Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Advantages of statin usage in preventing fractures for men over 50 in the United States: National Health and Nutrition Examination Survey. Local targets link to admitted publications; unresolved targets remain external evidence.
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
10.1016/s0140-6736(05)67394-1 · 2005 · External reference
Stimulation of bone formation in vitro and in rodents by statins
10.1126/science.286.5446.1946 · 1999 · External reference
Influence of Cholesterol on the Regulation of Osteoblast Function.
10.3390/metabo13040578 · 2023 · External reference
Osteoporosis Entwined with Cardiovascular Disease: The Implication of Osteoprotegerin and the Example of Statins
10.2174/0929867327666200123151132 · 2021 · External reference
Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women
10.1016/s0140-6736(00)02400-4 · 2000 · External reference
Statin use and fracture risk: study of a US veterans population
10.1001/archinte.165.17.2007 · 2005 · External reference
HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients
10.1001/jama.283.24.3211 · 2000 · External reference
HMG-CoA reductase inhibitors and the risk of fractures
10.1001/jama.283.24.3205 · 2000 · External reference
Statins and hip fracture prevention—a population based cohort study in women.
10.1371/journal.pone.0048095 · 2012 · External reference
Simvastatin increases bone mineral density in hypercholesterolemic postmenopausal women
10.1016/j.metabol.2004.01.010 · 2004 · External reference
Oral statins and increased bone-mineral density in postmenopausal women
10.1016/s0140-6736(00)02408-9 · 2000 · External reference
HMG-CoA reductase inhibitors (statins) and bone mineral density: a meta-analysis.
10.1016/j.bone.2013.01.044 · 2013 · External reference
Hip fracture risk in statin users—a population-based Danish case-control study.
10.1007/s00198-003-1568-z · 2004 · External reference
Use of statins and risk of fractures
10.1001/jama.285.14.1850 · 2001 · External reference
Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women’s Health Initiative Observational Study
10.7326/0003-4819-139-2-200307150-00009 · 2003 · External reference
Lack of positive correlation between statin use and bone mineral density in Japanese subjects with type 2 diabetes
10.1001/archinte.160.18.2865 · 2000 · External reference
Diagnosis of osteoporosis in statin-treated patients is dose-dependent
10.1136/annrheumdis-2019-215714 · 2019 · External reference
Short-term effects of pitavastatin on biochemical markers of bone turnover in patients with hypercholesterolemia
10.2169/internalmedicine.46.0419 · 2007 · External reference
The effect of fluvastatin on parameters of bone remodeling
10.1007/s001980170106 · 2001 · External reference
Statin drugs and the risk of fracture
2000 · External reference
Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomized controlled trial
10.1016/s0140-6736(00)04042-3 · 2001 · External reference
Statin therapy and risk of fracture results from the JUPITER randomized clinical trial
10.1001/jamainternmed.2014.6388 · 2015 · External reference
Follow-up study of patients randomized in the Scandinavian simvastatin survival study (4S) of cholesterol lowering.
10.1016/s0002-9149(00)00910-3 · 2000 · External reference
Statins and fracture risk. A systematic review.
10.1002/pds.1363 · 2007 · External reference
Hydroxymethylglutaryl-coenzyme A reductase inhibitors and osteoporosis: a meta-analysis.
10.1007/s00198-004-1793-0 · 2005 · External reference
Effects of Statins on Relative Risk of Fractures for Older Adults: An Updated Systematic Review With Meta-Analysis.
2019 · External reference
Efficacy of statins for osteoporosis: a systematic review and meta-analysis.
10.1007/s00198-016-3844-8 · 2017 · External reference
Effects of Statins on Bone Mineral Density and Fracture Risk: A PRISMA-compliant Systematic Review and Meta-Analysis.
10.1097/md.0000000000003042 · 2016 · External reference
Statin use and risk of fracture: a meta-analysis.
