Research graph
References from Neutrophil-derived oncostatin m contributes to endothelial cell dysfunction during Treponema denticola interaction. Local targets link to admitted publications; unresolved targets remain external evidence.
Periodontitis is associated to increased systemic inflammation in postmyocardial infarction patients
2021 · External reference
Correlation of levels of oncostatin M cytokine in crevicular fluid and serum in periodontal disease
10.4248/ijos10077 · 2010 · External reference
Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis
10.4103/0972-124x.55840 · 2009 · External reference
Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases
10.1080/00325481.2018.1396876 · 2018 · External reference
Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients
10.1902/jop.2000.71.10.1528 · 2000 · External reference
Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012
10.1902/jop.2015.140520 · 2015 · External reference
Global burden of periodontal diseases among the working-age population from 1990-2021: results from the Global Burden of Disease Study 2021
10.1186/s12889-025-22566-x · 2025 · External reference
Burden of severe periodontitis and edentulism in 2021, with projections up to 2050: The Global Burden of Disease 2021 study
10.1111/jre.13337 · 2024 · External reference
The pathogenesis of human periodontitis: an introduction
10.1111/j.1600-0757.1997.tb00189.x · 1997 · External reference
Potential for gingival crevice fluid measures as predictors of risk for periodontal diseases
10.1034/j.1600-0757.2003.03110.x · 2003 · External reference
The diversity of periodontal spirochetes by 16S rRNA analysis
10.1034/j.1399-302x.2000.150308.x · 2000 · External reference
Periodontitis: a polymicrobial disruption of host homeostasis
10.1038/nrmicro2337 · 2010 · External reference
Diversity of cultivable and uncultivable oral spirochetes from a patient with severe destructive periodontitis
10.1128/iai.62.5.1889-1895.1994 · 1994 · External reference
Association between periodontal disease and systemic diseases: a cross-sectional analysis of current evidence
2024 · External reference
Periodontal disease: A systemic condition
10.1111/prd.12616 · 2024 · External reference
Association between periodontal disease and atherosclerotic cardiovascular diseases: revisited
10.3389/fcvm.2020.625579 · 2020 · External reference
Risk of incident cardiovascular disease in people with periodontal disease: A systematic review and meta-analysis
10.1002/cre2.336 · 2021 · External reference
Periodontitis and the Risk of Heart Failure:a Meta-analysis and Mendelian Randomisation Study
2025 · External reference
Executive summary: heart disease and stroke statistics--2012 update: a report from the American Heart Association
10.1161/cir.0b013e3182456d46 · 2012 · External reference
Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study
2020 · External reference
Heart failure: assessment of the global economic burden
10.1093/eurheartj/ehaf323 · 2025 · External reference
Global, regional, and national burden of cardiovascular diseases and risk factors in 204 countries and territories, 1990-2023
10.1016/j.jacc.2025.08.015 · 2025 · External reference
Systemic effects of periodontitis: lessons learned from research on atherosclerotic vascular disease and adverse pregnancy outcomes
10.1111/idj.12185 · 2015 · External reference
Systemic inflammatory response to non-surgical treatment in hypertensive patients with periodontal infection
10.1097/md.0000000000024951 · 2021 · External reference
Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study
10.3389/froh.2025.1488941 · 2025 · External reference
The Dual Nature of Oncostatin M: Context-Dependent Mediator of Immunity and Fibrosis
10.1007/s12013-025-01954-5 · 2026 · External reference
Treponema denticola stimulates Oncostatin M cytokine release and de novo synthesis in neutrophils and macrophages
10.1002/jlb.4ma0620-072rr · 2020 · External reference
Comparison of oncostatin M cytokine levels in saliva and serum in periodontitis: a clinicobiochemical study
2024 · External reference
Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease
10.3109/13547500903573209 · 2010 · External reference
The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis
10.1038/s41368-023-00275-8 · 2024 · External reference
Natural and induced immune responses in oral cavity and saliva
10.1186/s12865-025-00713-8 · 2025 · External reference
Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease
10.1016/j.jaci.2016.10.039 · 2017 · External reference
Oncostatin M production and regulation by human polymorphonuclear neutrophils
10.1182/blood.v93.4.1413 · 1999 · External reference
Emerging oral Treponema membrane proteins disorder neutrophil phosphoinositide signaling via phosphatidylinositol-4-phosphate 5-kinase
10.3389/froh.2025.1568983 · 2025 · External reference
Polymicrobial periodontal disease triggers a wide radius of effect and unique virome
10.1038/s41522-020-0120-7 · 2020 · External reference
Oncostatin M and Cardiovascular Diseases: A Narrative Review
2025 · External reference
Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells
10.3390/ijms23031448 · 2022 · External reference
Oncostatin M is expressed in atherosclerotic lesions: a role for Oncostatin M in the pathogenesis of atherosclerosis
10.1016/j.atherosclerosis.2011.02.003 · 2011 · External reference
Exogenous oncostatin M induces cardiac dysfunction, musculoskeletal atrophy, and fibrosis
10.1016/j.cyto.2022.155972 · 2022 · External reference
Oncostatin M promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the NF-κB pathway in THP-1 macrophages and promotes the progression of atherosclerosis
10.21037/atm-22-560 · 2022 · External reference
Endothelial Cell Dysfunction: Onset, Progression, and Consequences
