Research graph
References from Classical cadherins evolutionary constraints in primates is associated with their expression in the central nervous system. Local targets link to admitted publications; unresolved targets remain external evidence.
Cadherins in brain morphogenesis and wiring
10.1152/physrev.00014.2011 · 2012 · External reference
Regulation of cadherin-mediated adhesion in morphogenesis
10.1038/nrm1699 · 2005 · External reference
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members
10.1006/jmbi.2000.3777 · 2000 · External reference
Evolution: structural and functional diversity of cadherin at the adherens junction
10.1083/jcb.201008173 · 2011 · External reference
Cadherin cell adhesion receptors as a morphogenetic regulator
10.1126/science.2006419 · 1991 · External reference
Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/beta-catenin complex
10.1073/pnas.1120685109 · 2012 · External reference
Diverse evolutionary paths to cell adhesion
10.1016/j.tcb.2010.08.002 · 2010 · External reference
Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective
10.1101/cshperspect.a029207 · 2018 · External reference
Structural basis of cell-cell adhesion by cadherins
10.1038/374327a0 · 1995 · External reference
Considerations on the folding topology and evolutionary origin of cadherin domains
10.1073/pnas.92.15.6793 · 1995 · External reference
Structure and biochemistry of cadherins and catenins
10.1101/cshperspect.a003053 · 2009 · External reference
Molecular evolution of the cadherin superfamily
10.1016/j.biocel.2008.09.027 · 2009 · External reference
Structure and mechanism of cadherins and catenins in cell-cell contacts
10.1146/annurev.cellbio.22.010305.104241 · 2007 · External reference
Classical cadherins
10.1016/s1043-4682(10)80011-x · 1992 · External reference
Identification of a cadherin cell adhesion recognition sequence
10.1016/0012-1606(90)90290-y · 1990 · External reference
Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling
10.1083/jcb.128.5.959 · 1995 · External reference
Proprotein cleavage of E-cadherin by furin in baculovirus over-expression system: potential role of other convertases in mammalian cells
10.1016/s0014-5793(98)01330-1 · 1998 · External reference
Homophilic adhesion by cadherins
10.1016/s0959-440x(99)80038-4 · 1999 · External reference
Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition
10.1016/j.cell.2020.04.010 · 2020 · External reference
Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling
10.1038/nrm3802 · 2014 · External reference
C-cadherin ectodomain structure and implications for cell adhesion mechanisms
10.1126/science.1071559 · 2002 · External reference
Two-step adhesive binding by classical cadherins
10.1038/nsmb.1784 · 2010 · External reference
Type II cadherin ectodomain structures: implications for classical cadherin specificity
10.1016/j.cell.2005.12.046 · 2006 · External reference
Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior
10.1016/j.celrep.2018.04.012 · 2018 · External reference
Structure-function analysis of cell adhesion by neural (N-) cadherin
10.1016/s0896-6273(00)80496-1 · 1998 · External reference
Linking molecular affinity and cellular specificity in cadherin-mediated adhesion
10.1073/pnas.0905349106 · 2009 · External reference
Structural and energetic determinants of adhesive binding specificity in type I cadherins
10.1073/pnas.1416737111 · 2014 · External reference
T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region
10.1016/0896-6273(91)90291-7 · 1991 · External reference
T-cadherin structures reveal a novel adhesive binding mechanism
10.1038/nsmb.1781 · 2010 · External reference
Cadherins in neuronal morphogenesis and function
2008 · External reference
Regulation of motor neuron pool sorting by differential expression of type II cadherins
10.1016/s0092-8674(02)00695-5 · 2002 · External reference
Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness
10.1038/s42003-020-01297-2 · 2020 · External reference
Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation
10.1523/jneurosci.0243-07.2007 · 2007 · External reference
Type II Cadherins Guide Assembly of a Direction-Selective Retinal Circuit
10.1016/j.cell.2014.06.047 · 2014 · External reference
Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold
10.1016/j.neuron.2018.08.019 · 2018 · External reference
Evolution and diversity of cadherins and catenins
10.1016/j.yexcr.2017.03.001 · 2017 · External reference
Evolution of the "classical" cadherin family of cell adhesion molecules in vertebrates
10.1093/oxfordjournals.molbev.a026017 · 1998 · External reference
A composite estimate of primate phylogeny
