Research graph
References from Unlocking vinpocetine’s oncostatic potential in early-stage hepatocellular carcinoma: A new approach to oncogenic modulation by a nootropic drug. Local targets link to admitted publications; unresolved targets remain external evidence.
Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells
10.1016/j.bioorg.2021.105329 · 2021 · External reference
Hepatocellular carcinoma
10.1038/s41572-020-00240-3 · 2021 · External reference
A Network-Guided Approach to Discover Phytochemical-Based Anticancer Therapy: Targeting MARK4 for Hepatocellular Carcinoma
10.3389/fonc.2022.914032 · 2022 · External reference
Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats
10.1155/2018/8058979 · 2018 · External reference
Hepatitis Virus and Hepatocellular Carcinoma: Recent Advances
10.3390/cancers15020533 · 2023 · External reference
Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma
2022 · External reference
Drug Treatment for Advanced Hepatocellular Carcinoma: First-Line and Beyond
10.3390/curroncol29080434 · 2022 · External reference
Hepatocellular Carcinoma: New Developments
10.1016/j.cld.2022.08.004 · 2023 · External reference
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC
10.1016/j.biopha.2019.108732 · 2019 · External reference
Systemic therapy of advanced hepatocellular carcinoma
10.2217/fon-2020-0758 · 2021 · External reference
AKT-AMPKα-mTOR-dependent HIF-1α Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma
2022 · External reference
Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer
10.1007/s00210-023-02511-8 · 2023 · External reference
Vinpocetine (A comprehensive profile)
10.1016/bs.podrm.2021.10.001 · 2022 · External reference
An update on vinpocetine: New discoveries and clinical implications
10.1016/j.ejphar.2017.11.041 · 2018 · External reference
Effect of vinpocetine (cognitol™) on cognitive performances of a nigerian population
10.4103/2141-9248.139368 · 2014 · External reference
Vinpocetine blockade of sodium channels inhibits the rise in sodium and calcium induced by 4-aminopyridine in synaptosomes
10.1016/j.neuint.2005.02.001 · 2005 · External reference
Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism
10.1073/pnas.0914414107 · 2010 · External reference
Vinpocetine as a potent antiinflammatory agent
10.1073/pnas.1005138107 · 2010 · External reference
Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches
2016 · External reference
NF-kB in Signaling Patterns and Its Temporal Dynamics Encode/Decode Human Diseases
10.3390/life12122012 · 2022 · External reference
NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
10.1128/mcb.19.9.5923 · 1999 · External reference
Vinpocetine inhibits breast cancer cells growth in vitro and in vivo
10.1007/s10495-012-0743-0 · 2012 · External reference
Enhanced anticancer activity by the combination of vinpocetine and sorafenib via PI3K/AKT/GSK-3β signaling axis in hepatocellular carcinoma cells
10.1097/cad.0000000000001056 · 2021 · External reference
Increase in tumor oxygenation and potentiation of radiation effects using pentoxifylline, vinpocetine and ticlopidine hydrochloride
10.1269/jrr.46.373 · 2005 · External reference
Vinpocetine inhibits NF-κB–dependent inflammation via an IKK-dependent but PDE-independent mechanism
10.1073/pnas.0914414107 · 2010 · External reference
Lactosylated Chitosan Nanoparticles Potentiate the Anticancer Effects of Telmisartan In Vitro and in a N-Nitrosodiethylamine-Induced Mice Model of Hepatocellular Carcinoma
10.1021/acs.molpharmaceut.3c00542 · 2023 · External reference
Linagliptin, a DPP-4 inhibitor, activates AMPK/FOXO3a and suppresses NFκB to mitigate the debilitating effects of diethylnitrosamine exposure in rat liver: Novel mechanistic insights
10.1096/fj.202302461rr · 2024 · External reference
Vinpocetine attenuates thioacetamide-induced liver fibrosis in rats
10.1177/0960327120947453 · 2021 · External reference
Vinpocetine attenuates MPTP-induced motor deficit and biochemical abnormalities in Wistar rats
