Research graph
References from Cardiac effects of OPA1 protein promotion in a transgenic animal model. Local targets link to admitted publications; unresolved targets remain external evidence.
Determinants and functions of mitochondrial behavior
10.1146/annurev-cellbio-101011-155756 · 2014 · External reference
Perspectives on: SGP symposium on mitochondrial physiology and medicine: metabolic homeostasis of the heart
10.1085/jgp.201210783 · 2012 · External reference
Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
10.1038/s41556-018-0133-0 · 2018 · External reference
Heart failure and mitochondrial dysfunction: The role of mitochondrial fission/fusion abnormalities and new therapeutic strategies
10.1097/01.fjc.0000432861.55968.a6 · 2014 · External reference
A mitochondrial delicacy: dynamin-related protein 1 and mitochondrial dynamics
2018 · External reference
Mitochondrial Function and Cell Size: An Allometric Relationship
10.1016/j.tcb.2017.02.006 · 2017 · External reference
Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
2014 · External reference
Mitochondrial dynamics, mitophagy and cardiovascular disease
10.1113/jp271301 · 2016 · External reference
Mitochondrial morphology and cardiovascular disease
10.1093/cvr/cvq237 · 2010 · External reference
Molecular regulation of mitochondrial dynamics in cardiac disease
10.1016/j.bbamcr.2017.03.006 · 2017 · External reference
Parkin-dependent mitophagy in the heart
10.1016/j.yjmcc.2015.11.023 · 2016 · External reference
Mitophagy and heart failure
10.1007/s00109-015-1254-6 · 2015 · External reference
Mitochondrial dysfunction in pathophysiology of heart failure
10.1172/jci120849 · 2018 · External reference
Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics
10.1002/embj.201386474 · 2014 · External reference
Oxidative Stress in Cardiac and Skeletal Muscle Dysfunction Associated with Diabetes Mellitus
10.3164/jcbn.11-012fr · 2011 · External reference
Role of oxidative stress in cardiac hypertrophy and remodeling
2007 · External reference
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury
10.1161/circulationaha.109.906610 · 2010 · External reference
Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity
10.1093/hmg/ddy335 · 2019 · External reference
Dysregulation of Mfn2 and Drp-1 proteins in heart failure
10.1139/cjpp-2014-0060 · 2014 · External reference
Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor
10.1371/journal.pone.0077713 · 2013 · External reference
Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study
10.3390/ijms20163972 · 2019 · External reference
Differential temporal inhibition of mitochondrial fission by Mdivi-1 exerts effective cardioprotection in cardiac ischemia/reperfusion injury
2018 · External reference
Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes
10.1016/j.redox.2020.101660 · 2020 · External reference
Mitochondrial function as a therapeutic target in heart failure
10.1038/nrcardio.2016.203 · 2017 · External reference
Mitochondria and cardiovascular diseases—from pathophysiology to treatment
10.21037/atm.2018.06.21 · 2018 · External reference
Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
10.1038/s41569-018-0074-0 · 2019 · External reference
Mitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure
2011 · External reference
OPA1 processing in cell death and disease–the long and short of it
10.1242/jcs.159186 · 2016 · External reference
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
10.1083/jcb.201308006 · 2014 · External reference
Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress
10.1016/j.celrep.2016.02.011 · 2016 · External reference
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence
10.1016/j.cmet.2017.04.021 · 2017 · External reference
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency
10.1016/j.cell.2013.08.032 · 2013 · External reference
Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models
10.1016/j.cmet.2015.04.016 · 2015 · External reference
Opa1 Overexpression Protects from Early-Onset Mpv17−/−-Related Mouse Kidney Disease
10.1016/j.ymthe.2020.06.010 · 2020 · External reference
The Effects of Bradykinin B1 Receptor Antagonism on the Myocardial and Vascular Consequences of Hypertension in SHR Rats
10.3389/fphys.2019.00624 · 2019 · External reference
Mitochondrial protective effects of PARP-inhibition in hypertension-induced myocardial remodeling and in stressed cardiomyocytes
10.1016/j.lfs.2020.118936 · 2021 · External reference
Mitochondrial OPA1, apoptosis, and heart failure
10.1093/cvr/cvp181 · 2009 · External reference
OPA1 Mutation and Late‐Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability
10.1161/jaha.112.003012 · External reference
Increase in Cardiac Ischemia-Reperfusion Injuries in Opa1+/- Mouse Model
10.1371/journal.pone.0164066 · 2016 · External reference
OPA1: How much do we know to approach therapy?
10.1016/j.phrs.2018.02.018 · 2018 · External reference
Eight human OPA1 isoforms, long and short: What are they for?
10.1016/j.bbabio.2018.01.005 · 2018 · External reference
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy
10.1038/79936 · 2000 · External reference
Characterization of OPA1 isoforms isolated from mouse tissues
10.1111/j.1471-4159.2008.05401.x · 2008 · External reference
OPA1 and cardiolipin team up for mitochondrial fusion
10.1038/ncb3565 · 2017 · External reference
Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion
10.1016/j.bbabio.2018.05.016 · 2018 · External reference
OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation
10.1093/hmg/ddq088 · 2010 · External reference
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L
10.1083/jcb.200704110 · 2007 · External reference
OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions
10.1016/j.celrep.2017.05.073 · 2017 · External reference
Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space
10.1007/s11427-021-1962-0 · 2022 · External reference
The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock
10.1016/j.bbabio.2012.05.001 · 2012 · External reference
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
10.1083/jcb.200906084 · 2009 · External reference
OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy
10.1172/jci157504 · External reference
Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage
10.1083/jcb.200704112 · 2007 · External reference
AAA Proteases: Guardians of Mitochondrial Function and Homeostasis
10.3390/cells7100163 · 2018 · External reference
Quality Control of Mitochondrial Proteostasis
10.1101/cshperspect.a007559 · 2011 · External reference
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice
10.1126/science.aad0116 · 2015 · External reference
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress
10.1074/jbc.ra119.010983 · 2020 · External reference
