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References from Protective effects of Crocin on hepatic steatosis, oxidative stress, and lipid profile in an animal model of non-alcoholic fatty liver disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
10.1007/s00018-018-2860-6 · 2018 · External reference
Non-alcoholic fatty liver disease
10.1016/s0140-6736(20)32511-3 · 2021 · External reference
Unresolved reference
External reference
The prevalence and incidence of NAFLD worldwide: A systematic review and meta-analysis
10.1016/s2468-1253(22)00165-0 · 2022 · External reference
Non-alcoholic fatty liver disease
10.3109/10408363.2011.596521 · 2011 · External reference
Nonalcoholic fatty liver disease
10.1038/nrdp.2015.80 · 2015 · External reference
Nonalcoholic fatty liver disease: A global perspective
10.1016/j.clinthera.2021.01.007 · 2021 · External reference
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): A systematic review
10.1097/hep.0000000000000004 · 2023 · External reference
Past, present and future perspectives in nonalcoholic fatty liver disease
10.1038/s41575-019-0144-8 · 2019 · External reference
The role of metformin in the management of NAFLD
10.1155/2012/716404 · 2012 · External reference
Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease
10.3748/wjg.v13.i26.3540 · 2007 · External reference
Nonalcoholic fatty liver disease 2020: The state of the disease
10.1053/j.gastro.2020.01.052 · 2020 · External reference
AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease
10.1097/hep.0000000000000323 · 2023 · External reference
The effect of saffron supplementation on some inflammatory and oxidative markers, leptin, adiponectin, and body composition in patients with nonalcoholic fatty liver disease: A double-blind randomized clinical trial
10.1002/ptr.6791 · 2020 · External reference
Insulin resistance and NAFLD: A Dangerous Liaison beyond the Genetics
2017 · External reference
The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
10.1002/hep.25762 · 2012 · External reference
The role of the lipogenic pathway in the development of hepatic steatosis
10.1016/s1262-3636(08)74599-3 · 2008 · External reference
What medical oncologist residents think about the Italian speciality schools: A survey of the Italian Association of Medical Oncology (AIOM) on Educational, Clinical and Research Activities
10.1371/journal.pone.0159146 · 2016 · External reference
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease
10.1053/j.gastro.2010.07.057 · 2010 · External reference
Effect of saffron extract and crocin in serum metabolites of induced obesity rats
2020 · External reference
Possible anti-obesity therapeutics from nature--A review
10.1016/j.phytochem.2010.07.011 · 2010 · External reference
Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: A clinical review
10.1016/j.phrs.2017.12.020 · 2018 · External reference
Clinical applications of Saffron (Crocus sativus) and its constituents: A review
2015 · External reference
Cultivation, distribution, taxonomy, chemical composition and medical importance of Crocus sativus
10.31254/phyto.2017.6610 · 2017 · External reference
Phytochemical analysis and antioxidant activity of different tissue types of Crocus sativus and oxidative stress alleviating potential of saffron extract in plants, bacteria, and yeast
10.1016/j.sajb.2015.03.194 · 2015 · External reference
Saffron extract and crocin reduced biomarkers associated with obesity in rats fed a high-fat diet
2017 · External reference
Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet
10.1016/j.jff.2014.03.017 · 2014 · External reference
Crocin modulates IL-4/IL-13 signaling and ameliorates experimentally induced allergic airway asthma in a murine model
10.1016/j.intimp.2017.07.012 · 2017 · External reference
Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice
10.1186/s12944-018-0955-6 · 2019 · External reference
Crocin inhibits obesity via AMPK-dependent inhibition of adipocyte differentiation and promotion of lipolysis
10.5582/bst.2018.01240 · 2018 · External reference
Inhibitory effect of crocin on hepatic steatosis in the rats fed with high fat diet
10.3923/javaa.2012.2373.2379 · 2012 · External reference
Metformin improved memory impairment caused by chronic ethanol consumption during adolescent to adult period of rats: Role of oxidative stress and neuroinflammation
10.1016/j.bbr.2021.113399 · 2021 · External reference
Design and statistical methods in studies using animal models of development
10.1093/ilar.47.1.5 · 2006 · External reference
Feeding crocin ameliorate cognitive dysfunction, oxidative stress and neuroinflammation induced by unpredictable chronic mild stress in rats
10.1007/s10787-023-01250-9 · 2023 · External reference
Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats
2005 · External reference
Association of serum 25-hydroxy vitamin D status with cardiometabolic risk factors and total and regional obesity in southern Iran: evidence from the PoCOsteo study
10.1038/s41598-024-68773-1 · 2024 · External reference
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
10.1093/ajcp/28.1.56 · 1957 · External reference
10.1016/s0021-9258(18)43072-4
10.1016/s0021-9258(18)43072-4 · External reference