10.1016/j.neuroscience.2014.12.008 · 2015 · External reference
Vinpocetine Mediates Therapeutic Activity Alone and in Combination with Chemotherapy in T-Cell Acute Lymphoblastic Leukemia
10.1182/blood-2023-190607 · 2023 · External reference
Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF–κB pathway and activation of Nrf2/ARE pathway in rats
10.1007/s11255-020-02485-z · 2020 · External reference
Vinpocetine ameliorates developmental hyperserotonemia induced behavioral and biochemical changes: role of neuronal function, inflammation, and oxidative stress
10.55782/ane-2022-004 · 2022 · External reference
Vinpocetine prevents haloperidol-induced cognitive and working memory deficits through attenuation of oxidative and nitrosative stress in mice
2020 · External reference
Effects of vinpocetine on atopic dermatitis after administration via three different routes in HR-1 hairless mice
2022 · External reference
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats
10.1016/j.neuro.2023.03.002 · 2023 · External reference
Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats
10.1016/j.lfs.2021.119506 · 2021 · External reference
Early ethanol exposure and vinpocetine treatment alter learning- and memory-related proteins in the rat hippocampus and prefrontal cortex
10.1002/jnr.23894 · 2017 · External reference
Vinpocetine, a PDE1 modulator, regulates markers of cerebral health, inflammation, and oxidative stress in a rat model of prenatal alcohol-induced experimental attention deficit hyperactivity disorder
10.1016/j.alcohol.2022.08.005 · 2022 · External reference
Vinpocetine mitigates proteinuria and podocytes injury in a rat model of diabetic nephropathy
10.1016/j.ejphar.2017.08.027 · 2017 · External reference
Blunting p38 MAPKα and ERK1/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-κB inactivation in mice intoxicated with carbon tetrachloride
10.1016/j.lfs.2021.120070 · 2021 · External reference
Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application
10.1016/j.biopha.2021.112455 · 2022 · External reference
Histological grading and staging of chronic hepatitis
10.1016/0168-8278(95)80226-6 · 1995 · External reference
A Novel Combination Therapy Using Rosuvastatin and Lactobacillus Combats Dextran Sodium Sulfate-Induced Colitis in High-Fat Diet-Fed Rats by Targeting the TXNIP/NLRP3 Interaction and Influencing Gut Microbiome Composition
10.3390/ph14040341 · 2021 · External reference
Hepatocellular carcinoma
10.1023/a:1008370324827 · 2001 · External reference
A global view of hepatocellular carcinoma: trends, risk, prevention and management
10.1038/s41575-019-0186-y · 2019 · External reference
Combination of Vitamin C and Curcumin Safeguards Against Methotrexate-Induced Acute Liver Injury in Mice by Synergistic Antioxidant Effects
10.3389/fmed.2022.866343 · 2022 · External reference
Recent progress in treatment of hepatocellular carcinoma
2020 · External reference
Sorafenib: Experience and Better Manage-ment of Side Effects Improve Overall Survival in Hepatocellular Carcinoma Patients: A Real-Life Retrospective Analysis
10.1159/000497161 · 2019 · External reference
DEN-Induced Rat Model Reproduces Key Features of Human Hepatocellular Carcinoma
10.3390/cancers13194981 · 2021 · External reference
Two‐dimensional differential gel electrophoresis/analysis of diethylnitrosamine induced rat hepatocellular carcinoma
10.1002/ijc.23464 · 2008 · External reference
The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver
10.1016/j.ejca.2007.05.005 · 2007 · External reference
Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice
10.1155/2018/9472939 · 2018 · External reference
Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target
10.1186/s13046-021-02062-x · 2021 · External reference
Knockout of ASPP2 promotes DEN-induced hepatocarcinogenesis via the NF-κB pathway in mice
10.1038/s41417-021-00300-0 · 2022 · External reference
Unresolved reference
2022 · External reference
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
