Research graph
References from Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
How neuroinflammation contributes to neurodegeneration
10.1126/science.aag2590 · 2016 · External reference
Microglia in Alzheimer’s disease
10.1172/jci90606 · 2017 · External reference
Intact cannabinoid CB1 receptors in the Alzheimer’s disease cortex
10.1016/j.neuint.2010.10.010 · 2010 · External reference
In vivo type 1 cannabinoid receptor availability in Alzheimer’s disease.
10.1016/j.euroneuro.2013.10.002 · 2014 · External reference
Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer’s disease brains
10.1523/jneurosci.23-35-11136.2003 · 2003 · External reference
The Acute Activation of the CB1 Receptor in the Hippocampus Decreases Neurotoxicity and Prevents Spatial Memory Impairment in Rats Lesioned with beta-Amyloid 25–35
10.1016/j.neuroscience.2019.08.001 · 2019 · External reference
Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats
10.1016/j.lfs.2018.11.058 · 2019 · External reference
Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.
10.1371/journal.pone.0049057 · 2012 · External reference
Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders.
10.2174/187152710793361568 · 2010 · External reference
The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
10.1093/brain/awm160 · 2007 · External reference
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury.
10.1038/35097089 · 2001 · External reference
Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation
10.1074/jbc.m800524200 · 2008 · External reference
Elevation of Plasma 2-Arachidonoylglycerol Levels in Alzheimer’s Disease Patients as a Potential Protective Mechanism against Neurodegenerative Decline
10.3233/jad-142349 · 2015 · External reference
The Role of Eicosanoids in Alzheimer’s Disease.
10.3390/ijerph16142560 · 2019 · External reference
Imaging neuroinflammation in Alzheimer’s disease with radiolabeled arachidonic acid and PET
10.2967/jnumed.107.049619 · 2008 · External reference
Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling
10.1016/j.pharmthera.2017.02.033 · 2017 · External reference
Brain monoglyceride lipase participating in endocannabinoid inactivation
10.1073/pnas.152334899 · 2002 · External reference
Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
10.1016/j.chembiol.2009.05.009 · 2009 · External reference
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
10.1126/science.1209200 · 2011 · External reference
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety
10.1021/acs.jmedchem.1c00432 · 2021 · External reference
Microglial and astrocytic cell responses in the rat hippocampus after an intracerebroventricular kainic acid injection
10.1006/exnr.1993.1089 · 1993 · External reference
Glycyrrhizin attenuates kainic Acid-induced neuronal cell death in the mouse hippocampus
10.5607/en.2013.22.2.107 · 2013 · External reference
Design, Synthesis, and Evaluation of (4 R)-1-3-[2-((18)F)Fluoro-4-methylpyridin-3-yl]phenyl-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([(18)F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase.
10.1021/acs.jmedchem.8b01576 · 2019 · External reference
Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors
10.1021/acs.jmedchem.8b00824 · 2018 · External reference
FTY720 attenuates excitotoxicity and neuroinflammation.
10.1186/s12974-015-0308-6 · 2015 · External reference
voom: Precision weights unlock linear model analysis tools for RNA-seq read counts
10.1186/gb-2014-15-2-r29 · 2014 · External reference
A scaling normalization method for differential expression analysis of RNA-seq data
10.1186/gb-2010-11-3-r25 · 2010 · External reference
Brain lesions and water-maze learning deficits after systemic administration of kainic acid to adult rats
10.1016/0006-8993(94)90376-x · 1994 · External reference
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
10.1124/mol.110.068304 · 2010 · External reference
CB1 cannabinoid receptors and on-demand defense against excitotoxicity
10.1126/science.1088208 · 2003 · External reference
Selective activation of cannabinoid receptor-2 reduces neuroinflammation after traumatic brain injury via alternative macrophage polarization
10.1016/j.bbi.2017.10.021 · 2018 · External reference
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet
10.1111/epi.13950 · 2018 · External reference
Post-treatment, but not pre-treatment, with the selective cyclooxygenase-2 inhibitor celecoxib markedly enhances functional recovery from kainic acid-induced neurodegeneration
10.1016/j.neuroscience.2004.01.045 · 2004 · External reference
RNA sequencing analysis of cortex and hippocampus in a kainic acid rat model of temporal lobe epilepsy to identify mechanisms and therapeutic targets related to inflammation, immunity and cognition
10.1016/j.intimp.2020.106825 · 2020 · External reference
Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus
10.1016/j.brainres.2007.08.092 · 2007 · External reference
Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease
10.1016/j.neurobiolaging.2005.10.007 · 2006 · External reference
Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
10.1186/s12974-018-1166-9 · 2018 · External reference
Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.
10.1016/j.yebeh.2016.11.006 · 2017 · External reference
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
10.1038/nchembio.925 · 2012 · External reference
Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized
10.1002/mds.28681 · 2021 · External reference
