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References from A lethal ORC ATPase mutation is suppressed by alterations in ORC and RNA Pol II transcription components. Local targets link to admitted publications; unresolved targets remain external evidence.
Chromosome duplication in Saccharomyces cerevisiae
10.1534/genetics.115.186452 · 2016 · External reference
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10.1016/j.cub.2014.04.012 · 2014 · External reference
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
10.1038/357128a0 · 1992 · External reference
The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
10.1038/s41467-021-24199-1 · 2021 · External reference
Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6
10.1038/s41467-020-18067-7 · 2020 · External reference
Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1
10.1038/nsmb.3372 · 2017 · External reference
Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6
10.1073/pnas.2006231117 · 2020 · External reference
Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading
10.1016/j.cell.2015.03.012 · 2015 · External reference
A helicase-tethered ORC flip enables bidirectional helicase loading
10.7554/elife.74282 · 2021 · External reference
Changing protein–DNA interactions promote ORC binding-site exchange during replication origin licensing
10.1073/pnas.2305556120 · 2023 · External reference
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM
10.1038/s41586-019-1768-0 · 2019 · External reference
Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading
10.1126/science.aan0063 · 2017 · External reference
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
10.1073/pnas.0911500106 · 2009 · External reference
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing
10.1016/j.cell.2009.10.015 · 2009 · External reference
Fundamental characteristics of AAA protein family structure and function
10.1155/2016/9294307 · 2016 · External reference
Structure and function of the AAA+ nucleotide binding pocket
10.1016/j.bbamcr.2011.06.014 · 2012 · External reference
The Cdc6p nucleotide-binding motif is required for loading Mcm proteins onto chromatin
10.1073/pnas.96.2.441 · 1999 · External reference
Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability
10.1128/mcb.00161-08 · 2008 · External reference
Multiple functions for Mcm2-7 ATPase motifs during replication initiation
10.1016/j.molcel.2014.06.033 · 2014 · External reference
Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase
10.1016/j.molcel.2014.06.034 · 2014 · External reference
ATPase-dependent quality control of DNA replication origin licensing
10.1038/nature11920 · 2013 · External reference
Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication
10.7554/elife.05795 · 2015 · External reference
Unidirectional MCM translocation away from ORC drives origin licensing
10.1038/s41467-025-56143-y · 2025 · External reference
Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome
10.1016/j.celrep.2019.07.104 · 2019 · External reference
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins
10.1016/j.molcel.2009.12.030 · 2010 · External reference
The mechanism of eukaryotic CMG helicase activation
10.1038/nature25787 · 2018 · External reference
CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism
2022 · External reference
ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication
10.1016/j.molcel.2004.11.038 · 2004 · External reference
Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex
10.1016/s0092-8674(00)81889-9 · 1997 · External reference
Establishment and function of chromatin organization at replication origins
10.1038/s41586-023-05926-8 · 2023 · External reference
Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
10.1016/s0092-8674(01)80009-x · 1997 · External reference
Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae
10.1111/j.1365-2443.2006.00967.x · 2006 · External reference
Transcription-replication conflicts as a source of genome instability
10.1146/annurev-genet-080320-031523 · 2023 · External reference
Relicensing of transcriptionally inactivated replication origins in budding yeast
10.1074/jbc.m110.148924 · 2010 · External reference
Perturbation of the activity of replication origin by meiosis-specific transcription
10.1074/jbc.m609671200 · 2007 · External reference
Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA
10.1016/j.molcel.2015.10.022 · 2015 · External reference
The chromatin environment shapes DNA replication origin organization and defines origin classes
10.1101/gr.192799.115 · 2015 · External reference
Metazoan DNA replication origins
10.1016/j.ceb.2019.03.003 · 2019 · External reference
Preventing replication stress to maintain genome stability: Resolving conflicts between replication and transcription