10.1098/rstb.1995.0078 · 1995 · External reference
Guidelines for human gene nomenclature
10.1038/s41588-020-0669-3 · 2020 · External reference
MUSCLE: multiple sequence alignment with high accuracy and high throughput
10.1093/nar/gkh340 · 2004 · External reference
MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms
10.1093/molbev/msy096 · 2018 · External reference
MEGA11: Molecular Evolutionary Genetics Analysis Version 11
10.1093/molbev/msab120 · 2021 · External reference
Molecular Evolutionary Genetics Analysis (MEGA) for macOS
10.1093/molbev/msz312 · 2020 · External reference
10.1093/oso/9780195135848.001.0001
10.1093/oso/9780195135848.001.0001 · 2000 · External reference
Impact of extracellularity on the evolutionary rate of mammalian proteins
10.1093/gbe/evp058 · 2010 · External reference
The GTEx Consortium atlas of genetic regulatory effects across human tissues
10.1126/science.aaz1776 · 2020 · External reference
A study on the use of non-parametric tests for analyzing the evolutionary algorithms’ behaviour: a case study on the CEC’2005 Special Session on Real Parameter Optimization
10.1007/s10732-008-9080-4 · 2009 · External reference
Performance of nonparametric multiple comparison tests under heteroscedasticity, dependency, and skewed error distribution
10.1080/03610918.2016.1146761 · 2017 · External reference
Estimating synonymous and nonsynonymous substitution rates under realistic evolutionary models
10.1093/oxfordjournals.molbev.a026236 · 2000 · External reference
Molecular signatures of natural selection
10.1146/annurev.genet.39.073003.112420 · 2005 · External reference
Secreted Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation
2017 · External reference
N-glycoproteins exhibit a positive expression level-evolutionary rate correlation
10.1111/jeb.13420 · 2019 · External reference
What amino acid properties affect protein evolution?
10.1007/pl00006412 · 1998 · External reference
Determinants of substitution rates in mammalian genes: expression pattern affects selection intensity but not mutation rate
10.1093/oxfordjournals.molbev.a026239 · 2000 · External reference
An analysis of determinants of amino acids substitution rates in bacterial proteins
10.1093/molbev/msh004 · 2004 · External reference
Evolutionary significance of gene expression divergence
10.1016/j.gene.2004.11.034 · 2005 · External reference
Mammalian housekeeping genes evolve more slowly than tissue-specific genes
10.1093/molbev/msh010 · 2004 · External reference
A single determinant dominates the rate of yeast protein evolution
10.1093/molbev/msj038 · 2006 · External reference
Highly expressed genes in yeast evolve slowly
10.1093/genetics/158.2.927 · 2001 · External reference
Why highly expressed proteins evolve slowly
10.1073/pnas.0504070102 · 2005 · External reference
Impact of translational error-induced and error-free misfolding on the rate of protein evolution
10.1038/msb.2010.78 · 2010 · External reference
Protein misinteraction avoidance causes highly expressed proteins to evolve slowly
2012 · External reference
Analysis of spatial-temporal gene expression patterns reveals dynamics and regionalization in developing mouse brain
10.1038/srep19274 · 2016 · External reference
An anatomic gene expression atlas of the adult mouse brain
10.1038/nn.2281 · 2009 · External reference
The mutational constraint spectrum quantified from variation in 141,456 humans
10.1038/s41586-020-2308-7 · 2020 · External reference
The unicellular ancestry of animal development
10.1016/j.devcel.2004.08.010 · 2004 · External reference
The premetazoan ancestry of cadherins
10.1126/science.1151084 · 2008 · External reference
Evolution of key cell signaling and adhesion protein families predates animal origins
10.1126/science.1083853 · 2003 · External reference
Unresolved reference
2000 · External reference
Selective synaptic cadherin expression by traced neurons of the chicken visual system
10.1016/j.neuroscience.2004.05.023 · 2004 · External reference
Cadherins in the developing central nervous system: an adhesive code for segmental and functional subdivisions
10.1006/dbio.1996.0315 · 1996 · External reference
The cadherin superfamily in neuronal connections and interactions
10.1038/nrn2043 · 2007 · External reference
Synaptic Specificity, Recognition Molecules, and Assembly of Neural Circuits
10.1016/j.cell.2020.05.046 · 2020 · External reference
N-cadherin regulates primary motor axon growth and branching during zebrafish embryonic development
10.1002/cne.22602 · 2011 · External reference
Developmental defects in mouse embryos lacking N-cadherin
10.1006/dbio.1996.8443 · 1997 · External reference
E-cadherin null mutant embryos fail to form a trophectoderm epithelium