Dietary antioxidants and liver enzymes in Rafsanjan, a Region in Southeast Iran
10.1038/s41598-023-35385-0 · 2023 · External reference
Vitamin B12 administration prevents ethanol-induced learning and memory impairment through re-establishment of the brain oxidant/antioxidant balance, enhancement of BDNF and suppression of GFAP
10.1016/j.bbr.2022.114156 · 2023 · External reference
Anti-rheumatic activity of topical nanoemulsion containing bee venom in rats
10.1016/j.ejpb.2022.02.005 · 2022 · External reference
Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology
10.1371/journal.pone.0115922 · 2014 · External reference
Ethnicity and nonalcoholic fatty liver disease
10.1002/hep.24726 · 2012 · External reference
High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms
10.1016/j.cbi.2020.109199 · 2020 · External reference
Nonalcoholic fatty liver disease induced by high-fat diet in C57bl/6 models
10.3390/nu11123067 · 2019 · External reference
Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats
10.1186/s12906-016-1381-9 · 2016 · External reference
Attenuation of high-fat diet-induced rat liver oxidative stress and steatosis by combined hydroxytyrosol- (HT-) eicosapentaenoic acid supplementation mainly relies on HT
10.1155/2018/5109503 · 2018 · External reference
Free radicals, antioxidants and functional foods: Impact on human health
10.4103/0973-7847.70902 · 2010 · External reference
MicroRNA regulation of AMPK in nonalcoholic fatty liver disease
10.1038/s12276-023-01072-3 · 2023 · External reference
Crocin improves insulin sensitivity and ameliorates adiposity by regulating AMPK-CDK5-PPARgamma signaling
10.1155/2020/9136282 · 2020 · External reference
Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway
10.1186/s12967-024-05592-y · 2024 · External reference
Therapeutic Effect of Crocin on the NASH model by targeting the fas receptor signaling pathway
10.5152/tjg.2022.21088 · 2022 · External reference
Effect of crocin on the insulin resistance and lipid profile of streptozotocin-induced diabetic rats
10.1002/ptr.4836 · 2013 · External reference
Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats
2019 · External reference
Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase
10.1016/j.ejphar.2006.05.038 · 2006 · External reference
Crocin (active constituent of saffron) improves CCl 4 -induced liver damage by modulating oxidative stress in rats
10.1515/tjb-2017-0173 · 2019 · External reference
Crocin attenuates CCl4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats
10.1177/0960327120937048 · 2020 · External reference
Crocin possesses excellent hepatoprotective effects against acetaminophen-induced hepatotoxicity in mice
10.5812/jjnpp.115165 · 2022 · External reference
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
10.1016/j.metabol.2015.12.012 · 2016 · External reference
Efficacy of orlistat in obese patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials
2024 · External reference
AMPK: Mechanisms of cellular energy sensing and restoration of metabolic balance
10.1016/j.molcel.2017.05.032 · 2017 · External reference
Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats
10.1016/j.biopha.2017.12.077 · 2018 · External reference
Polydatin: A critical promising natural agent for liver protection via antioxidative stress
10.1155/2022/9218738 · 2022 · External reference
Therapeutic effects of Crocin in autoimmune diseases: A review
10.1002/biof.1557 · 2019 · External reference
Activation of apoptosis signalling pathways by reactive oxygen species
10.1016/j.bbamcr.2016.09.012 · 2016 · External reference
Crocin prevents sub-cellular organelle damage, proteolysis and apoptosis in rat hepatocytes: A justification for its hepatoprotection
2018 · External reference
Crocin attenuates cisplatin-induced liver injury in the mice
10.1177/0960327113511475 · 2014 · External reference
Moderating effects of crocin on some stress oxidative markers in rat brain following demyelination with ethidium bromide
10.1016/j.heliyon.2019.e01213 · 2019 · External reference
Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats
10.1016/j.pharep.2019.04.004 · 2019 · External reference
Animal models of steatosis
10.1055/s-2001-12932 · 2001 · External reference
Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet
10.1016/j.fct.2010.04.044 · 2010 · External reference
Targeting NF-kappa B/proinflammatory cytokines/ TGF-β/ TIMP-1 pathway by crocin enhances recovery from hepatic fibrosis in rats
10.1038/s41598-025-32672-w · 2026 · External reference
The hepatoprotective and MicroRNAs downregulatory effects of Crocin following hepatic ischemia-reperfusion injury in rats
10.1155/2017/1702967 · 2017 · External reference
Crocin and nano-Crocin mitigate paraquat hepatotoxicity by modulating expression of genes involved in oxidative stress and inflammation
2025 · External reference
Inflammatory markers response to crocin supplementation in patients with type 2 diabetes mellitus: A randomized controlled trial
10.1002/ptr.7124 · 2021 · External reference
Effects of crocin on inflammatory biomarkers and mental health status in patients with multiple sclerosis: A randomized, double-blinded clinical trial
10.1016/j.msard.2024.105454 · 2024 · External reference
