Research graph
References from Voltage-gated sodium channel, Nav 1.8, regulates calcium dynamics in the dorsal root ganglion induced by cold nociceptive stimulus. Local targets link to admitted publications; unresolved targets remain external evidence.
Cellular and Molecular Mechanisms of Pain
2009 · External reference
Coupled activation of primary sensory neurons contributes to chronic pain
10.1016/j.neuron.2016.07.044 · 2016 · External reference
Dorsal Root Ganglion (DRG) and Chronic Pain
10.5812/aapm.113020 · 2021 · External reference
Molecular mechanisms of cold pain
10.1016/j.ynpai.2020.100044 · 2020 · External reference
Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo
10.1016/s0304-3959(02)00122-7 · 2003 · External reference
Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice
10.1186/s12974-024-03018-6 · 2024 · External reference
A quantitative description of membrane current and its application to conduction and excitation in nerve
10.1113/jphysiol.1952.sp004764 · 1952 · External reference
Neuronal voltage-gated calcium channels: structure, function, and dysfunction
10.1016/j.neuron.2014.03.016 · 2014 · External reference
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex
10.1038/nm.2345 · 2011 · External reference
The effect of calcium channel antagonists on peripheral neurones
10.1111/j.1749-6632.1988.tb33364.x · 1988 · External reference
Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro
10.1113/jphysiol.1990.sp018094 · 1990 · External reference
Targeting chronic and neuropathic pain: the N-type calcium channel comes of age
10.1602/neurorx.2.4.662 · 2005 · External reference
Calcium channel modulation as a target in chronic pain control
10.1111/bph.13789 · 2018 · External reference
Ion Channel Genes in Painful Neuropathies
10.3390/biomedicines11102680 · 2023 · External reference
The role of voltage-gated sodium channels in neuropathic pain
10.1016/s0959-4388(03)00074-6 · 2003 · External reference
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels
10.1016/s0896-6273(00)81133-2 · 2000 · External reference
Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay
10.1177/1744806917745179 · 2017 · External reference
Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons
10.1523/jneurosci.22-23-10277.2002 · 2002 · External reference
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
10.1038/379257a0 · 1996 · External reference
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
10.1038/nature05880 · 2007 · External reference
Cold sensing by NaV1.8-positive and NaV1.8-negative sensory neurons
10.1073/pnas.1814545116 · 2019 · External reference
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
10.1073/pnas.0611364104 · 2007 · External reference
Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models
10.1016/j.neulet.2021.135844 · 2021 · External reference
In vivo calcium imaging of neuronal ensembles in networks of primary sensory neurons in intact dorsal root ganglia
10.3791/64826 · 2023 · External reference
Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain
10.1016/j.neuron.2016.07.044 · 2016 · External reference
Thy1-GCaMP6 transgenic mice for neuronal population imaging in vivo
10.1371/journal.pone.0108697 · 2014 · External reference
Chemogenetic silencing of Na(V)1.8-positive sensory neurons reverses chronic neuropathic and bone cancer pain in FLEx PSAM(4)-GlyR mice
10.1523/eneuro.0151-23.2023 · 2023 · External reference
Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
10.1016/0304-3959(94)90023-x · 1994 · External reference
Nifedipine facilitates neurotransmitter release independently of calcium channels
10.1073/pnas.0936131100 · 2003 · External reference
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice
10.1016/0028-3908(90)90145-h · 1990 · External reference
A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats
10.1124/jpet.107.134148 · 2008 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Effects of veratridine on sodium currents and fluxes
1998 · External reference
Long-term enhancement of synaptic transmission induced by veratridine in rat CA3 hippocampal neurons
10.1016/s0168-0102(01)00199-7 · 2001 · External reference
Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons
10.1038/srep45221 · 2017 · External reference
Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8
10.1073/pnas.2208211119 · 2022 · External reference
Expression and role of voltage-gated sodium channels in human dorsal root ganglion neurons with special focus on Nav1.7, species differences, and regulation by paclitaxel
10.1007/s12264-017-0132-3 · 2018 · External reference
Nav1.7 and Nav1.8: Role in the pathophysiology of pain
10.1177/1744806919858801 · 2019 · External reference
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8
10.1016/s0304-3959(01)00391-8 · 2002 · External reference
Understanding the genetic basis of congenital insensitivity to pain
10.1093/bmb/ldaa003 · 2020 · External reference
Attenuated cold sensitivity in TRPM8 null mice
10.1016/j.neuron.2007.04.017 · 2007 · External reference
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain
10.1056/nejmoa2209870 · 2023 · External reference
Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice
10.1007/s00395-020-0780-8 · 2020 · External reference
Nav-igating through a complex landscape: SCN10A and cardiac conduction
10.1172/jci75240 · 2014 · External reference
Silent cold-sensing neurons contribute to cold allodynia in neuropathic pain
10.1093/brain/awab086 · 2021 · External reference
The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain
10.1371/journal.pone.0007383 · 2009 · External reference
Multiple modes of calcium-induced calcium release in sympathetic neurons II: a [Ca2+](i)- and location-dependent transition from endoplasmic reticulum Ca accumulation to net Ca release
10.1085/jgp.118.1.101 · 2001 · External reference
Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons
10.1074/jbc.271.11.5953 · 1996 · External reference
Na(v) 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity
10.1186/1744-8069-2-5 · 2006 · External reference
Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice
10.1007/s00395-020-0780-8 · ExternalCitation · doi-reference
Expression and role of voltage-gated sodium channels in human dorsal root ganglion neurons with special focus on Nav1.7, species differences, and regulation by paclitaxel
10.1007/s12264-017-0132-3 · ExternalCitation · doi-reference
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice
10.1016/0028-3908(90)90145-h · ExternalCitation · doi-reference
Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain
10.1016/0304-3959(94)90023-x · ExternalCitation · doi-reference
Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models
10.1016/j.neulet.2021.135844 · ExternalCitation · doi-reference
Attenuated cold sensitivity in TRPM8 null mice
10.1016/j.neuron.2007.04.017 · ExternalCitation · doi-reference
Neuronal voltage-gated calcium channels: structure, function, and dysfunction
10.1016/j.neuron.2014.03.016 · ExternalCitation · doi-reference
Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain
10.1016/j.neuron.2016.07.044 · ExternalCitation · doi-reference
Molecular mechanisms of cold pain
10.1016/j.ynpai.2020.100044 · ExternalCitation · doi-reference
Long-term enhancement of synaptic transmission induced by veratridine in rat CA3 hippocampal neurons
10.1016/s0168-0102(01)00199-7 · ExternalCitation · doi-reference
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8
10.1016/s0304-3959(01)00391-8 · ExternalCitation · doi-reference
Cold allodynia and hyperalgesia in neuropathic pain: the effect of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine--a double-blind, cross-over comparison with alfentanil and placebo
10.1016/s0304-3959(02)00122-7 · ExternalCitation · doi-reference
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels
10.1016/s0896-6273(00)81133-2 · ExternalCitation · doi-reference
The role of voltage-gated sodium channels in neuropathic pain
10.1016/s0959-4388(03)00074-6 · ExternalCitation · doi-reference
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
10.1038/379257a0 · ExternalCitation · doi-reference
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
10.1038/nature05880 · ExternalCitation · doi-reference
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex
10.1038/nm.2345 · ExternalCitation · doi-reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · ExternalCitation · doi-reference
Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons
10.1038/srep45221 · ExternalCitation · doi-reference
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain
10.1056/nejmoa2209870 · ExternalCitation · doi-reference
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
10.1073/pnas.0611364104 · ExternalCitation · doi-reference
Nifedipine facilitates neurotransmitter release independently of calcium channels
10.1073/pnas.0936131100 · ExternalCitation · doi-reference
Cold sensing by NaV1.8-positive and NaV1.8-negative sensory neurons
10.1073/pnas.1814545116 · ExternalCitation · doi-reference
Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8
10.1073/pnas.2208211119 · ExternalCitation · doi-reference
Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons
10.1074/jbc.271.11.5953 · ExternalCitation · doi-reference
Multiple modes of calcium-induced calcium release in sympathetic neurons II: a [Ca2+](i)- and location-dependent transition from endoplasmic reticulum Ca accumulation to net Ca release
10.1085/jgp.118.1.101 · ExternalCitation · doi-reference
Understanding the genetic basis of congenital insensitivity to pain
10.1093/bmb/ldaa003 · ExternalCitation · doi-reference
Silent cold-sensing neurons contribute to cold allodynia in neuropathic pain
10.1093/brain/awab086 · ExternalCitation · doi-reference
Calcium channel modulation as a target in chronic pain control
10.1111/bph.13789 · ExternalCitation · doi-reference
The effect of calcium channel antagonists on peripheral neurones
10.1111/j.1749-6632.1988.tb33364.x · ExternalCitation · doi-reference
A quantitative description of membrane current and its application to conduction and excitation in nerve
10.1113/jphysiol.1952.sp004764 · ExternalCitation · doi-reference
Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro
10.1113/jphysiol.1990.sp018094 · ExternalCitation · doi-reference
A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats
10.1124/jpet.107.134148 · ExternalCitation · doi-reference
Nav-igating through a complex landscape: SCN10A and cardiac conduction
10.1172/jci75240 · ExternalCitation · doi-reference
Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay
10.1177/1744806917745179 · ExternalCitation · doi-reference
Nav1.7 and Nav1.8: Role in the pathophysiology of pain
10.1177/1744806919858801 · ExternalCitation · doi-reference
Na(v) 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity
10.1186/1744-8069-2-5 · ExternalCitation · doi-reference
Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice
10.1186/s12974-024-03018-6 · ExternalCitation · doi-reference
The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain
10.1371/journal.pone.0007383 · ExternalCitation · doi-reference
Thy1-GCaMP6 transgenic mice for neuronal population imaging in vivo
10.1371/journal.pone.0108697 · ExternalCitation · doi-reference
Chemogenetic silencing of Na(V)1.8-positive sensory neurons reverses chronic neuropathic and bone cancer pain in FLEx PSAM(4)-GlyR mice
10.1523/eneuro.0151-23.2023 · ExternalCitation · doi-reference
Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons
10.1523/jneurosci.22-23-10277.2002 · ExternalCitation · doi-reference
Targeting chronic and neuropathic pain: the N-type calcium channel comes of age
10.1602/neurorx.2.4.662 · ExternalCitation · doi-reference
Ion Channel Genes in Painful Neuropathies
10.3390/biomedicines11102680 · ExternalCitation · doi-reference
In vivo calcium imaging of neuronal ensembles in networks of primary sensory neurons in intact dorsal root ganglia
10.3791/64826 · ExternalCitation · doi-reference
Dorsal Root Ganglion (DRG) and Chronic Pain
10.5812/aapm.113020 · ExternalCitation · doi-reference
