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References from Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes. Local targets link to admitted publications; unresolved targets remain external evidence.
Biomarkers for the diagnosis and management of heart failure
10.1007/s10741-021-10105-w · 2022 · External reference
Global, regional, and national burden of heart failure and its underlying causes, 1990-2021: results from the global burden of disease study 2021
10.1186/s40364-025-00728-8 · 2025 · External reference
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
10.1093/eurheartj/ehab368 · 2021 · External reference
Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction
10.1161/circulationaha.114.009625 · 2015 · External reference
Epigenetic regulation by ketone bodies in cardiac diseases and repair
10.1139/cjpp-2024-0270 · 2025 · External reference
Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation
10.1016/j.molcel.2016.03.036 · 2016 · External reference
Proteome-wide analysis of lysine β-hydroxybutyrylation in the myocardium of diabetic rat model with cardiomyopathy
10.3389/fcvm.2022.1066822 · 2023 · External reference
BDH1 overexpression alleviates diabetic cardiomyopathy through inhibiting H3K9bhb-mediated transcriptional activation of LCN2
2025 · External reference
The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway
10.1126/sciadv.abe2771 · 2021 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2
10.1093/bioinformatics/btac409 · 2022 · External reference
Make Interactive Complex Heatmaps in R
10.1093/bioinformatics/btab806 · 2022 · External reference
Ferroptosis and autophagy-related genes in the pathogenesis of ischemic cardiomyopathy
10.3389/fcvm.2022.906753 · 2022 · External reference
ClusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
Differentiation of T Helper 17 Cells May Mediate the Abnormal Humoral Immunity in IgA Nephropathy and Inflammatory Bowel Disease Based on Shared Genetic Effects
10.3389/fimmu.2022.916934 · 2022 · External reference
Potential molecular mechanisms of plantain in the treatment of gout and hyperuricemia based on network pharmacology
2020 · External reference
Elastic Net Regularization Paths for All Generalized Linear Models
2023 · External reference
Feature selection using a one dimensional naïve Bayes’ classifier increases the accuracy of support vector machine classification of CDR3 repertoires
10.1093/bioinformatics/btw771 · 2017 · External reference
Machine learning for the prediction of acute kidney injury in patients with sepsis
10.1186/s12967-022-03364-0 · 2022 · External reference
pROC: an open-source package for R and S+ to analyze and compare ROC curves
10.1186/1471-2105-12-77 · 2011 · External reference
Characterization of the Immune Cell Infiltration Landscape in Esophageal Squamous Cell Carcinoma
10.3389/fonc.2022.879326 · 2022 · External reference
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery
10.1016/j.ijsu.2022.106936 · 2022 · External reference
Integrative Analysis of Multi-Omics Identified the Prognostic Biomarkers in Acute Myelogenous Leukemia
10.3389/fonc.2020.591937 · 2020 · External reference
IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures
10.3389/fimmu.2021.687975 · 2021 · External reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · 2015 · External reference
Spatial reconstruction of single-cell gene expression data
10.1038/nbt.3192 · 2015 · External reference
Key cell types and biomarkers in heart failure identified through analysis of single-cell and bulk RNA sequencing data
10.1155/2023/8384882 · 2023 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
CellMarker: a manually curated resource of cell markers in human and mouse
2019 · External reference
CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data
2023 · External reference
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
10.1038/nbt.2859 · 2014 · External reference
Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level
10.1007/s00395-021-00897-1 · 2021 · External reference
Heme oxygenase-1: An anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders
10.3390/antiox11030555 · 2022 · External reference
Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice
10.1371/journal.pone.0292990 · 2023 · External reference
Role of noncanonical histone H2A variant, H2A.Z, to maintain proper centromeric transcription and chromosome segregation
10.1016/j.jbc.2025.108464 · 2025 · External reference
Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression
10.15252/embr.202052061 · 2021 · External reference
Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0
10.1007/s00439-022-02432-1 · 2022 · External reference
m6A Modification Mediates Mucosal Immune Microenvironment and Therapeutic Response in Inflammatory Bowel Disease
10.3389/fcell.2021.692160 · 2021 · External reference
H2AFZ: A Novel Prognostic Marker in Canine Melanoma and a Predictive Marker for Resistance to CDK4/6 Inhibitor Treatment
10.3389/fvets.2021.705359 · 2021 · External reference
H2AFZ Is a Prognostic Biomarker Correlated to TP53 Mutation and Immune Infiltration in Hepatocellular Carcinoma
10.3389/fonc.2021.701736 · 2021 · External reference
Inhibition of KPNA2 by ivermectin reduces E2F1 nuclear translocation to attenuate keratinocyte proliferation and ameliorate psoriasis-like lesions
10.1016/j.intimp.2024.113360 · 2024 · External reference
KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1
10.1038/s41388-025-03375-3 · 2025 · External reference
KPNA2 promotes renal cell carcinoma proliferation and metastasis via NPM
10.1111/jcmm.16846 · 2021 · External reference
Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
10.15252/emmm.202215984 · 2023 · External reference
KPNA2 Silencing, Regulated by E3 Ubiquitin Ligase FBXW7, Alleviates Endothelial Dysfunction and Inflammation Through Inhibiting the Nuclear Translocation of p65 and IRF3: A Possible Therapeutic Approach for Atherosclerosis
10.1007/s10753-023-01863-w · 2023 · External reference
KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway
10.1186/s12967-021-02709-5 · 2021 · External reference
Oncogenic role of karyopherin α2 (KPNA2) in human tumors: A pan-cancer analysis
10.1016/j.compbiomed.2021.104955 · 2021 · External reference
KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation
10.1186/s12967-022-03841-6 · 2022 · External reference
The E3 ubiquitin ligase CHIP protects against sepsis-induced myocardial dysfunction by inhibiting NF-κB-mediated inflammation via promoting ubiquitination and degradation of karyopherin-α 2
10.1016/j.trsl.2022.11.006 · 2023 · External reference
Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome-Wide Mendelian Randomization and Colocalization Analysis
10.1155/cdr/5711316 · 2025 · External reference
Status of Mitochondrial Oxidative Phosphorylation during the Development of Heart Failure
10.3390/antiox12111941 · 2023 · External reference
Cardiac Energy Metabolism in Heart Failure
10.1161/circresaha.121.318241 · 2021 · External reference
β-Hydroxybutyrate Facilitates Postinfarction Cardiac Repair via Targeting PHD2
10.1161/circresaha.124.325179 · 2025 · External reference
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4
2025 · External reference
Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning
10.3389/fmolb.2025.1580880 · 2025 · External reference
Exposure to bisphenol A associated with multiple health-related outcomes in humans: An umbrella review of systematic reviews with meta-analyses
10.1016/j.envres.2023.116900 · 2023 · External reference
Association of urinary bisphenol A levels with heart failure risk in U.S. adults from the NHANES (2003–2016)
2024 · External reference
Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases
10.3390/jox13040049 · 2023 · External reference
Integrative analysis of DNA methylome and transcriptome reveals epigenetic regulation of bisphenols-induced cardiomyocyte hypertrophy
10.1016/j.ecoenv.2023.115391 · 2023 · External reference
Relationship between emergent BPA-substitutes and renal and cardiovascular diseases in adult population
10.1016/j.envpol.2022.120106 · 2022 · External reference
Immune cell infiltration landscapes in pediatric acute myocarditis analyzed by CIBERSORT
10.1016/j.jjcc.2020.08.004 · 2021 · External reference
Machine learning based deconvolution of microarray atrial samples from atrial fibrillation patients reveals increased fractions of follicular CD4+ T lymphocytes and gamma-delta T cells
2021 · External reference
Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level
10.1007/s00395-021-00897-1 · ExternalCitation · doi-reference
Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0
10.1007/s00439-022-02432-1 · ExternalCitation · doi-reference
Biomarkers for the diagnosis and management of heart failure
10.1007/s10741-021-10105-w · ExternalCitation · doi-reference
KPNA2 Silencing, Regulated by E3 Ubiquitin Ligase FBXW7, Alleviates Endothelial Dysfunction and Inflammation Through Inhibiting the Nuclear Translocation of p65 and IRF3: A Possible Therapeutic Approach for Atherosclerosis
10.1007/s10753-023-01863-w · ExternalCitation · doi-reference
Oncogenic role of karyopherin α2 (KPNA2) in human tumors: A pan-cancer analysis
10.1016/j.compbiomed.2021.104955 · ExternalCitation · doi-reference
Integrative analysis of DNA methylome and transcriptome reveals epigenetic regulation of bisphenols-induced cardiomyocyte hypertrophy
10.1016/j.ecoenv.2023.115391 · ExternalCitation · doi-reference
Relationship between emergent BPA-substitutes and renal and cardiovascular diseases in adult population
10.1016/j.envpol.2022.120106 · ExternalCitation · doi-reference
Exposure to bisphenol A associated with multiple health-related outcomes in humans: An umbrella review of systematic reviews with meta-analyses
10.1016/j.envres.2023.116900 · ExternalCitation · doi-reference
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery
10.1016/j.ijsu.2022.106936 · ExternalCitation · doi-reference
Inhibition of KPNA2 by ivermectin reduces E2F1 nuclear translocation to attenuate keratinocyte proliferation and ameliorate psoriasis-like lesions
10.1016/j.intimp.2024.113360 · ExternalCitation · doi-reference
Role of noncanonical histone H2A variant, H2A.Z, to maintain proper centromeric transcription and chromosome segregation
10.1016/j.jbc.2025.108464 · ExternalCitation · doi-reference
Immune cell infiltration landscapes in pediatric acute myocarditis analyzed by CIBERSORT
10.1016/j.jjcc.2020.08.004 · ExternalCitation · doi-reference
Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation
10.1016/j.molcel.2016.03.036 · ExternalCitation · doi-reference
The E3 ubiquitin ligase CHIP protects against sepsis-induced myocardial dysfunction by inhibiting NF-κB-mediated inflammation via promoting ubiquitination and degradation of karyopherin-α 2
