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References from Ononin delays the development of osteoarthritis by down-regulating MAPK and NF-κB pathways in rat models. Local targets link to admitted publications; unresolved targets remain external evidence.
Articular cartilage: tissue design and chondrocyte-matrix interactions.
1998 · External reference
Effect of osteoarthritis on work participation and loss of working life-years
10.3899/jrheum.181284 · 2020 · External reference
[Non-pharmacological treatments for osteoarthritis: unavoidable and essential].
2019 · External reference
[Pharmacological treatments of knee osteoarthritis].
2019 · External reference
Osteoarthritis: a call for research on central pain mechanism and personalized prevention strategies.
10.1007/s10067-018-4270-4 · 2019 · External reference
Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review
10.1016/j.joca.2021.12.003 · 2022 · External reference
Inflammaging and osteoarthritis.
10.1007/s12016-022-08941-1 · 2023 · External reference
Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!).
10.1016/j.joca.2012.11.012 · 2013 · External reference
The role of cytokines in osteoarthritis pathophysiology.
2002 · External reference
Changes in content and synthesis of collagen types and proteoglycans in osteoarthritis of the knee joint and comparison of quantitative analysis with Photoshop-based image analysis
10.1007/s00402-009-0981-y · 2010 · External reference
Overview of MMP-13 as a promising target for the treatment of osteoarthritis
2021 · External reference
Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis.
10.2174/138945007779940115 · 2007 · External reference
Schisandra extract ameliorates arthritis pathogenesis by suppressing the NF-κB and MAPK signalling pathways
10.1111/jcmm.17814 · 2023 · External reference
Oleocanthal inhibits catabolic and inflammatory mediators in LPS-activated human primary osteoarthritis (OA) chondrocytes through MAPKs/NF-κB Pathways
10.1159/000493840 · 2018 · External reference
NF-κB and the transcriptional control of inflammation
10.1016/bs.ircmb.2017.07.007 · 2018 · External reference
NSAIDs relieve osteoarthritis (OA) pain, but cardiovascular safety in question even for diclofenac, ibuprofen, naproxen, and celecoxib: what are the alternatives?
10.1016/j.sjpain.2017.05.009 · 2017 · External reference
Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies.
10.1136/bjsports-2017-098043 · 2018 · External reference
The efficacy and safety of chinese herbal medicine in the treatment of knee osteoarthritis: An updated systematic review and meta-analysis of 56 randomized controlled trials.
2022 · External reference
The chemical structures, plant origins, ethnobotany and biological activities of homoisoflavanones.
10.1080/14786410903335174 · 2010 · External reference
Ononin alleviates DSS-induced colitis through inhibiting NLRP3 inflammasome via triggering mitophagy.
10.1002/iid3.776 · 2023 · External reference
Ononin relieves the thyroid cancer progression through targeting the caspase 3 and CD274 expression levels.
10.1248/bpb.b22-00796 · 2023 · External reference
Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress
10.1016/j.jare.2021.06.023 · 2021 · External reference
Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer’s disease in rats
10.1016/j.sjbs.2021.06.031 · 2021 · External reference
Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells
10.1016/j.molimm.2017.01.007 · 2017 · External reference
Tougu Xiaotong capsules may inhibit p38 MAPK pathway-mediated inflammation: In vivo and in vitro verification
10.1016/j.jep.2019.112390 · 2020 · External reference
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
10.1038/nrrheum.2016.136 · 2016 · External reference
Modifiable risk factors in knee osteoarthritis: treatment implications.
10.1007/s00296-019-04290-z · 2019 · External reference
Efficacy and safety of chinese herbal medicine for knee osteoarthritis: Systematic review and meta-analysis of randomized controlled trials.
10.1016/j.phymed.2022.154029 · 2022 · External reference
The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics
10.1007/s11306-019-1614-2 · 2019 · External reference
Ononin induces cell apoptosis and reduces inflammation in rheumatoid arthritis fibroblast-like synoviocytes by alleviating MAPK and NF-κB signaling pathways
2021 · External reference
Early osteoarthritis of the knee
10.1007/s00167-016-4068-3 · 2016 · External reference
Knee osteoarthritis: Current status and research progress in treatment (Review).
10.3892/etm.2023.12180 · 2023 · External reference
Osteoarthritis year 2011 in review: biology
10.1016/j.joca.2011.11.015 · 2012 · External reference
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
10.1016/j.cytogfr.2018.10.002 · 2018 · External reference
Cytokines and chemokines involved in osteoarthritis pathogenesis
10.3390/ijms22179208 · 2021 · External reference
Bioinformatics-led discovery of osteoarthritis biomarkers and inflammatory infiltrates
10.3389/fimmu.2022.871008 · 2022 · External reference
Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model
10.1016/j.phymed.2019.153095 · 2019 · External reference
Investigation of the efficacy of daidzein in experimental knee osteoarthritis-induced with monosodium iodoacetate in rats.
10.1007/s10067-020-04958-z · 2020 · External reference
Early knee osteoarthritis.
10.1136/rmdopen-2015-000062 · 2015 · External reference
Selective MMP-13 inhibitors: Promising agents for the therapy of osteoarthritis
10.2174/0929867326666181217153118 · 2020 · External reference
L-Theanine reduced the development of knee osteoarthritis in rats via its anti-inflammation and anti-matrix degradation actions: In vivo and in vitro study.
2020 · External reference
ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis
10.1002/jcb.23298 · 2011 · External reference
Matrix metalloproteinases: role in arthritis
10.2741/1817 · 2006 · External reference
Neferine inhibits expression of inflammatory mediators and matrix degrading enzymes in IL-1β-treated rat chondrocytes via suppressing MAPK and NF-κB signaling pathways
10.1007/s10753-019-01143-6 · 2020 · External reference
Collagenase gene regulation by pro-inflammatory cytokines in cartilage
10.2741/2080 · 2007 · External reference
Primary osteoarthritis early joint degeneration induced by endoplasmic reticulum stress is mitigated by resveratrol
10.1016/j.ajpath.2021.05.016 · 2021 · External reference
Osteoarthritis: Novel molecular mechanisms increase our understanding of the disease pathology
2021 · External reference
Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration
10.1016/j.matbio.2006.07.002 · 2006 · External reference
Pathological roles of MAPK signaling pathways in human diseases
10.1016/j.bbadis.2009.12.009 · 2010 · External reference
Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes
10.1074/jbc.m706508200 · 2007 · External reference
30 years of NF-κB: A blossoming of relevance to human pathobiology
10.1016/j.cell.2016.12.012 · 2017 · External reference
The NF-kappa B and I kappa B proteins: new discoveries and insights
10.1146/annurev.immunol.14.1.649 · 1996 · External reference
Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice
10.3892/ijmm.2021.5025 · 2021 · External reference
Treatment efficacy of single topical NSAID (S-Flurbiprofen Plaster) for knee symptoms and locomotive dysfunction in knee osteoarthritis patients.
10.2490/prm.20210029 · 2021 · External reference
