Research graph
References from CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
10.1016/s2213-2600(17)30293-x · 2017 · External reference
Immunobiology of asthma
10.1146/annurev.physiol.010908.163200 · 2009 · External reference
New treatments for severe treatment-resistant asthma: targeting the right patient
10.1016/s2213-2600(13)70128-0 · 2013 · External reference
The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules
10.1016/0092-8674(93)90625-z · 1993 · External reference
Immunomodulatory Functions of Neuronal Guidance Proteins
10.1016/j.it.2017.03.007 · 2017 · External reference
Semaphorins and their Signaling Mechanisms
10.1007/978-1-4939-6448-2_1 · 2017 · External reference
PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla
10.1016/j.immuni.2008.10.008 · 2008 · External reference
Semaphorins and Their Roles in Airway Biology: Potential as Therapeutic Targets
10.1165/rcmb.2017-0171tr · 2018 · External reference
Targeting the Semaphorin3E-plexinD1 complex in allergic asthma
10.1016/j.pharmthera.2023.108351 · 2023 · External reference
Current drug design to target the Semaphorin/Neuropilin/Plexin complexes
10.1080/19336918.2016.1261785 · 2016 · External reference
Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins
10.1126/science.1105416 · 2005 · External reference
Semaphorins and plexins as therapeutic targets
10.1038/nrd4337 · 2014 · External reference
Chemorepellent Semaphorin 3E Negatively Regulates Neutrophil Migration In Vitro and In Vivo
10.4049/jimmunol.1601093 · 2017 · External reference
Downregulation of semaphorin 3E promotes hallmarks of experimental chronic allergic asthma
10.18632/oncotarget.22144 · 2017 · External reference
Neuronal chemorepellent Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration
10.1016/j.jaci.2013.06.011 · 2014 · External reference
Semaphorin 3E Alleviates Hallmarks of House Dust Mite-Induced Allergic Airway Disease
10.1016/j.ajpath.2017.03.008 · 2017 · External reference
Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence
10.1371/journal.pone.0252868 · 2021 · External reference
Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma
10.4049/jimmunol.1601514 · 2017 · External reference
Semaphorin 3E Inhibits House Dust Mite-Induced Angiogenesis in a Mouse Model of Allergic Asthma
10.1016/j.ajpath.2019.01.008 · 2019 · External reference
PlexinD1 Deficiency in Lung Interstitial Macrophages Exacerbates House Dust Mite-Induced Allergic Asthma
10.4049/jimmunol.2100089 · 2022 · External reference
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
10.1146/annurev-immunol-020711-074950 · 2013 · External reference
Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis
10.1073/pnas.1314209111 · 2014 · External reference
Dendritic cells suppress IgE production in B cells
10.1093/intimm/dxl138 · 2007 · External reference
Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes
10.1084/jem.185.5.941 · 1997 · External reference
Pulmonary inflammation induced by a recombinant Brugia malayi gamma-glutamyl transpeptidase homolog: involvement of humoral autoimmune responses
10.1007/bf03402217 · 2001 · External reference
Simple method of estimating severity of pulmonary fibrosis on a numerical scale
10.1136/jcp.41.4.467 · 1988 · External reference
Stability of Reference Genes for Messenger RNA Quantification by Real-Time PCR in Mouse Dextran Sodium Sulfate Experimental Colitis
10.1371/journal.pone.0156289 · 2016 · External reference
Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling
10.1164/rccm.200308-1094oc · 2004 · External reference
Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease
10.1164/rccm.200905-0736oc · 2011 · External reference
Issues determining direct airways hyperresponsiveness in mice
10.3389/fphys.2012.00408 · 2012 · External reference
The Cytokines of Asthma
10.1016/j.immuni.2019.03.018 · 2019 · External reference
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
10.1038/nri3712 · 2014 · External reference
Lung dendritic cells have a potent capability to induce production of immunoglobulin A
10.1165/rcmb.2007-0237oc · 2008 · External reference
Potential of immunoglobulin A to prevent allergic asthma
10.1155/2013/542091 · 2013 · External reference
Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production
10.1371/journal.pone.0043333 · 2012 · External reference