2015 · External reference
Effects of statins on bone mineral density: A meta-analysis of clinical studies
10.1016/j.bone.2007.02.019 · 2007 · External reference
Principles and Practice of Structural Equation Modelling
2011 · External reference
Are blood lipids risk factors for fracture? Integrative evidence from instrumental variable causal inference and mediation analysis using genetic data
10.1016/j.bone.2019.115174 · 2020 · External reference
Mediating effect analysis of categorical variables
2017 · External reference
Mediation effect analysis: principle, procedure, Bootstrap method and its application
2013 · External reference
Regulation of cholesterol homeostasis in osteoporosis mechanisms and therapeutics
10.1042/cs20220752 · 2023 · External reference
Oxidized low density lipoprotein enhanced RANKL expression in human osteoblast-like cells. Involvement of ERK, NFkappaB and NFAT
10.1016/j.bbadis.2013.05.033 · 2013 · External reference
Oxidized low density lipoprotein inhibits phosphate signaling and phosphate-induced mineralization in osteoblasts. Involvement of oxidative stress
10.1016/j.bbadis.2010.07.010 · 2010 · External reference
Osteoblast Demineralization Induced by Oxidized High-Density Lipoprotein via the Inflammatory Pathway Is Suppressed by Adiponectin
10.3390/ijms232314616 · 2022 · External reference
The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation
10.1002/jcb.23087 · 2011 · External reference
Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2
10.1016/j.mce.2012.05.002 · 2012 · External reference
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
10.1038/37284 · 1997 · External reference
Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-β-Smad3 pathway
10.1055/s-0028-1082051 · 2008 · External reference
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
10.1016/j.cmet.2015.12.010 · 2016 · External reference
Osteoclast differentiation and activation
10.1038/nature01658 · 2003 · External reference
Statins modulate the levels of osteoprotegerin/receptor activator of NF kappa B ligand mRNA in mouse bone-cell cultures
10.1055/s-2005-870538 · 2005 · External reference
Increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?
10.1007/s10557-009-6181-8 · 2009 · External reference
Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/beta-catenin signaling
10.1007/s10059-011-0107-6 · 2011 · External reference
Statin Use Is Associated With Decreased Osteoporosis and Fracture Risks in Stroke Patients
10.1210/jc.2018-00652 · 2018 · External reference
The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials.
10.1186/1741-7015-11-57 · 2013 · External reference
Alendronate and estrogen effects in postmenopausal women with low bone mineral density. Alendronate/Estrogen Study Group
2000 · External reference
Simvastatin decreases sex hormone levels in male rats.
10.4158/ep161274.or · 2017 · External reference
Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats
10.1016/j.reprotox.2015.10.005 · 2015 · External reference
Effect of Statins on Bone Mineral Density and Bone Histomorphometry in Rodents
10.1161/hq1001.097781 · 2001 · External reference
Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians
10.7326/m22-1034 · 2023 · External reference
UK clinical guideline for the prevention and treatment of osteoporosis.
10.1007/s11657-022-01061-5 · 2022 · External reference
Epidemiology of fractures in the United Kingdom 1988–2012: variation with age, sex, geography, ethnicity and socioeconomic status
10.1016/j.bone.2016.03.006 · 2016 · External reference
The epidemiology of osteoporosis
2020 · External reference
Long-term effect of statins on the risk of new-onset osteoporosis: A nationwide population-based cohort study.
10.1371/journal.pone.0196713 · 2018 · External reference
Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study.
10.12997/jla.2021.10.3.322 · 2021 · External reference
The Heart Protection Study: high-risk patients benefit from statins, regardless of LDL-C level.
10.3949/ccjm.70.11.991 · 2003 · External reference
Statins, Fracture Risk, and Bone Remodeling: What Is True?
10.1097/00000441-200608000-00001 · 2006 · External reference
Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study.
10.3390/ijerph182211902 · 2021 · External reference
Influence of non-osteoporotic treatments in patients on active anti-osteoporotic therapy: evidence from the OSTEOMED registry
10.1007/s00228-023-03544-x · 2023 · External reference
Pharmacologic characteristics of statins.
10.1002/clc.4960261507 · 2003 · External reference
Low dose hydrophilic statins are the preferred agents for females at risk of osteoporosis
2021 · External reference
Distribution of lovastatin to bone and its effect on bone turnover in rats
10.1211/jpp.58.11.0005 · 2006 · External reference
Incidence of vertebral fracture in Europe: results from the European perspective osteoporosis study (EPOS).
10.1359/jbmr.2002.17.4.716 · 2002 · External reference
What proportion of incident radiographic vertebral deformities is clinically diagnosed and vice versa
10.1359/jbmr.050314 · 2005 · External reference
Bone Health in Patients with Dyslipidemias
10.3390/ijms23031639 · 2022 · External reference
Association between lipid profiles and osteoporosis in postmenopausal women: A meta-analysis.
2018 · External reference
Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis
10.1007/s00774-020-01189-9 · 2021 · External reference
Association of Plasma High-Density Lipoprotein Cholesterol Level With Risk of Fractures in Healthy Older Adults
10.1001/jamacardio.2022.5124 · 2023 · External reference