10.1016/j.trsl.2022.11.006 · ExternalCitation · doi-reference
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
10.1038/nbt.2859 · ExternalCitation · doi-reference
Spatial reconstruction of single-cell gene expression data
10.1038/nbt.3192 · ExternalCitation · doi-reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · ExternalCitation · doi-reference
KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1
10.1038/s41388-025-03375-3 · ExternalCitation · doi-reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · ExternalCitation · doi-reference
Make Interactive Complex Heatmaps in R
10.1093/bioinformatics/btab806 · ExternalCitation · doi-reference
ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2
10.1093/bioinformatics/btac409 · ExternalCitation · doi-reference
Feature selection using a one dimensional naïve Bayes’ classifier increases the accuracy of support vector machine classification of CDR3 repertoires
10.1093/bioinformatics/btw771 · ExternalCitation · doi-reference
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
10.1093/eurheartj/ehab368 · ExternalCitation · doi-reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · ExternalCitation · doi-reference
KPNA2 promotes renal cell carcinoma proliferation and metastasis via NPM
10.1111/jcmm.16846 · ExternalCitation · doi-reference
The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway
10.1126/sciadv.abe2771 · ExternalCitation · doi-reference
Epigenetic regulation by ketone bodies in cardiac diseases and repair
10.1139/cjpp-2024-0270 · ExternalCitation · doi-reference
Key cell types and biomarkers in heart failure identified through analysis of single-cell and bulk RNA sequencing data
10.1155/2023/8384882 · ExternalCitation · doi-reference
Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome-Wide Mendelian Randomization and Colocalization Analysis
10.1155/cdr/5711316 · ExternalCitation · doi-reference
Cardiac Energy Metabolism in Heart Failure
10.1161/circresaha.121.318241 · ExternalCitation · doi-reference
β-Hydroxybutyrate Facilitates Postinfarction Cardiac Repair via Targeting PHD2
10.1161/circresaha.124.325179 · ExternalCitation · doi-reference
Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction
10.1161/circulationaha.114.009625 · ExternalCitation · doi-reference
pROC: an open-source package for R and S+ to analyze and compare ROC curves
10.1186/1471-2105-12-77 · ExternalCitation · doi-reference
KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway
10.1186/s12967-021-02709-5 · ExternalCitation · doi-reference
Machine learning for the prediction of acute kidney injury in patients with sepsis
10.1186/s12967-022-03364-0 · ExternalCitation · doi-reference
KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation
10.1186/s12967-022-03841-6 · ExternalCitation · doi-reference
Global, regional, and national burden of heart failure and its underlying causes, 1990-2021: results from the global burden of disease study 2021
10.1186/s40364-025-00728-8 · ExternalCitation · doi-reference
Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice
10.1371/journal.pone.0292990 · ExternalCitation · doi-reference
Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression
10.15252/embr.202052061 · ExternalCitation · doi-reference
Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
10.15252/emmm.202215984 · ExternalCitation · doi-reference
m6A Modification Mediates Mucosal Immune Microenvironment and Therapeutic Response in Inflammatory Bowel Disease
10.3389/fcell.2021.692160 · ExternalCitation · doi-reference
Proteome-wide analysis of lysine β-hydroxybutyrylation in the myocardium of diabetic rat model with cardiomyopathy
10.3389/fcvm.2022.1066822 · ExternalCitation · doi-reference
Ferroptosis and autophagy-related genes in the pathogenesis of ischemic cardiomyopathy
10.3389/fcvm.2022.906753 · ExternalCitation · doi-reference
IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures
10.3389/fimmu.2021.687975 · ExternalCitation · doi-reference
Differentiation of T Helper 17 Cells May Mediate the Abnormal Humoral Immunity in IgA Nephropathy and Inflammatory Bowel Disease Based on Shared Genetic Effects
10.3389/fimmu.2022.916934 · ExternalCitation · doi-reference
Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning
10.3389/fmolb.2025.1580880 · ExternalCitation · doi-reference
Integrative Analysis of Multi-Omics Identified the Prognostic Biomarkers in Acute Myelogenous Leukemia
10.3389/fonc.2020.591937 · ExternalCitation · doi-reference
H2AFZ Is a Prognostic Biomarker Correlated to TP53 Mutation and Immune Infiltration in Hepatocellular Carcinoma
10.3389/fonc.2021.701736 · ExternalCitation · doi-reference
Characterization of the Immune Cell Infiltration Landscape in Esophageal Squamous Cell Carcinoma
10.3389/fonc.2022.879326 · ExternalCitation · doi-reference
H2AFZ: A Novel Prognostic Marker in Canine Melanoma and a Predictive Marker for Resistance to CDK4/6 Inhibitor Treatment
10.3389/fvets.2021.705359 · ExternalCitation · doi-reference
Heme oxygenase-1: An anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders
10.3390/antiox11030555 · ExternalCitation · doi-reference
Status of Mitochondrial Oxidative Phosphorylation during the Development of Heart Failure
10.3390/antiox12111941 · ExternalCitation · doi-reference
Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases
10.3390/jox13040049 · ExternalCitation · doi-reference
