Research graph
References from The effects of CYP2B6 inactivators on the metabolism of ciprofol. Local targets link to admitted publications; unresolved targets remain external evidence.
Design, synthesis, and evaluation of novel 2,6-disubstituted phenol derivatives as general anesthetics
10.1021/acs.jmedchem.7b00254 · 2017 · External reference
Efficacy and safety of HSK3486 compared to propofol in induction of general anesthesia in adults having elective surgery
External reference
Population pharmacokinetic/pharmacodynamic modeling and exposure-response analysis of ciprofol in the induction and maintenance of general anesthesia in patients undergoing elective surgery: a prospective dose optimization study
10.1016/j.jclinane.2023.111317 · 2024 · External reference
Pharmacodynamics and pharmacokinetics of HSK3486, a novel 2,6-disubstituted phenol derivative as a general anesthetic.
10.3389/fphar.2022.830791 · 2022 · External reference
Efficacy and safety of HSK3486 for anesthesia/sedation in patients undergoing fiberoptic bronchoscopy: a multicenter, double-blind, propofol-controlled, randomized, phase 3 Study.
10.1007/s40263-021-00890-1 · 2022 · External reference
Safety and efficacy of ciprofol vs. propofol for sedation in intensive care unit patients with mechanical ventilation: a multi-center, open label, randomized, phase 2 trial
10.1097/cm9.0000000000001912 · 2022 · External reference
Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: phase IIa and IIb multi-center clinical trials
10.1016/j.ejps.2021.105904 · 2021 · External reference
Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects
10.1111/bcp.14363 · 2021 · External reference
Ciprofol is primarily glucuronidated by UGT1A9 and predicted not to cause drug-drug interactions with typical substrates of CYP1A2, CYP2B6, and CYP2C19
10.1016/j.cbi.2023.110811 · 2024 · External reference
Drug-drug interaction of ciprofol injectable emulsion with mefenamic acid capsules in healthy subjects
10.1111/bcp.15822 · 2023 · External reference
Psoralen and ultraviolet a light therapy for psoriasis
10.1056/nejmct072317 · 2007 · External reference
A review of the pharmacological properties of psoralen.
10.3389/fphar.2020.571535 · 2020 · External reference
Clopidogrel pharmacogenetics
10.1161/circinterventions.119.007811 · 2019 · External reference
Psoralen, a mechanism-based inactivator of CYP2B6
10.1016/j.cbi.2015.08.020 · 2015 · External reference
Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine
10.1124/jpet.103.056127 · 2004 · External reference
Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6
10.1177/0091270006293753 · 2006 · External reference
Unresolved reference
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Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of psoraleae fructus in rats after oral administration.
10.1016/j.phymed.2017.12.002 · 2018 · External reference
Effects of psoralen on the pharmacokinetics of anastrozole in rats.
10.1080/13880209.2018.1501584 · 2018 · External reference
Psoralen, a natural phytoestrogen, improves diaphyseal fracture healing in ovariectomized mice: a preliminary study.
10.3892/etm.2021.9799 · 2021 · External reference
Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice
10.1016/j.toxlet.2011.11.030 · 2012 · External reference
Medial septal cholinergic neurons modulate isoflurane anesthesia
10.1097/aln.0b013e3182a7cab6 · 2014 · External reference
High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery
10.1146/annurev.pharmtox.40.1.133 · 2000 · External reference
Ciprofol: a novel alternative to propofol in clinical intravenous anesthesia
10.1155/2023/7443226 · 2023 · External reference
Efficacy and safety of ciprofol sedation in ICU patients undergoing mechanical ventilation: a multicenter, single-blind, randomized, noninferiority trial.
10.1097/ccm.0000000000005920 · 2023 · External reference
Efficacy and safety of ciprofol for procedural sedation and anesthesia in non-operating room settings
10.1016/j.jclinane.2022.111047 · 2023 · External reference
The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico
10.2174/138920006778520633 · 2006 · External reference
Insights into CYP2B6-mediated drug-drug interactions.
10.1016/j.apsb.2016.07.016 · 2016 · External reference
Mechanism-based inactivation of cytochrome P450 2B6 by isopsoralen
10.3109/00498254.2015.1077403 · 2016 · External reference
Coordination mechanism and bio-evidence: reactive γ-Ketoenal intermediated hepatotoxicity of psoralen and isopsoralen based on computer approach and bioassay.
10.3390/molecules22091451 · 2017 · External reference
Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine
10.2133/dmpk.23.412 · 2008 · External reference
Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel
10.1124/dmd.108.022988 · 2009 · External reference
Simultaneous determination of multiple components in rat plasma and pharmacokinetic studies at a pharmacodynamic dose of Xian-Ling-Gu-Bao capsule by UPLC-MS/MS
10.1016/j.jpba.2019.112836 · 2020 · External reference
Study on pharmacokinetics of eight active compounds from Bufei-Huoxue Capsule based on UHPLC-MS/MS
10.1016/j.jchromb.2021.122974 · 2021 · External reference
Determination of multicomponents from Zhuanggu Guanjie capsule in rat plasma by UHPLC-MS/MS and pharmacokinetic study.
10.4155/bio-2022-0238 · 2023 · External reference
Established UPLC-MS/MS procedure for multicomponent quantitative analysis in rat plasma: A contrastive pharmacokinetics study of Qiangshen tablet in normal and kidney yang deficiency syndrome models
10.1016/j.jchromb.2018.12.031 · 2019 · External reference
American college of surgeons’ guidelines for the perioperative management of antithrombotic medication.
10.1016/j.jamcollsurg.2018.08.183 · 2018 · External reference
Guidelines on the assessment of bleeding risk prior to surgery or invasive procedures
10.1111/j.1365-2141.2007.06968.x · 2008 · External reference
Multidisciplinary expert consensus on perioperative management of antithrombotic drugs.
2020 · External reference
A meta-analysis of the impact of aspirin, clopidogrel, and dual antiplatelet therapy on bleeding complications in noncardiac surgery
10.1097/sla.0000000000002279 · 2018 · External reference
Safety of clopidogrel being continued until the time of coronary artery bypass grafting in patients with acute coronary syndrome: a meta-analysis of 34 studies
10.1093/eurheartj/ehr151 · 2011 · External reference
Safety of continued clopidogrel use in the preoperative course of gastrointestinal surgery: a retrospective cohort study
10.1097/sla.0000000000001726 · 2017 · External reference
Safety of not withholding clopidogrel therapy during the immediate several days pre- and post-trans-urethral resection of prostate (TURP): a retrospective cohort study.
10.1007/s11255-022-03147-y · 2022 · External reference
Is it safe to continue clopidogrel in elective hip and knee arthroplasty?
10.1016/j.arth.2022.04.005 · 2022 · External reference