10.1016/j.molcel.2012.03.001 · 2012 · External reference
Mobile origin-licensing factors confer resistance to conflicts with RNA polymerase
10.1016/j.celrep.2022.110531 · 2022 · External reference
Looping out of control: R-loops in transcription-replication conflict
2023 · External reference
The red/white colony color assay in the yeast Saccharomyces cerevisiae: epistatic growth advantage of white ade8-18, ade2 cells over red ade2 cells
10.1007/s002940050160 · 1996 · External reference
5-Fluoroorotic acid as a selective agent in yeast molecular genetics
10.1016/0076-6879(87)54076-9 · 1987 · External reference
Mapping novel traits by array-assisted bulk segregant analysis in Saccharomyces cerevisiae
10.1534/genetics.106.057927 · 2006 · External reference
Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing
10.1534/genetics.110.123232 · 2010 · External reference
Isolation of two genes that encode subunits of the yeast transcription factor IIA
10.1126/science.1546313 · 1992 · External reference
Cas9-mediated gene editing in Saccharomyces cerevisiae
2017 · External reference
Cross-compartment signal propagation in the mitotic exit network
2021 · External reference
Crystal Structure of the Yeast TFIIA/TBP/DNA Complex
10.1126/science.272.5263.830 · 1996 · External reference
Crystal structure of a yeast TFIIA/TBP/DNA complex
10.1038/381127a0 · 1996 · External reference
Using DECIPHER v2.0 to analyze big biological sequence data in R
10.32614/rj-2016-025 · 2016 · External reference
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10.1093/bib/bbac222 · 2022 · External reference
MUSCLE: Multiple sequence alignment with high accuracy and high throughput
10.1093/nar/gkh340 · 2004 · External reference
PDBsum: A Web-based database of summaries and analyses of all PDB structures
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Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes
10.1016/s0022-2836(03)00887-8 · 2003 · External reference
The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators
1995 · External reference
In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization
10.1093/nar/gkt043 · 2013 · External reference
Nucleosomes influence multiple steps during replication initiation
2017 · External reference
ATP bound to the origin recognition complex is important for preRC formation
10.1073/pnas.131006898 · 2001 · External reference
The origin recognition complex in silencing, cell cycle progression, and DNA replication
10.1091/mbc.6.6.741 · 1995 · External reference
Expanded roles of the origin recognition complex in the architecture and function of silenced chromatin in Saccharomyces cerevisiae
10.1128/mcb.00614-09 · 2010 · External reference
ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA
10.1038/nsmb1002 · 2005 · External reference
Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro
10.1101/gad.14.13.1631 · 2000 · External reference
Association of Transcription Factor IIA with TATA Binding Protein Is Required for Transcriptional Activation of a Subset of Promoters and Cell Cycle Progression in Saccharomyces cerevisiae
10.1128/mcb.18.5.2559 · 2015 · External reference
TFIIA Interacts with TFIID via Association with TATA-Binding Protein and TAF40
10.1128/mcb.21.5.1737-1746.2001 · 2002 · External reference
A single point mutation in TFIIA suppresses NC2 requirement in vivo
10.1093/emboj/19.4.672 · 2000 · External reference
Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex
10.1128/mcb.24.18.8312-8321.2004 · 2004 · External reference
The TBP-TFIIA Interaction in the Response to Acidic Activators in vivo
10.1126/science.7604282 · 1995 · External reference
A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo
10.1128/mcb.17.3.1336 · 1997 · External reference
Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB
10.1093/genetics/153.2.643 · 1999 · External reference
Isolation, DNA sequence, and regulation of a Saccharomyces cerevisiae gene that encodes DNA strand transfer protein alpha
1991 · External reference
Homologue of TFIIS in yeast
10.1038/345298a0 · 1990 · External reference
Mechanism of start site selection by RNA polymerase II: Interplay between TFIIB and Ssl2/XPB helicase subunit of TFIIH
10.1074/jbc.m111.281576 · 2012 · External reference
Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae
10.7554/elife.71013 · 2021 · External reference
Conditional mutations occur predominantly in highly conserved residues of RNA polymerase II subunits
1990 · External reference
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators
10.1038/s41576-023-00630-9 · 2023 · External reference
The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes
10.1073/pnas.0704573104 · 2007 · External reference
The basal initiation machinery: Beyond the general transcription factors
