Research graph
References from Glycemic load impacts the response of acquired resistance in breast cancer cells to chemotherapeutic drugs in vitro. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2021 · External reference
Metabolic interactions in the tumor microenvironment
10.1016/j.tcb.2017.06.003 · 2017 · External reference
Diabetes as a risk factor for breast cancer
2020 · External reference
Mammary adipose tissue control of breast cancer progression: Impact of obesity and diabetes
10.3389/fonc.2020.01554 · 2020 · External reference
Unresolved reference
2020 · External reference
Metformin increases survival in hormone receptor-positive, HER2-positive breast cancer patients with diabetes
2015 · External reference
Association of metformin use and cancer incidence: a systematic review and meta-analysis
2024 · External reference
Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications
2020 · External reference
Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics
2004 · External reference
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
10.4161/cc.9.16.12553 · 2010 · External reference
Diabetes and cancer: cancer should be screened in routine diabetes assessment
10.4093/dmj.2019.0177 · 2019 · External reference
The effects of diabetes and glycemic control on cancer outcomes in individuals with metastatic breast cancer
10.1210/clinem/dgac375 · 2022 · External reference
Type 2 Diabetes and all-cause mortality among Spanish women with breast cancer
10.1007/s10552-021-01526-x · 2022 · External reference
Synergistic effect of antimetabolic and chemotherapy drugs in triple-negative breast cancer
10.1016/j.biopha.2022.112844 · 2022 · External reference
Drug resistance mediated by cellular stress response to the microenvironment of solid tumors
1999 · External reference
Challenges and perspectives in the treatment of diabetes associated breast cancer
10.1016/j.ctrv.2018.08.004 · 2018 · External reference
Hyperglycemia and chemoresistance in breast cancer: from cellular mechanisms to treatment response
10.3389/fonc.2021.628359 · 2021 · External reference
The glucose‐deprivation network counteracts lapatinib‐induced toxicity in resistant ErbB2‐positive breast cancer cells
10.1038/msb.2012.25 · 2012 · External reference
Expressions of IGF-1R and Ki-67 in breast cancer patients with diabetes mellitus and an analysis of biological characteristics
2022 · External reference
Immunohistochemical analysis of P-glycoprotein expression correlated with chemotherapy resistance in locally advanced breast cancer
10.1016/0046-8177(90)90046-8 · 1990 · External reference
Tumor microenvironment and cancer therapy resistance
10.1016/j.canlet.2015.07.044 · 2016 · External reference
editor Clinical experience with pemetrexed in breast cancer
2006 · External reference
Modeling Neoadjuvant chemotherapy resistance in vitro increased NRP‐1 and HER2 expression and converted MCF7 breast cancer subtype
10.1111/bph.14966 · 2020 · External reference
Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines
10.1186/1471-2407-13-63 · 2013 · External reference
Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges
10.1016/j.biopha.2023.114643 · 2023 · External reference
Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs
10.1111/j.1349-7006.2011.01880.x · 2011 · External reference
The biochemical and molecular mechanisms involved in the role of tumor micro-environment stress in development of drug resistance
10.1016/j.bbagen.2019.06.007 · 2019 · External reference
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
10.1126/science.1174229 · 2009 · External reference
Breast cancer treatment: a review
10.1001/jama.2018.19323 · 2019 · External reference
Cyclophosphamide, epirubicin, and fluorouracil versus dose-dense epirubicin and cyclophosphamide followed by paclitaxel versus doxorubicin and cyclophosphamide followed by paclitaxel in node-positive or high-risk node-negative breast cancer
10.1200/jco.2009.22.1077 · 2010 · External reference
Higher glucose enhances breast cancer cell aggressiveness
10.1080/01635581.2019.1654527 · 2020 · External reference
Glucose promotes breast cancer aggression and reduces metformin efficacy
10.4161/cc.26641 · 2013 · External reference
TP53 mutation hits energy metabolism and increases glycolysis in breast cancer
10.18632/oncotarget.11594 · 2016 · External reference
10.1038/sj.neo.7900101 · 2000 · Admitted local publication
Neoadjuvant chemotherapy alters neuropilin-1, PlGF, and SNAI1 expression levels and predicts breast cancer patients response
10.3389/fonc.2019.00323 · 2019 · External reference
Neuropilin-1 Knockout and Rescue Confirms Its Role to Promote Metastasis in MDA-MB-231 Breast Cancer Cells
10.3390/ijms24097792 · 2023 · External reference
Optical imaging of metabolism in HER2 overexpressing breast cancer cells
10.1364/boe.3.000075 · 2012 · External reference
The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria
10.1515/hsz-2016-0130 · 2016 · External reference
Role of the NF-kB pathway in the pathogenesis of human disease states
10.2174/1566524013363816 · 2001 · External reference
Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy
10.1016/j.canlet.2008.05.045 · 2009 · External reference
Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells
10.4161/cc.27728 · 2014 · External reference
Insulin-like growth factor signaling in pediatric sarcomas
2011 · External reference
Disrupting insulin-like growth factor signaling as a potential cancer therapy
10.1158/1535-7163.mct-06-0080 · 2007 · External reference
Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts
10.1158/1535-7163.mct-11-1003 · 2012 · External reference
Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27 Kip1 or p21 Cip1
2008 · External reference
