358/dnp.2008.21.6.1246831 · 2008 · External reference
9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2
10.1016/j.febslet.2005.11.052 · 2006 · External reference
15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma.
10.3389/fimmu.2017.00740 · 2017 · External reference
15d-PGJ2: the anti-inflammatory prostaglandin?
10.1016/j.clim.2004.09.008 · 2005 · External reference
Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2
10.1038/sj.bjp.0704973 · 2002 · External reference
CRTH2 antagonists in asthma: current perspectives
2017 · External reference
New treatments for asthma: From the pathogenic role of prostaglandin D2 to the therapeutic effects of fevipiprant
10.1016/j.phrs.2019.104490 · 2020 · External reference
Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial.
10.1016/s2213-2600(16)30179-5 · 2016 · External reference
DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.
2019 · External reference
Phase 3b randomized controlled trial of fevipiprant in patients with nasal polyposis with asthma (THUNDER).
10.1016/j.jaci.2021.12.759 · 2022 · External reference
Effectiveness of fevipiprant in reducing exacerbations in patients with severe asthma (LUSTER-1 and LUSTER-2): two phase 3 randomised controlled trials.
10.1016/s2213-2600(20)30412-4 · 2021 · External reference
Efficacy and safety of fevipiprant in patients with uncontrolled asthma: Two replicate, phase 3, randomised, double-blind, placebo-controlled trials (ZEAL-1 and ZEAL-2).
10.1016/j.eclinm.2021.100847 · 2021 · External reference
Fevipiprant, a selective prostaglandin D2 receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function
10.1016/j.jaci.2019.02.015 · 2019 · External reference
The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update
10.1093/nar/gky379 · 2018 · External reference
Unresolved reference
2010 · External reference
fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · 2018 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
Normalization of RNA-seq data using factor analysis of control genes or samples
10.1038/nbt.2931 · 2014 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Ensembl 2023.
10.1093/nar/gkac958 · 2023 · External reference
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update).
10.1093/nar/gkz369 · 2019 · External reference
Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ12-PGJ₂ acting through PPARγ-dependent and independent pathways
10.1016/j.gene.2012.05.052 · 2012 · External reference
Arginine-dependent immune responses.
10.1007/s00018-021-03828-4 · 2021 · External reference
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy
10.1016/j.molcel.2020.09.006 · 2020 · External reference
Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
10.1074/jbc.m111.224626 · 2011 · External reference
Down-regulation of layilin, a novel hyaluronan receptor, via RNA interference, inhibits invasion and lymphatic metastasis of human lung A549 cells
10.1042/ba20070138 · 2008 · External reference
Cigarette Smoke-Induced Pulmonary Inflammation and Autophagy Are Attenuated in Ephx2-Deficient Mice.
10.1007/s10753-016-0495-z · 2017 · External reference
Understanding tumor-infiltrating lymphocytes by single cell RNA sequencing
10.1016/bs.ai.2019.08.004 · 2019 · External reference
Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1.
10.1111/febs.14425 · 2018 · External reference
Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression
10.1080/08977194.2023.2227272 · 2023 · External reference
AHR Regulates NK Cell Migration via ASB2-Mediated Ubiquitination of Filamin A.
10.3389/fimmu.2021.624284 · 2021 · External reference
ASB2α regulates migration of immature dendritic cells
10.1182/blood-2012-11-466649 · 2013 · External reference
CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells
10.1182/blood-2005-07-2913 · 2006 · External reference
Pathophysiological impact of the adhesion G protein-coupled receptor family
10.1152/ajpcell.00445.2021 · 2022 · External reference
Streptococcus pneumoniae promotes migration and invasion of A549 cells in vitro by activating mTORC2/AKT through up-regulation of DDIT4 expression.
10.3389/fmicb.2022.1046226 · 2022 · External reference
Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation
10.1016/j.devcel.2016.07.014 · 2016 · External reference
Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and Function.
2019 · External reference
Spred is a Sprouty-related suppressor of Ras signalling
10.1038/35088082 · 2001 · External reference
CD69 controls the pathogenesis of allergic airway inflammation
10.4049/jimmunol.0900646 · 2009 · External reference
Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes
10.1016/j.prostaglandins.2004.11.003 · 2005 · External reference
Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma
10.1136/thx.2003.013573 · 2004 · External reference
Induced sputum eicosanoids during aspirin bronchial challenge of asthmatic patients with aspirin hypersensitivity
10.1111/all.12512 · 2014 · External reference
Innate and adaptive γδ T cells: How, when, and why
10.1111/imr.12926 · 2020 · External reference
Waves of layered immunity over innate lymphoid cells
10.3389/fimmu.2022.957711 · 2022 · External reference
Abortive γδTCR rearrangements suggest ILC2s are derived from T-cell precursors
10.1182/bloodadvances.2020002758 · 2020 · External reference
β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration.
10.3389/fimmu.2021.775447 · 2021 · External reference
Dysregulated Expression of RPS4Y1 (Ribosomal Protein S4, Y-Linked 1) Impairs STAT3 (Signal Transducer and Activator of Transcription 3) Signaling to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia.
10.1161/hypertensionaha.117.10250 · 2018 · External reference
L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling.
10.3389/fimmu.2019.01068 · 2019 · External reference
Transcriptome analysis reveals similarities between human blood CD3- CD56bright cells and mouse CD127+ innate lymphoid cells.
10.1038/s41598-017-03256-0 · 2017 · External reference
RNA-seq Data: Challenges in and Recommendations for Experimental Design and Analysis.
2014 · External reference
A Phase 2a Study of DP2 Antagonist GB001 for Asthma
10.1016/j.jaip.2019.11.016 · 2020 · External reference
Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma
10.1111/bph.12053 · 2013 · External reference