Airway remodelling in asthma: from benchside to clinical practice
10.1155/2010/318029 · 2010 · External reference
Human dendritic cell 1 and dendritic cell 2 subsets express FcepsilonRI: correlation with serum IgE and allergic asthma
10.1016/j.jaci.2003.09.011 · 2003 · External reference
Mechanisms of allergen-specific immunotherapy
10.1016/j.jaci.2007.01.022 · 2007 · External reference
IgE in allergy and asthma today
10.1038/nri2273 · 2008 · External reference
Semaphorin-3E Produced by Immature Dendritic Cells Regulates Activated Natural Killer Cells Migration
10.3389/fimmu.2018.01005 · 2018 · External reference
Plexin-D1 is a novel regulator of germinal centers and humoral immune responses
10.4049/jimmunol.1003464 · 2011 · External reference
Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen
10.1016/j.immuni.2012.10.016 · 2013 · External reference
Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses
10.1165/rcmb.2011-0070oc · 2012 · External reference
Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance
10.4049/jimmunol.1300193 · 2013 · External reference
The airway epithelium in asthma
10.1038/nm.2737 · 2012 · External reference
Alveolar macrophages: plasticity in a tissue-specific context
10.1038/nri3600 · 2014 · External reference
Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma
10.1165/rcmb.2014-0255oc · 2015 · External reference
Monocyte chemoattractant protein-1 (MCP-1): an overview
10.1089/jir.2008.0027 · 2009 · External reference
Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways
10.1016/j.imbio.2008.01.003 · 2008 · External reference
Tumor necrosis factor-α signaling in macrophages
10.1615/critreveukargeneexpr.v20.i2.10 · 2010 · External reference
TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection
10.1073/pnas.211423598 · 2001 · External reference
Semaphorin 3E Regulates the Response of Macrophages to Lipopolysaccharide-Induced Systemic Inflammation
10.4049/jimmunol.1801514 · 2020 · External reference
Airway hyperresponsiveness: new insights into the pathogenesis
10.1055/s-0032-1325617 · 2012 · External reference
Biology of lung dendritic cells at the origin of asthma
10.1016/j.immuni.2009.08.008 · 2009 · External reference
Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge
10.1136/thx.2006.067793 · 2007 · External reference
The immunology of asthma
10.1038/ni.3049 · 2015 · External reference
The development and function of lung-resident macrophages and dendritic cells
10.1038/ni.3052 · 2015 · External reference
Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells
10.4049/jimmunol.163.4.2160 · 1999 · External reference
10.1186/rr13 · 2000 · Admitted local publication
Pathobiology of severe asthma
10.1146/annurev-pathol-012414-040343 · 2015 · External reference
Airway mucus hypersecretion in asthma: an undervalued pathology?
10.1016/j.coph.2004.01.011 · 2004 · External reference
Taking our breath away: dendritic cells in the pathogenesis of asthma
10.1038/nri1249 · 2003 · External reference
Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors
10.1074/jbc.271.30.17779 · 1996 · External reference
Circulating fibrocytes: collagen-secreting cells of the peripheral blood
10.1016/j.biocel.2003.10.005 · 2004 · External reference
Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2
10.1016/j.biocel.2008.02.016 · 2008 · External reference
IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling
10.4049/jimmunol.168.6.2953 · 2002 · External reference
MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium
10.1152/ajplung.00292.2010 · 2011 · External reference
Macrophages in Lung Injury, Repair, and Fibrosis
10.3390/cells10020436 · 2021 · External reference
Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects
10.1016/j.ydbio.2008.09.031 · 2009 · External reference
Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells
10.1016/j.ydbio.2008.06.028 · 2008 · External reference
Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis
10.15252/emmm.201404922 · 2015 · External reference
Complexes of plexin-A4 and plexin-D1 convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins
10.1242/jcs.208298 · 2018 · External reference
Neuroimmune semaphorin 4A as a drug and drug target for asthma
10.1016/j.intimp.2013.08.005 · 2013 · External reference
Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1
10.1038/sj.emboj.7601589 · 2007 · External reference
