Research graph
References from Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells. Local targets link to admitted publications; unresolved targets remain external evidence.
The innate immune function of airway epithelial cells in inflammatory lung disease
10.1183/09031936.00141514 · 2015 · External reference
Role of epithelial sodium channels in the regulation of lung fluid homeostasis
10.1152/ajplung.00319.2015 · 2015 · External reference
Regulation of airway surface liquid volume and mucus transport by active ion transport
10.1513/pats.2306014 · 2004 · External reference
Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines
10.3389/fimmu.2017.00766 · 2017 · External reference
Mechanisms of pulmonary edema clearance
10.1152/ajplung.00247.2005 · 2005 · External reference
Alveolar Fluid Clearance Is Impaired in the Majority of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome
2001 · External reference
Regulation of the epithelial sodium channel (ENaC) by membrane trafficking
10.1016/j.bbadis.2010.03.010 · 2010 · External reference
Membrane trafficking pathways regulating the epithelial Na(+) channel
10.1152/ajprenal.00277.2019 · 2020 · External reference
Epithelial Na(+) Channel Regulation by Extracellular and Intracellular Factors
10.1146/annurev-physiol-021317-121143 · 2018 · External reference
Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s gamma-subunit
10.1016/j.jbc.2022.102004 · 2022 · External reference
Regulation of epithelial sodium channel trafficking by ubiquitination
10.1513/pats.200909-096js · 2010 · External reference
The Epithelial Sodium Channel-An Underestimated Drug Target
10.3390/ijms24097775 · 2023 · External reference
Epithelial Sodium Channel δ Subunit Is Expressed in Human Arteries and Has Potential Association With Hypertension
10.1161/hypertensionaha.122.18924 · 2022 · External reference
Trafficking and cell surface stability of ENaC
10.1152/ajprenal.2001.281.3.f391 · 2001 · External reference
Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gamma
10.1152/ajplung.2000.278.6.l1186 · 2000 · External reference
The regulation of amiloride-sensitive epithelial sodium channels by tumor necrosis factor-alpha in injured lungs and alveolar type II cells
10.1016/j.resp.2008.12.008 · 2009 · External reference
Downregulation of ENaC activity and expression by TNF-alpha in alveolar epithelial cells
10.1152/ajplung.00326.2002 · 2004 · External reference
Regulation of airway tight junctions by proinflammatory cytokines
10.1091/mbc.e02-03-0134 · 2002 · External reference
The Effects of IFN-lambda on Epithelial Barrier Function Contribute to Klebsiella pneumoniae ST258 Pneumonia
10.1165/rcmb.2018-0021oc · 2019 · External reference
Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-gamma and IL-4
10.1016/j.jaci.2012.05.052 · 2012 · External reference
TNF-alpha-mediated bronchial barrier disruption and regulation by src-family kinase activation
10.1016/j.jaci.2013.03.005 · 2013 · External reference
TNF-alpha disrupts the integrity of the porcine respiratory epithelial barrier
10.1016/j.rvsc.2019.01.029 · 2019 · External reference
IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro
10.4049/jimmunol.168.2.839 · 2002 · External reference
Interleukin-13 Alters Tight Junction Proteins Expression Thereby Compromising Barrier Function and Dampens Rhinovirus Induced Immune Responses in Nasal Epithelium
10.3389/fcell.2020.572749 · 2020 · External reference
More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis
10.3389/fimmu.2020.00761 · 2020 · External reference
IL-13 Impairs Tight Junctions in Airway Epithelia
10.3390/ijms20133222 · 2019 · External reference
Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism
10.1074/jbc.m304882200 · 2003 · External reference
Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation
10.1136/thoraxjnl-2011-200393 · 2012 · External reference
TGF-beta directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury
10.1073/pnas.1306798111 · 2014 · External reference
Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation
10.1186/1465-9921-8-75 · 2007 · External reference
Tight junctions in pulmonary epithelia during lung inflammation
10.1007/s00424-016-1917-3 · 2017 · External reference
An Amino Acid-Based Oral Rehydration Solution Regulates Radiation-Induced Intestinal Barrier Disruption in Mice
10.1093/jn/nxaa025 · 2020 · External reference
An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation
10.1038/srep37220 · 2016 · External reference
Proprietary Blend of Amino Acids Decreased IL-13 Induced Hypersecretion and Inflammation in Primary Human Bronchial Epithelial Cells
2020 · External reference
A new mathematical model for relative quantification in real-time RT-PCR
10.1093/nar/29.9.e45 · 2001 · External reference
The value of serum interferon-gamma level in the differential diagnosis of active and inactive pulmonary tuberculosis
2006 · External reference
Plasma levels of tumor necrosis factor in the adult respiratory distress syndrome
10.1164/ajrccm/143.3.590 · 1991 · External reference
Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls
10.1136/thorax.55.1.46 · 2000 · External reference
Association between tumor necrosis factor-alpha and chronic obstructive pulmonary disease: a systematic review and meta-analysis
10.1177/1753466619866096 · 2019 · External reference