10.31083/j.fbl2906223 · 2024 · External reference
Endothelial Barrier and Its Abnormalities in Cardiovascular Disease
10.3389/fphys.2015.00365 · 2015 · External reference
Endothelial dysfunction: the early predictor of atherosclerosis
10.5830/cvja-2011-068 · 2012 · External reference
Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice
10.1371/journal.pone.0204911 · 2018 · External reference
Endothelial signaling by neutrophil-released oncostatin M enhances P-selectin-dependent inflammation and thrombosis
10.1182/bloodadvances.2018026294 · 2019 · External reference
Large and small vessels atherosclerosis: similarities and differences
10.1016/j.pcad.2007.04.001 · 2007 · External reference
Macroscopic distribution of coronary atherosclerotic lesions in cholesterol-fed rabbits
10.1538/expanim.47.221 · 1998 · External reference
Pathogenesis of atherosclerosis
10.1016/j.jacc.2005.09.068 · 2006 · External reference
Laboratory maintenance of Treponema denticola
2005 · External reference
Analysis of Neutrophil Responses to Biological Exposures
10.1002/cpz1.827 · 2023 · External reference
High-purity neutrophil isolation from human peripheral blood and saliva for transcriptome analysis
10.1007/978-1-62703-845-4_28 · 2014 · External reference
IFN-γ regulates human dental pulp stem cells behavior via NF-κB and MAPK signaling
10.1038/srep40681 · 2017 · External reference
Effects of drospirenone on adhesion molecule expression and monocyte adherence in human endothelial cells
10.1016/j.ejogrb.2016.03.044 · 2016 · External reference
Leucocyte- and platelet-rich fibrin regulates expression of genes related to early wound healing in human gingival fibroblasts
10.1111/jcpe.13293 · 2020 · External reference
Oral neutrophils display a site-specific phenotype characterized by expression of T-cell receptors
10.1902/jop.2012.120477 · 2013 · External reference
Interleukin-1 beta enhances human multipotent mesenchymal stromal cell proliferative potential and their ability to maintain hematopoietic precursor cells
10.1016/j.cyto.2014.10.018 · 2015 · External reference
Topology and functional characterization of major outer membrane proteins of Treponema maltophilum and Treponema lecithinolyticum
10.1111/omi.12484 · 2025 · External reference
Elevation of plasma oncostatin M in heart failure
10.2217/fca-2016-0063 · 2017 · External reference
Oncostatin M is a novel biomarker for coronary artery disease - A possibility as a screening tool of silent myocardial ischemia for diabetes mellitus
2021 · External reference
Myeloid Ezh2 deficiency limits atherosclerosis development
10.3389/fimmu.2020.594603 · 2020 · External reference
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
10.1038/s44161-021-00002-8 · 2022 · External reference
Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling
10.1152/ajpheart.00400.2008 · 2008 · External reference
ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration
10.1182/blood-2011-12-397430 · 2012 · External reference
Essential role of ICAM-1 in aldosterone-induced atherosclerosis
10.1016/j.ijcard.2017.01.013 · 2017 · External reference
Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes
10.1038/s41467-024-54124-1 · 2024 · External reference
Leukemia inhibitory factor receptor inhibition by EC359 reduces atherosclerotic stenosis grade in Ldlr-/- mice
10.1016/j.ejphar.2024.177121 · 2024 · External reference
Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages
10.1194/jlr.m074112 · 2017 · External reference
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies
10.1016/j.molmed.2020.11.006 · 2021 · External reference
Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions
10.1084/jem.186.4.517 · 1997 · External reference
TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia
10.1152/ajplung.00109.2006 · 2006 · External reference
Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing
10.1038/ismej.2011.191 · 2012 · External reference
New insights into the emerging role of oral spirochaetes in periodontal disease
10.1111/j.1469-0691.2011.03460.x · 2011 · External reference
Proteomic Characterization of 1000 Human and Murine Neutrophils Freshly Isolated From Blood and Sites of Sterile Inflammation
10.1016/j.mcpro.2024.100858 · 2024 · External reference
Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures
10.1038/s41598-024-56163-6 · 2024 · External reference
Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States
2022 · External reference
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
10.1186/s11658-023-00423-2 · 2023 · External reference
Dysfunction of endothelial nitric oxide synthase and atherosclerosis
10.1161/01.atv.0000125114.88079.96 · 2004 · External reference
Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age
10.1016/j.abb.2006.02.017 · 2006 · External reference
Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers
10.1164/ajrccm.164.4.2101023 · 2001 · External reference
Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis
10.1161/01.cir.97.25.2494 · 1998 · External reference
Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules
10.1172/jci119508 · 1997 · External reference
Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins
10.1126/science.2466335 · 1989 · External reference
ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex
10.1126/science.1701274 · 1990 · External reference
E-selectin in vascular pathophysiology
10.3389/fimmu.2024.1401399 · 2024 · External reference
Exclusive neutrophil recruitment with oncostatin M in a human system
10.1016/s0002-9440(10)62538-2 · 2001 · External reference
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow
10.1182/blood-2004-12-4942 · 2005 · External reference
Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study
10.1161/01.atv.0000016249.96529.b8 · 2002 · External reference
Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men
10.1016/s0140-6736(97)09032-6 · 1998 · External reference
Effects of oncostatin M on human cerebral endothelial cells and expression in inflammatory brain lesions
10.1093/jnen/60.11.1087 · 2001 · External reference
Oncostatin M and TLR-4 ligand synergize to induce MCP-1, IL-6, and VEGF in human aortic adventitial fibroblasts and smooth muscle cells
10.1155/2013/317503 · 2013 · External reference
The Role of Interleukin-8 in the Estimation of Responsiveness to Steps 1 and 2 of Periodontal Therapy
10.1111/jcpe.14055 · 2024 · External reference
Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis
10.1097/md.0000000000006932 · 2017 · External reference
Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitis
10.1902/jop.2000.71.6.929 · 2000 · External reference
Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules
10.1038/s41598-022-12358-3 · 2022 · External reference
Serum cytokines in periodontal diseases
10.1111/prd.12629 · 2025 · External reference
The Role of JAK/STAT Signaling Pathway and Its Downstream Influencing Factors in the Treatment of Atherosclerosis
10.1177/10742484241248046 · 2024 · External reference
Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-induced Cell Responses during Atherosclerosis in Apolipoprotein E-deficient Mice
10.1038/srep36790 · 2016 · External reference
Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis
10.7150/thno.35528 · 2019 · External reference
Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure
10.1016/j.jtcvs.2004.06.046 · 2004 · External reference
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction
10.1371/journal.pone.0156562 · 2016 · External reference
The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice
10.1074/jbc.ra118.004375 · 2018 · External reference
Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice
10.3390/ijms23010353 · 2021 · External reference
VE-cadherin: at the front, center, and sides of endothelial cell organization and function
10.1016/j.ceb.2010.07.006 · 2010 · External reference
Unveiling endothelial cell border heterogeneity: VE-cadherin adherens junction stratification by deep convolutional neural networks
10.1371/journal.pone.0317110 · 2025 · External reference
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
10.1038/ncomms11017 · 2016 · External reference
Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity
10.1007/s00401-022-02445-0 · 2022 · External reference
A characteristic subset of psoriasis-associated genes is induced by oncostatin-M in reconstituted epidermis
10.1038/sj.jid.5700461 · 2006 · External reference
Gingipain and oncostatin M synergistically disrupt kidney tight junctions in periodontitis-associated acute kidney injury
10.1002/jper.24-0007 · 2024 · External reference
Localization of Outer Membrane Proteins in Treponema denticola by Quantitative Proteome Analyses of Outer Membrane Vesicles and Cellular Fractions
10.1021/acs.jproteome.8b00860 · 2019 · External reference
The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils
10.1128/iai.00553-19 · 2019 · External reference
Oncostatin M production by human dendritic cells in response to bacterial products
10.1006/cyto.2002.1023 · 2002 · External reference
Helicobacter pylori induces expression and secretion of oncostatin M in macrophages in vitro
10.1007/s10620-010-1341-z · 2011 · External reference
Helicobacter pylori outer membrane vesicles induce expression and secretion of oncostatin M in AGS gastric cancer cells
10.1007/s42770-021-00490-7 · 2021 · External reference
Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma
10.1126/scitranslmed.abf8188 · 2022 · External reference
Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia
10.1165/rcmb.2007-0365oc · 2008 · External reference
Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing
10.1128/jvi.00502-08 · 2008 · External reference
Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage
10.4049/jimmunol.181.1.698 · 2008 · External reference
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
10.1073/pnas.0307639101 · 2004 · External reference
Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides
10.1074/jbc.273.25.15661 · 1998 · External reference
Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation
10.1074/jbc.m010481200 · 2001 · External reference
Activation of murine macrophages by lipoprotein and lipooligosaccharide of Treponema denticola
10.1128/iai.67.3.1180-1186.1999 · 1999 · External reference
Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath components
10.1128/iai.00488-09 · 2009 · External reference
Induction of osteoclastogenesis and matrix metalloproteinase expression by the lipooligosaccharide of Treponema denticola
10.1128/iai.71.1.226-233.2003 · 2003 · External reference
Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids
10.4049/jimmunol.165.5.2683 · 2000 · External reference
Nitric oxide synthases: regulation and function
10.1093/eurheartj/ehr304 · 2012 · External reference
IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia
10.1002/glia.20989 · 2010 · External reference
Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M
10.1002/glia.22739 · 2015 · External reference
Microenvironmental determinants of endothelial cell heterogeneity
10.1038/s41580-024-00825-w · 2025 · External reference
Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system
10.1038/srep28832 · 2016 · External reference
The pattern of cytokine messenger RNA expression in human aortic endothelial cells is different from that of human umbilical vein endothelial cells
10.1016/0966-3274(93)90007-u · 1993 · External reference
Cyclic strain and motion control produce opposite oxidative responses in two human endothelial cell types
2007 · External reference
