Research graph
References from Endosome restricted human TLR1 polymorphism highlights a role for MyD88 in Pam3CSK4 detection. Local targets link to admitted publications; unresolved targets remain external evidence.
Phagosomal TLR signaling upon Borrelia burgdorferi infection
2014 · External reference
TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi
10.1128/iai.00890-12 · 2013 · External reference
Toll-like receptor signaling in teleosts
10.1007/s11427-024-2822-5 · 2025 · External reference
TLR-dependent human mucosal epithelial cell responses to microbial pathogens
10.3389/fimmu.2014.00386 · 2014 · External reference
Regulation of immune responses by nonhematopoietic cells in Asthma
10.4049/jimmunol.2000885 · 2021 · External reference
How location governs toll-like receptor signaling
10.1111/j.1600-0854.2009.00899.x · 2009 · External reference
Human integrin α(3)β(1) regulates TLR2 recognition of lipopeptides from endosomal compartments
10.1371/journal.pone.0012871 · 2010 · External reference
TRAM is required for TLR2 endosomal signaling to type I IFN induction
10.4049/jimmunol.1401605 · 2014 · External reference
An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling
10.1111/tra.12870 · 2022 · External reference
Adaptor protein-3-mediated trafficking of TLR2 ligands controls specificity of inflammatory responses but not adaptor complex assembly
10.4049/jimmunol.1501268 · 2015 · External reference
TRAM is required for TLR2 endosomal signaling to type I IFN induction
10.4049/jimmunol.1401605 · 2014 · External reference
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling
10.1074/jbc.m114.593426 · 2015 · External reference
Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells
10.1016/j.immuni.2012.02.018 · 2012 · External reference
New findings of Toll-like receptors involved in Mycobacterium tuberculosis infection
10.1080/20477724.2017.1351080 · 2017 · External reference
Leprosy and the adaptation of human toll-like receptor 1
2010 · External reference
Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction
10.1371/journal.pntd.0000231 · 2008 · External reference
Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria
10.4049/jimmunol.1201545 · 2012 · External reference
Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection
2012 · External reference
Hitchhiker’s Guide to Borrelia burgdorferi
10.1128/jb.00116-24 · 2024 · External reference
Diagnosis and treatment of Lyme arthritis
10.1016/j.idc.2015.02.004 · 2015 · External reference
A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice
10.4049/jimmunol.181.12.8492 · 2008 · External reference
Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K
10.4049/jimmunol.0900724 · 2009 · External reference
Mechanisms of Borrelia burgdorferi internalization and intracellular innate immune signaling
10.3389/fcimb.2014.00175 · 2014 · External reference
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy
10.4049/jimmunol.178.12.7520 · 2007 · External reference
Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B
10.1074/jbc.m112.342717 · 2012 · External reference
Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis
10.1002/art.34383 · 2012 · External reference
A comprehensive genetic map of cytokine responses in Lyme borreliosis
10.1038/s41467-024-47505-z · 2024 · External reference
TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes
10.1371/journal.pone.0025998 · 2011 · External reference
Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis
10.3389/fimmu.2025.1711765 · 2025 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
10.1038/ni1569 · 2008 · External reference
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
10.1016/j.cell.2011.09.051 · 2011 · External reference
Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha
10.1021/bi901948j · 2010 · External reference
Inhibitory feedback control of NF-κB signalling in health and disease
10.1042/bcj20210139 · 2021 · External reference
Toll-like receptor signaling in primary immune deficiencies
10.1111/nyas.12763 · 2015 · External reference
TLRs and chronic inflammation
10.1016/j.biocel.2009.10.010 · 2010 · External reference
Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands
10.4049/jimmunol.172.2.1256 · 2004 · External reference
Toll-like receptor 1 polymorphisms increased the risk of pulmonary tuberculosis in an iranian population sample
2016 · External reference
Phosphoinositide transport and metabolism at membrane contact sites
10.1016/j.bbalip.2021.159107 · 2022 · External reference
Toll-like receptors and innate immunity
10.1038/35100529 · 2001 · External reference
Toll-like receptor signaling and its role in cell-mediated immunity
10.3389/fimmu.2022.812774 · 2022 · External reference
IRAP, TRAM, and Toll-Like Receptors: The Untold Story.
2023 · External reference
Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus
10.4049/jimmunol.1000110 · 2010 · External reference
TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88
10.1371/journal.pone.0038423 · 2012 · External reference
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction
10.1016/j.cell.2014.01.019 · 2014 · External reference
Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation
10.1371/journal.ppat.1011886 · 2023 · External reference
The aconitate decarboxylase 1/itaconate pathway modulates immune dysregulation and associates with cardiovascular disease markers and disease activity in systemic lupus erythematosus
10.4049/jimmunol.2400241 · 2024 · External reference
Site-specific methylation of a TLR1 promoter SNP impedes CREB binding to impair antibacterial immunity in grass carp
2026 · External reference
Highly pathogenic avian influenza H5N1 viruses elicit an attenuated type i interferon response in polarized human bronchial epithelial cells
10.1128/jvi.01134-07 · 2007 · External reference
An alternative model for type I interferon induction downstream of human TLR2
10.1074/jbc.ra120.015283 · 2020 · External reference
Borrelia burgdorferi-induced expression of matrix metalloproteinases from human chondrocytes requires mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription signaling pathways
10.1128/iai.72.5.2864-2871.2004 · 2004 · External reference
