Research graph
References from The SARS-CoV-2 ORF6 protein inhibits nuclear export of mRNA and spliceosomal U snRNA. Local targets link to admitted publications; unresolved targets remain external evidence.
A pneumonia outbreak associated with a new coronavirus of probable bat origin
10.1038/s41586-020-2012-7 · 2020 · External reference
Omicron variant of SARS-CoV-2: Genomics, transmissibility, and responses to current COVID-19 vaccines
10.1002/jmv.27588 · 2022 · External reference
The Deltacron conundrum: Its origin and potential health risks
10.1002/jmv.27990 · 2022 · External reference
Activation and evasion of type I interferon responses by SARS-CoV-2.
10.1038/s41467-020-17665-9 · 2020 · External reference
The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway
10.1016/j.virusres.2020.198074 · 2020 · External reference
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
10.1073/pnas.2016650117 · 2020 · External reference
Evasion of Type I Interferon by SARS-CoV-2
10.1016/j.celrep.2020.108234 · 2020 · External reference
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
10.1080/22221751.2020.1780953 · 2020 · External reference
Sarbecovirus ORF6 proteins hamper induction of interferon signaling
10.1016/j.celrep.2021.108916 · 2021 · External reference
Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.
10.1186/s13578-021-00568-7 · 2021 · External reference
RNA Export through the NPC in Eukaryotes.
10.3390/genes6010124 · 2015 · External reference
Exporting RNA from the nucleus to the cytoplasm
10.1038/nrm2255 · 2007 · External reference
TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
10.1016/s1097-2765(00)80065-9 · 1998 · External reference
The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
10.1093/emboj/18.9.2593 · 1999 · External reference
Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
10.1128/mcb.18.11.6826 · 1998 · External reference
Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.
10.1093/emboj/16.11.3256 · 1997 · External reference
Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p
10.1128/mcb.21.10.3405-3415.2001 · 2001 · External reference
Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit
10.1083/jcb.151.5.1057 · 2000 · External reference
CRM1 is an export receptor for leucine-rich nuclear export signals
10.1016/s0092-8674(00)80371-2 · 1997 · External reference
Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae
10.1534/genetics.106.062117 · 2006 · External reference
Late cytoplasmic maturation of the small ribosomal subunit requires RIO proteins in Saccharomyces cerevisiae
10.1128/mcb.23.6.2083-2095.2003 · 2003 · External reference
The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes.
10.1093/emboj/cdg121 · 2003 · External reference
CRM1-dependent, but not ARE-mediated, nuclear export of IFN-alpha1 mRNA
10.1242/jcs.01076 · 2004 · External reference
eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3’UTR
10.1083/jcb.200501019 · 2005 · External reference
Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-α 1 mRNA.
10.1007/s00795-010-0492-5 · 2010 · External reference
Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex.
10.1073/pnas.1113076108 · 2011 · External reference
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm
10.1093/emboj/cdf613 · 2002 · External reference
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.
10.1093/emboj/cdf620 · 2002 · External reference
The role of exportin-t in selective nuclear export of mature tRNAs
10.1093/emboj/17.24.7430 · 1998 · External reference
Identification of a nuclear export receptor for tRNA
10.1016/s0960-9822(98)70130-7 · 1998 · External reference
Identification of a tRNA-specific nuclear export receptor
10.1016/s1097-2765(00)80036-2 · 1998 · External reference
The structure of the nuclear pore complex
10.1146/annurev-biochem-060109-151030 · 2011 · External reference
RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains
10.1083/jcb.145.2.237 · 1999 · External reference
The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways
10.1083/jcb.136.2.241 · 1997 · External reference
Viral interactions with the nuclear transport machinery: discovering and disrupting pathways
10.1080/15216540500078608 · 2005 · External reference
Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98
10.1016/s1097-2765(00)00120-9 · 2000 · External reference
VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway
10.1016/j.molcel.2004.11.023 · 2005 · External reference
Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus
10.1126/science.276.5320.1845 · 1997 · External reference
Role of nucleoporin induction in releasing an mRNA nuclear export block
10.1126/science.1067861 · 2002 · External reference
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
10.1038/s41586-020-2286-9 · 2020 · External reference
SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98.
10.1128/mbio.00065-21 · 2021 · External reference
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export.
10.1371/journal.ppat.1010349 · 2022 · External reference
Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex
10.1016/j.bbrc.2020.11.115 · 2021 · External reference
Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export.
10.3389/fmolb.2021.813248 · 2021 · External reference
Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport.
10.1038/s41467-022-32489-5 · 2022 · External reference
Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA
10.1038/emboj.2009.5 · 2009 · External reference
Nuclear export of different classes of RNA is mediated by specific factors
10.1083/jcb.124.5.627 · 1994 · External reference
Analysis of RNA transport in Xenopus oocytes and mammalian cells
10.1016/b978-0-12-417160-2.00018-7 · 2014 · External reference
Monomethylated cap structures facilitate RNA export from the nucleus
10.1016/0092-8674(90)90292-m · 1990 · External reference
An abundant U6 snRNP found in germ cells and embryos of Xenopus laevis
10.1002/j.1460-2075.1989.tb08603.x · 1989 · External reference
Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 • Nup98).
10.1073/pnas.1409076111 · 2014 · External reference
Nanoscopic Elucidation of Spontaneous Self-Assembly of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Open Reading Frame 6 (ORF6) Protein.
10.1021/acs.jpclett.3c01440 · 2023 · External reference
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses
10.1016/j.cell.2020.10.004 · 2020 · External reference
SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis
10.1038/s41586-021-03610-3 · 2021 · External reference
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
10.7554/elife.11466 · 2015 · External reference