10.1016/j.cell.2005.04.014 · 2005 · External reference
VEGF expression in human macrophages is NF-κB-dependent: studies using adenoviruses expressing the endogenous NF-κB inhibitor IκBα and a kinase-defective form of the IκB kinase 2
10.1242/jcs.00286 · 2003 · External reference
PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation
10.1186/s12943-015-0490-2 · 2016 · External reference
Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis
10.1016/j.biopha.2022.113409 · 2022 · External reference
Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: A novel approach for filling an unmet medical need
10.1016/j.biopha.2022.112723 · 2022 · External reference
Caspase-1–Independent IL-1 Release Mediates Blister Formation in Autoantibody-Induced Tissue Injury through Modulation of Endothelial Adhesion Molecules
10.4049/jimmunol.1402688 · 2015 · External reference
Role of liver ICAM-1 in metastasis
10.3892/ol.2017.6700 · 2017 · External reference
Regulatory T cells promote glioma cell stemness through TGF-β-NF-κB-IL6-STAT3 signaling
10.1007/s00262-021-02872-0 · 2021 · External reference
Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within
2022 · External reference
Alvespimycin Exhibits Potential Anti-TGF-β Signaling in the Setting of a Proteasome Activator in Rats with Bleomycin-Induced Pulmonary Fibrosis: A Promising Novel Approach
10.3390/ph16081123 · 2023 · External reference
MCP-1: Function, regulation, and involvement in disease
10.1016/j.intimp.2021.107598 · 2021 · External reference
Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis
10.15252/embj.201592789 · 2016 · External reference
What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?
10.3389/fcell.2019.00154 · 2019 · External reference
Carbocisteine as a Modulator of Nrf2/HO-1 and NFκB Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis
10.3389/fphar.2022.887233 · 2022 · External reference
Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis
10.1083/jcb.202201159 · 2022 · External reference
Ambroxol, a mucolytic agent, boosts HO-1, suppresses NF-κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for treating ulcerative colitis
10.1096/fj.202200749r · 2022 · External reference
The Supportive Role of NSC328382, a P2X7R Antagonist, in Enhancing the Inhibitory Effect of CRID3 on NLRP3 Inflammasome Activation in Rats with Dextran Sodium Sulfate-Induced Colitis
10.2147/jir.s315938 · 2021 · External reference
Zolmitriptan attenuates hepatocellular carcinoma via activation of caspase mediated apoptosis
10.1016/j.cbi.2019.05.033 · 2019 · External reference
Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration
10.1074/jbc.m112.419788 · 2013 · External reference
Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial-mesenchymal transition
10.2147/ott.s168317 · 2018 · External reference
STAT3 Target Genes Relevant to Human Cancers
10.3390/cancers6020897 · 2014 · External reference
Role of Matrix Metalloproteinases in Angiogenesis and Cancer
10.3389/fonc.2019.01370 · 2019 · External reference
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss
10.1016/j.biopha.2019.109769 · 2020 · External reference
Vinpocetine alleviates intestinal ischemia/reperfusion injury and enhances M2 macrophage polarization in rats: Role of SIRT1/SOCS3/STAT3 signaling pathway
10.1016/j.intimp.2023.110654 · 2023 · External reference
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
10.2147/hp.s93413 · 2015 · External reference
Hypoxia-induced angiogenesis: good and evil
10.1177/1947601911423654 · 2011 · External reference
Basic FGF augments hypoxia induced HIF‐1‐alpha expression and VEGF release in T47D breast cancer cells
10.1080/00313020701444549 · 2007 · External reference
Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells
10.1161/01.res.77.3.638 · 1995 · External reference
STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells
10.1096/fj.04-3099fje · 2005 · External reference
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose
10.1186/s12967-021-02946-8 · 2021 · External reference