Research graph
References from Cancer-wide in silico analyses using differentially expressed genes demonstrate the functions and clinical relevance of JAG, DLL, and NOTCH. Local targets link to admitted publications; unresolved targets remain external evidence.
Notch signalling in context
10.1038/nrm.2016.94 · 2016 · External reference
Notch as a tumour suppressor
10.1038/nrc.2016.145 · 2017 · External reference
The canonical Notch signaling pathway: unfolding the activation mechanism
10.1016/j.cell.2009.03.045 · 2009 · External reference
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells
10.1073/pnas.1000896107 · 2010 · External reference
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
10.1038/nrclinonc.2015.61 · 2015 · External reference
DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation
10.1074/jbc.a111.236612 · 2017 · External reference
Glycogen synthase kinase-3beta modulates notch signaling and stability
10.1016/s0960-9822(02)00888-6 · 2002 · External reference
Glycogen synthase kinase 3-β phosphorylates novel S/T-P-S/T domains in Notch1 intracellular domain and induces its nuclear localization
10.1016/j.bbrc.2012.05.111 · 2012 · External reference
Role of STRAP in regulating GSK3β function and Notch3 stabilization
10.4161/cc.10.10.15630 · 2011 · External reference
Therapeutic modulation of Notch signalling—are we there yet?
10.1038/nrd4252 · 2014 · External reference
Targeting Notch to target cancer stem cells
10.1158/1078-0432.ccr-09-2823 · 2010 · External reference
Notch and cancer: a double-edged sword
10.1007/s00018-007-7164-1 · 2007 · External reference
Notch signalling in solid tumours: a little bit of everything but not all the time
10.1038/nrc3035 · 2011 · External reference
A Landscape of Pharmacogenomic Interactions in Cancer
10.1016/j.cell.2016.06.017 · 2016 · External reference
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy
10.1126/science.aaf8399 · 2017 · External reference
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
10.1016/j.cell.2014.06.049 · 2014 · External reference
Prediction of individual response to anticancer therapy: historical and future perspectives
10.1007/s00018-014-1772-3 · 2015 · External reference
Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery.
10.1016/j.chembiol.2017.06.012 · 2017 · External reference
GlioVis data portal for visualization and analysis of brain tumor expression datasets
10.1093/neuonc/now247 · 2017 · External reference
Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma
10.1186/s40478-022-01372-1 · 2022 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
10.1093/nar/gkq537 · 2010 · External reference
Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity
10.1016/j.ccell.2022.02.016 · 2022 · External reference
Comprehensive Integration of Single-Cell Data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
10.1038/s41590-018-0276-y · 2019 · External reference
The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments
10.1074/jbc.m302659200 · 2003 · External reference
IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation
10.1038/s41419-018-1185-6 · 2018 · External reference
Kras/ADAM17-Dependent Jag1-ICD Reverse Signaling Sustains Colorectal Cancer Progression and Chemoresistance
10.1158/0008-5472.can-19-0145 · 2019 · External reference
The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2
10.1016/j.celrep.2022.111626 · 2022 · External reference
Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion
10.1038/s41419-023-06356-0 · 2023 · External reference
Molecular docking analysis of cetuximab with NOTCH signalling pathway targets for oral cancer
10.6026/97320630019471 · 2023 · External reference
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
10.1371/journal.pone.0119723 · 2015 · External reference
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer
10.1038/s42003-023-04828-9 · 2023 · External reference
Notch signaling pathway: architecture, disease, and therapeutics.
10.1038/s41392-022-00934-y · 2022 · External reference
A spatially resolved single-cell genomic atlas of the adult human breast
10.1038/s41586-023-06252-9 · 2023 · External reference
Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer
10.1016/j.ccell.2019.08.007 · 2019 · External reference
Identification of DLL3-related genes affecting the prognosis of patients with colon adenocarcinoma.
10.3389/fgene.2023.1098190 · 2023 · External reference
Prognostic significance of DLL4 expression in papillary thyroid cancer
2015 · External reference
The expression profile of Jagged1 and Delta-like 4 in hepatocellular carcinoma
2021 · External reference
Understanding and targeting cancer stem cells: therapeutic implications and challenges
10.1038/aps.2013.27 · 2013 · External reference
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency
10.1016/j.stem.2009.05.019 · 2009 · External reference
The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of NOTCH signaling activation
10.1158/1535-7163.mct-14-0501 · 2015 · External reference
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
10.1038/sj.emboj.7600069 · 2004 · External reference
Regulation of angiogenesis by hypoxia: role of the HIF system
10.1038/nm0603-677 · 2003 · External reference
RAS oncogenes: weaving a tumorigenic web
10.1038/nrc3106 · 2011 · External reference
RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer.
10.1038/cddis.2014.445 · 2014 · External reference
Notch signaling regulates tumor angiogenesis by diverse mechanisms
10.1038/onc.2008.227 · 2008 · External reference
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
10.1016/j.cell.2009.03.025 · 2009 · External reference
Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
10.1016/j.ccr.2005.06.004 · 2005 · External reference
Overexpression of Jagged-1 and its intracellular domain in human mesenchymal stromal cells differentially affect the interaction with hematopoietic stem and progenitor cells
10.1089/scd.2012.0638 · 2013 · External reference
Defective intracellular transport and processing of JAG1 missense mutations in Alagille syndrome
10.1093/hmg/10.4.405 · 2001 · External reference
Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart
10.1093/cvr/cvv209 · 2015 · External reference
The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase
10.1016/j.yexcr.2011.07.014 · 2011 · External reference