10.1016/j.ceb.2009.03.006 · 2009 · External reference
Pervasive transcription fine-tunes replication origin activity
10.7554/elife.40802 · 2018 · External reference
Molecular impacts of Meier-Gorlin syndrome mutations on human origin licensing
10.1016/j.jbc.2025.111100 · 2026 · External reference
Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions
10.1038/nprot.2007.249 · 2007 · External reference
Protein-DNA interactions at a yeast replication origin
10.1038/357169a0 · 1992 · External reference
Chromatin Constrains the Initiation and Elongation of DNA Replication
10.1016/j.molcel.2016.10.035 · 2017 · External reference
Chromatin controls DNA replication origin selection, lagging-strand synthesis, and replication fork rates
10.1016/j.molcel.2016.11.016 · 2017 · External reference
Nucleosomes positioned by ORC facilitate the initiation of DNA replication
10.1016/s1097-2765(01)00151-4 · 2001 · External reference
Conserved nucleosome positioning defines replication origins
10.1101/gad.1913210 · 2010 · External reference
Origin recognition complex harbors an intrinsic nucleosome remodeling activity
2022 · External reference
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
10.1038/s41467-022-32657-7 · 2022 · External reference
Concerted interaction between origin recognition complex (ORC), nucleosomes and replication origin DNA ensures stable ORC-origin binding
10.1111/gtc.12073 · 2013 · External reference
Cdc6 ATPase Activity Regulates ORC·Cdc6 Stability and the Selection of Specific DNA Sequences as Origins of DNA Replication
10.1074/jbc.m700399200 · 2007 · External reference
A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6
10.1038/s41467-022-28695-w · 2022 · External reference
TATA-binding protein mutants that are lethal in the absence of the Nhp6 high-mobility-group protein
10.1128/mcb.24.14.6419-6429.2004 · 2004 · External reference
Preventing replication fork collapse to maintain genome integrity
10.1016/j.dnarep.2015.04.026 · 2015 · External reference
Transcription as a threat to genome integrity
10.1146/annurev-biochem-060815-014908 · 2016 · External reference
Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae
10.1016/j.molcel.2009.05.022 · 2009 · External reference
Separation of DNA Replication from the Assembly of Break-Competent Meiotic Chromosomes
10.1371/journal.pgen.1002643 · 2012 · External reference
Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats
2019 · External reference
Bidirectional promoters generate pervasive transcription in yeast
10.1038/nature07728 · 2009 · External reference
Widespread bidirectional promoters are the major source of cryptic transcripts in yeast
10.1038/nature07747 · 2009 · External reference
Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae
10.1093/nar/24.22.4450 · 1996 · External reference
INO80C remodeler maintains genomic stability by preventing promiscuous transcription at replication origins
10.1016/j.celrep.2020.108106 · 2020 · External reference
Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome
10.1101/gad.1682308 · 2008 · External reference
Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals
2017 · External reference
Transcription shapes DNA replication initiation to preserve genome integrity
10.1186/s13059-021-02390-3 · 2021 · External reference
Replication landscape of the human genome
10.1038/ncomms10208 · 2016 · External reference
Emergence of replication timing during early mammalian development
10.1038/s41586-023-06872-1 · 2024 · External reference
Transcription shapes DNA replication initiation and termination in human cells
10.1038/s41594-018-0171-0 · 2019 · External reference
Sequence-independent DNA binding and replication initiation by the human origin recognition complex
10.1101/gad.1084203 · 2003 · External reference
Origins of DNA replication
10.1371/journal.pgen.1008320 · 2019 · External reference
A rapid, efficient method for isolating DNA from yeast
10.1016/0378-1119(86)90293-3 · 1986 · External reference
Whole-genome sequencing of yeast cells
10.1002/cpmb.103 · 2019 · External reference
Fast and accurate short read alignment with Burrows-Wheeler transform
10.1093/bioinformatics/btp324 · 2009 · External reference
The Sequence Alignment/Map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method
10.1038/nprot.2007.13 · 2007 · External reference
Extraction of genomic DNA from yeasts for PCR-based applications
10.2144/000113672 · 2011 · External reference
Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing
10.1073/pnas.2221484120 · 2023 · External reference
NIH Image to ImageJ: 25 years of image analysis
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Unresolved reference
External reference
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2016 · External reference
