Research graph
References from Isoscopoletin inhibits hepatocellular carcinoma cell proliferation via regulating glycolysis-related proteins. Local targets link to admitted publications; unresolved targets remain external evidence.
Tumour metabolism and its unique properties in prostate adenocarcinoma
10.1038/s41585-020-0288-x · 2020 · External reference
Understanding the Warburg effect: the metabolic requirements of cell proliferation
10.1126/science.1160809 · 2009 · External reference
Cancer Energy Metabolism: Shutting Power off Cancer Factory
10.4062/biomolther.2017.184 · 2018 · External reference
Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment
10.1186/s12916-021-01925-6 · 2021 · External reference
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma
10.1186/s12943-017-0748-y · 2017 · External reference
The secreted glycolytic enzyme GPI/AMF stimulates glioblastoma cell migration and invasion in an autocrine fashion but can have anti-proliferative effects
10.1093/neuonc/noy117 · 2018 · External reference
Scoparone as a therapeutic drug in liver diseases: Pharmacology, pharmacokinetics and molecular mechanisms of action
10.1016/j.phrs.2020.105170 · 2020 · External reference
Development and Application of an UHPLC-MS/MS Method for Comparative Pharmacokinetic Study of Eight Major Bioactive Components from Yin Chen Hao Tang in Normal and Acute Liver Injured Rats
10.1155/2018/3239785 · 2018 · External reference
Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats
10.1016/j.etp.2010.02.006 · 2011 · External reference
Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice
10.1016/j.intimp.2019.105797 · 2019 · External reference
Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages
10.1016/j.biopha.2020.109895 · 2020 · External reference
Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway
2020 · External reference
Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway
10.4251/wjgo.v13.i9.1164 · 2021 · External reference
Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity
10.1371/journal.pone.0080391 · 2013 · External reference
Stimulation of melanogenesis by scoparone in B16 melanoma cells
10.1111/j.1745-7254.2006.00435.x · 2006 · External reference
Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer
10.1016/j.lfs.2021.119105 · 2021 · External reference
SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation
10.1186/1471-2407-14-987 · 2014 · External reference
Scopoletin exerts anticancer effects on human cervical cancer cell lines by triggering apoptosis, cell cycle arrest, inhibition of cell invasion and PI3K/AKT signalling pathway
2019 · External reference
Design, synthesis and biological activity evaluation of novel scopoletin-NO donor derivatives against MCF-7 human breast cancer in vitro and in vivo
10.1016/j.ejmech.2021.113701 · 2021 · External reference
Novel Scopoletin Derivatives Kill Cancer Cells by Inducing Mitochondrial Depolarization and Apoptosis
10.2174/1871520621666201207094416 · 2021 · External reference
Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi
10.1055/s-2006-947165 · 2006 · External reference
Anticancer activity of botanical compounds in ancient fermented beverages (review)
10.3892/ijo_00000647 · 2010 · External reference
Molecular interaction studies using microscale thermophoresis
10.1089/adt.2011.0380 · 2011 · External reference
Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions
10.1016/j.ymeth.2012.12.005 · 2013 · External reference
Microscale Thermophoresis (MST) to Detect the Interaction Between Purified Protein and Small Molecule
10.1007/978-1-0716-0954-5_17 · 2021 · External reference
Protein-binding assays in biological liquids using microscale thermophoresis
10.1038/ncomms1093 · 2010 · External reference
Bioactive ingredients obtained from Cortex Fraxini impair interactions between FAS and GPI
10.1016/j.freeradbiomed.2019.11.022 · 2020 · External reference
Sample size calculations
10.1159/000322830 · 2011 · External reference
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
10.1093/nar/gkac194 · 2022 · External reference
The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets
10.1093/nar/gkaa1074 · 2021 · External reference
Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data
10.1021/acs.jproteome.8b00702 · 2019 · External reference
Scopolin obtained from Smilax china L. against hepatocellular carcinoma by inhibiting glycolysis: A network pharmacology and experimental study
10.1016/j.jep.2022.115469 · 2022 · External reference
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression
10.1080/09553002.2019.1589653 · 2019 · External reference
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells
10.2337/diab.45.9.1238 · 1996 · External reference
Tumor-associated macrophage interleukin-β promotes glycerol-3-phosphate dehydrogenase activation, glycolysis and tumorigenesis in glioma cells
10.1111/cas.14408 · 2020 · External reference
Human haptoglobin contributes to breast cancer oncogenesis through glycolytic activity modulation
2020 · External reference
Phosphoglucose isomerase gene expression as a prognostic biomarker of gastric cancer
10.21147/j.issn.1000-9604.2019.05.07 · 2019 · External reference
GPI Is a Prognostic Biomarker and Correlates With Immune Infiltrates in Lung Adenocarcinoma
10.3389/fonc.2021.752642 · 2021 · External reference
Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women
10.1371/journal.pone.0005606 · 2009 · External reference
Regulation and function of the human HSP90AA1 gene
10.1016/j.gene.2015.06.018 · 2015 · External reference
Immunotherapy for human cancer using heat shock protein-peptide complexes
10.1007/s11912-005-0035-8 · 2005 · External reference
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
10.1016/s0092-8674(00)80314-1 · 1997 · External reference
Effects of Intermittent Hypoxia on Expression of Glucose Metabolism Genes in MCF7 Breast Cancer Cell Line
10.2174/1568009619666191116095847 · 2020 · External reference
Crystal structure of Thermus caldophilus phosphoglycerate kinase in the open conformation
10.1016/j.bbrc.2006.09.151 · 2006 · External reference
Kinetic Microscale Thermophoresis for Simultaneous Measurement of Binding Affinity and Kinetics
10.1002/anie.202101261 · 2021 · External reference
