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References from Multiple simulated spaceflight stressors impact cardiac fibrosis, calcium dynamics, immune function, cytokines and gene variants in rat, Rattus norvegicus. Local targets link to admitted publications; unresolved targets remain external evidence.
Physical basis of radiation protection in space travel
10.1103/revmodphys.83.1245 · 2011 · External reference
Exposure to multiple ion beams, broadly representative of galactic cosmic rays, causes perivascular cardiac fibrosis in mature male rats
10.1371/journal.pone.0283877 · 2023 · External reference
NASA’s first ground-based Galactic Cosmic Ray Simulator: Enabling a new era in space radiobiology research
10.1371/journal.pbio.3000669 · 2020 · External reference
Resistive exercise in astronauts on prolonged spaceflights provides partial protection against spaceflight-induced bone loss
10.1016/j.bone.2019.07.013 · 2019 · External reference
Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells
2023 · External reference
Alterations in adaptive immunity persist during long-duration spaceflight
10.1038/npjmgrav.2015.13 · 2015 · External reference
Plasma cytokine concentrations indicate that in vivo hormonal regulation of immunity is altered during long-duration spaceflight
10.1089/jir.2013.0129 · 2014 · External reference
Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight
10.3389/fphys.2019.00085 · 2019 · External reference
Alterations in Saliva and Plasma Cytokine Concentrations During Long-Duration Spaceflight
10.3389/fimmu.2021.725748 · 2021 · External reference
Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents
10.1038/s41598-021-90010-2 · 2021 · External reference
Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
2025 · External reference
Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming
10.1007/s00411-025-01108-4 · 2025 · External reference
Initial events in the cellular effects of ionizing radiations: clustered damage in DNA
10.1080/09553009414550021 · 1994 · External reference
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
10.1056/nejmoa1701719 · 2017 · External reference
Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma and Brain of Behaviorally Tested WAG/Rij Rats
10.3389/fphys.2021.746509 · 2021 · External reference
Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats
10.3389/fphys.2024.1486767 · 2024 · External reference
10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model
10.3109/09553000903264473 · 2009 · External reference
Breaking free of sample size dogma to perform innovative translational research
10.1126/scitranslmed.3001628 · 2011 · External reference
Justifying small-n research in scientifically amazing settings: challenging the notion that only “big-n” studies are worthwhile
10.1152/japplphysiol.01335.2013 · 2014 · External reference
Unresolved reference
External reference
Overview of the NASA space radiation laboratory
2016 · External reference
Spaceflight-Relevant Challenges of Radiation and/or Reduced Weight Bearing Cause Arthritic Responses in Knee Articular Cartilage
10.1667/rr14400.1 · 2016 · External reference
Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats
10.1667/rr15043.1 · 2019 · External reference
Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system
10.1096/fba.2020-00071 · 2020 · External reference
Cardiac injury after 10 gy total body irradiation: indirect role of effects on abdominal organs
10.1667/rr3292.1 · 2013 · External reference
Dietary Effects on Dahl Salt-Sensitive Hypertension, Renal Damage, and the T Lymphocyte Transcriptome
10.1161/hypertensionaha.119.12927 · 2019 · External reference
Rodent immunohistochemistry: pitfalls and troubleshooting
10.1177/0300985813503571 · 2014 · External reference
Inverse co-expression of EZH2 and acetylated H3K27 in prostatic tissue
10.1016/j.anndiagpath.2022.151956 · 2022 · External reference
Age-related clonal hematopoiesis associated with adverse outcomes
10.1056/nejmoa1408617 · 2014 · External reference
Gene ontology: tool for the unification of biology
10.1038/75556 · 2000 · External reference
The Gene Ontology knowledgebase in 2023
2023 · External reference
KEGG: kyoto encyclopedia of genes and genomes
10.1093/nar/28.1.27 · 2000 · External reference
ShinyGO: a graphical gene-set enrichment tool for animals and plants
10.1093/bioinformatics/btz931 · 2020 · External reference
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
10.1111/j.2517-6161.1995.tb02031.x · 1995 · External reference
An analysis of variance test for normality (complete samples)
10.1093/biomet/52.3-4.591 · 1965 · External reference
2022 updates to the Rat Genome Database: a Findable, Accessible, Interoperable, and Reusable (FAIR) resource
10.1093/genetics/iyad042 · 2023 · External reference
Ataxia-telangiectasia-like disorder (ATLD)—its clinical presentation and molecular basis
10.1016/j.dnarep.2004.04.009 · 2004 · External reference
Ataxia telangiectasia: a review
10.1186/s13023-016-0543-7 · 2016 · External reference
Decreased non-MHC-restricted (CD56+) killer cell cytotoxicity after spaceflight
10.1152/jappl.2001.91.4.1814 · 2001 · External reference
Late Effects of Heavy-Ion Space Radiation on Splenocyte Subpopulations and NK Cytotoxic Function
10.3389/fspas.2022.949432 · 2022 · External reference
Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen
2021 · External reference
Immune resistance of man in space flights
10.1016/0094-5765(91)90108-h · 1991 · External reference
Immunosuppression during spaceflight deconditioning
1998 · External reference
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
10.1126/science.aau8650 · 2019 · External reference
The Laboratory Rat: Relating Its Age With Human’s
2013 · External reference
IDH2 Mutations from Clonal Hematopoiesis and Acquired IKZF1 Deletions Define a Novel B-ALL Subtype after Lenalidomide Therapy for Multiple Myeloma
10.1182/blood-2024-199601 · 2024 · External reference
Clonal hematopoiesis and bone marrow failure syndromes
10.1016/j.beha.2021.101273 · 2021 · External reference
BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis
10.1161/circulationaha.123.065344 · 2023 · External reference
Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens
10.1182/blood-2018-03-840629 · 2018 · External reference
Clonal Hematopoiesis Before, During, and After Human Spaceflight
10.1016/j.celrep.2020.108458 · 2020 · External reference
Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts
10.1038/s42003-022-03777-z · 2022 · External reference
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
10.1056/nejmoa1409405 · 2014 · External reference
Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight
10.1359/jbmr.040307 · 2004 · External reference
Unresolved reference
2011 · External reference
The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station
10.1093/jn/135.3.437 · 2005 · External reference
25-hydroxyvitamin D levels and the risk of mortality in the general population
10.1001/archinte.168.15.1629 · 2008 · External reference
25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies
10.1161/atvbaha.112.248039 · 2012 · External reference
Changes in serum concentrations of calcium and its regulating hormones during tail suspension in rats
1996 · External reference
Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells
10.3390/ijms221910507 · 2021 · External reference
Interplay of space radiation and microgravity in DNA damage and DNA damage response
10.1038/s41526-017-0019-7 · 2017 · External reference
Lifetime Evaluation of Left Ventricular Structure and Function in Male C57BL/6J Mice after Gamma and Space-Type Radiation Exposure
10.3390/ijms24065451 · 2023 · External reference
Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats
2020 · External reference
Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
2023 · External reference
Unresolved reference
External reference
Unresolved reference
2021 · External reference
Unresolved reference
2022 · External reference
Induction of sister chromatid exchanges by extremely low doses of alpha-particles
1992 · External reference
The radiation-induced bystander effect: evidence and significance
10.1191/0960327104ht418oa · 2004 · External reference
The potential impact of bystander effects on radiation risks in a Mars mission
10.1667/0033-7587(2001)156[0612:tpiobe]2.0.co;2 · 2001 · External reference
Understanding cancer development processes after HZE-particle exposure: roles of ROS, DNA damage repair and inflammation
10.1667/rr13804.1 · 2015 · External reference