10.1073/pnas.91.17.8263 · 1994 · External reference
Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm
10.1242/dev.02722 · 2007 · External reference
Precocious mammary gland development in P-cadherin-deficient mice
10.1083/jcb.139.4.1025 · 1997 · External reference
A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation
10.1016/s0896-6273(00)80497-3 · 1998 · External reference
Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation
10.1016/s0896-6273(00)00100-8 · 2000 · External reference
N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons
10.1523/jneurosci.1013-06.2006 · 2006 · External reference
N-cadherin induces partial differentiation of cholinergic presynaptic terminals in heterologous cultures of brainstem neurons and CHO cells
10.3389/fnsyn.2012.00006 · 2012 · External reference
A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins
10.1016/s0896-6273(00)80175-0 · 1996 · External reference
The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones
10.1083/jcb.135.3.767 · 1996 · External reference
Neural (N)-cadherin at developing thalamocortical synapses provides an adhesion mechanism for the formation of somatopically organized connections
10.1002/(sici)1096-9861(19990517)407:4<453::aid-cne1>3.0.co;2-4 · 1999 · External reference
Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1
2005 · External reference
Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway
10.1002/hipo.20395 · 2008 · External reference
Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation
10.3389/fnmol.2018.00142 · 2018 · External reference
The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos
10.1016/0896-6273(90)90108-r · 1990 · External reference
Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos
10.1242/dev.110.1.97 · 1990 · External reference
Genetic dissection of cadherin function during nephrogenesis
10.1128/mcb.22.5.1474-1487.2002 · 2002 · External reference
Multiple cadherin extracellular repeats mediate homophilic binding and adhesion
10.1083/jcb.200103143 · 2001 · External reference
N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration
2019 · External reference
De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects
10.1016/j.ajhg.2019.09.005 · 2019 · External reference
Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse
10.3389/fnmol.2021.633719 · 2021 · External reference
The cellular basis of tissue separation
10.1242/dev.090332 · 2014 · External reference
Neuronal Circuits Are Subdivided by Differential Expression of Type-II Classic Cadherins in Postnatal Mouse Brains
10.1006/mcne.1997.0626 · 1997 · External reference
Many paths to synaptic specificity
10.1146/annurev.cellbio.24.110707.175402 · 2009 · External reference
Eye smarter than scientists believed: neural computations in circuits of the retina
10.1016/j.neuron.2009.12.009 · 2010 · External reference
Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus
10.1016/j.neuron.2017.09.009 · 2017 · External reference
Cadherin-9 regulates synapse-specific differentiation in the developing hippocampus
10.1016/j.neuron.2011.06.019 · 2011 · External reference
Common genetic variants on 5p14.1 associate with autism spectrum disorders
10.1038/nature07999 · 2009 · External reference
Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability
10.1136/jmg.2010.079426 · 2011 · External reference
Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder
10.1097/ypg.0b013e32834915c2 · 2011 · External reference
Autism meets schizophrenia via cadherin pathway
10.1016/j.schres.2009.09.031 · 2010 · External reference
Whole-genome association study of bipolar disorder
10.1038/sj.mp.4002151 · 2008 · External reference
Replication of GWAS of bipolar disorder: association of SNPs near CDH7 with bipolar disorder and visual processing
10.1038/mp.2009.86 · 2010 · External reference
Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16
10.1007/s00439-010-0899-z · 2011 · External reference
Genome-wide association studies in ADHD
10.1007/s00439-009-0663-4 · 2009 · External reference
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism
10.1016/j.neuron.2011.05.002 · 2011 · External reference
Evolution of synapse complexity and diversity
10.1146/annurev-neuro-062111-150433 · 2012 · External reference
The human postsynaptic density shares conserved elements with proteomes of unicellular eukaryotes and prokaryotes
2011 · External reference
Evolutionary expansion and anatomical specialization of synapse proteome complexity
10.1038/nn.2135 · 2008 · External reference
Fine structure of synaptogenesis in the vertebrate central nervous system
10.1002/syn.890030312 · 1989 · External reference