Effects of probiotics on ghrelin and lungs in children with acute lung injury: A double-blind randomized, controlled trial
10.1002/ppul.23922 · 2018 · External reference
Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome
10.1111/j.1365-2249.2004.02415.x · 2004 · External reference
Mucus clearance as a primary innate defense mechanism for mammalian airways
10.1172/jci0215217 · 2002 · External reference
Effect of inflammatory stimuli on airway ion transport
10.1513/pats.2306017 · 2004 · External reference
Changes in ion transport in inflammatory disease
10.1186/1476-9255-3-5 · 2006 · External reference
Tumor Necrosis Factor-α and Angiostatin Are Mediators of Endothelial Cytotoxicity in Bronchoalveolar Lavages of Patients with Acute Respiratory Distress Syndrome
10.1164/rccm.2109004 · 2002 · External reference
Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections
10.3389/fimmu.2017.00446 · 2017 · External reference
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
10.1016/j.cytogfr.2020.06.001 · 2020 · External reference
Differential Translational Efficiency of ENaC Subunits During Lung Development
10.1165/rcmb.2003-0381oc · 2004 · External reference
Epithelial Na(+) Channel (ENaC) Formed by One or Two Subunits Forms Functional Channels That Respond to Shear Force
10.3389/fphys.2020.00141 · 2020 · External reference
Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases
10.1016/j.gene.2015.12.061 · 2016 · External reference
delta ENaC: a novel divergent amiloride-inhibitable sodium channel
10.1152/ajplung.00206.2012 · 2012 · External reference
The delta subunit of epithelial sodium channel in humans-a potential player in vascular physiology
10.1152/ajpheart.00800.2020 · 2021 · External reference
Structure and regulation of amiloride-sensitive sodium channels
10.1146/annurev.physiol.62.1.573 · 2000 · External reference
Epithelial sodium channel inhibition in primary human bronchial epithelia by transfected siRNA
10.1165/rcmb.2007-0456oc · 2009 · External reference
Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
2021 · External reference
Tumor Necrosis Factor-alpha Mediates Lung Injury in the Early Phase of Endotoxemia
2022 · External reference
Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration
10.3389/fimmu.2021.589095 · 2021 · External reference
The Mechanism behind Influenza Virus Cytokine Storm
2021 · External reference
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation
2014 · External reference
Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium
10.1152/ajplung.2001.280.6.l1258 · 2001 · External reference
TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1B
10.3389/fimmu.2017.00601 · 2017 · External reference
Dichotomous Role of Tumor Necrosis Factor in Pulmonary Barrier Function and Alveolar Fluid Clearance
10.3389/fphys.2021.793251 · 2021 · External reference
Dichotomal role of TNF in experimental pulmonary edema reabsorption
10.4049/jimmunol.175.5.3402 · 2005 · External reference
Essential structural features of TNF-alpha lectin-like domain derived peptides for activation of amiloride-sensitive sodium current in A549 cells
10.1021/jm100767p · 2010 · External reference
IFN-gamma Drives TNF-alpha Hyperproduction and Lethal Lung Inflammation during Antibiotic Treatment of Postinfluenza Staphylococcus aureus Pneumonia
10.4049/jimmunol.2100328 · 2021 · External reference
Off balance: Interferons in COVID-19 lung infections
10.1016/j.ebiom.2021.103642 · 2021 · External reference
Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection
10.1084/jem.20160880 · 2017 · External reference
The Dual Nature of Type I and Type II Interferons
2018 · External reference
Cytokine regulation of tight junctions
10.1016/j.bbamem.2008.08.027 · 2009 · External reference
Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-y
10.1152/ajpcell.2001.281.6.c2029 · 2001 · External reference
Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity
10.1016/j.coi.2007.08.004 · 2007 · External reference
Cytoskeletal regulation of epithelial barrier function during inflammation
10.2353/ajpath.2010.100168 · 2010 · External reference
Serum levels of TNF-α, IL-1β, IL-9, and IL-15 in acute respiratory distress syndrome
2017 · External reference
Synergism of TNF-alpha and IFN-gamma Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
10.1016/j.cell.2020.11.025 · 2021 · External reference
Lower Circulating Interferon-Gamma Is a Risk Factor for Lung Fibrosis in COVID-19 Patients
10.3389/fimmu.2020.585647 · 2020 · External reference
10.1093/nsr/nwaa037
10.1093/nsr/nwaa037 · External reference
Duality of Interactions Between TGF-β and TNF-α During Tumor Formation
2022 · External reference
The plasticity of human Treg and Th17 cells and its role in autoimmunity
10.1016/j.smim.2013.10.009 · 2013 · External reference
Regulation of the Immune Response by TGF-beta: From Conception to Autoimmunity and Infection
10.1101/cshperspect.a022236 · 2017 · External reference
Regulatory cytokine function in the respiratory tract
10.1038/s41385-019-0158-0 · 2019 · External reference
Transforming growth factor-β in stem cells and tissue homeostasis
10.1038/s41413-017-0005-4 · 2018 · External reference
Transforming Growth Factor-beta Signaling in Immunity and Cancer
10.1016/j.immuni.2019.03.024 · 2019 · External reference
Cellular and molecular basis for the regulation of inflammation by TGF-beta
10.1093/jb/mvq043 · 2010 · External reference
