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References from Insulin enhances RAGE ectodomain shedding by inducing Rab14-dependent ADAM10 cell surface trafficking in human aortic endothelial cells. Local targets link to admitted publications; unresolved targets remain external evidence.
The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation
10.3390/ijms21051835 · 2020 · External reference
Advanced Glycation End Products: key player of the pathogenesis of atherosclerosis
10.1007/s10719-022-10063-x · 2022 · External reference
Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications
10.1016/j.atherosclerosis.2007.07.025 · 2008 · External reference
Insulin’s actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes
10.1016/j.molmet.2021.101236 · 2021 · External reference
Oral insulin supplementation attenuates atherosclerosis progression in apolipoprotein E-deficient mice
10.1161/01.atv.0000042232.42883.56 · 2003 · External reference
Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus
10.1056/nejmoa022314 · 2003 · External reference
Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes
2015 · External reference
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
10.1073/pnas.0709805104 · 2007 · External reference
Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence
10.1186/s12964-023-01072-w · 2023 · External reference
Localization of ADAM10 and Notch receptors in bone
10.1016/s8756-3282(99)00099-x · 1999 · External reference
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles
10.1096/fj.02-0430fje · 2003 · External reference
Epigallocatechin-3-gallate downregulates lipopolysaccharide signaling in human aortic endothelial cells by inducing ectodomain shedding of TLR4
10.1016/j.ejphar.2019.172692 · 2019 · External reference
Liraglutide, a glucagon-like peptide-1 receptor agonist, induces ADAM10-dependent ectodomain shedding of RAGE via AMPK activation in human aortic endothelial cells
10.1016/j.lfs.2022.120331 · 2022 · External reference
AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation
10.1016/j.bbrc.2023.07.010 · 2023 · External reference
AKT activation triggers Rab14-mediated ADAM10 translocation to the cell surface in human aortic endothelial cells
10.1038/s41598-025-90624-w · 2025 · External reference
Regulation of RabGAPs involved in insulin action
10.1042/bst20170479 · 2018 · External reference
AKT/PKB Signaling: Navigating the Network
10.1016/j.cell.2017.04.001 · 2017 · External reference
Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis
10.1074/jbc.m211136200 · 2003 · External reference
AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor
10.1080/15384101.2018.1515550 · 2018 · External reference
The metalloproteinase ADAM10 requires its activity to sustain surface expression
10.1007/s00018-020-03507-w · 2021 · External reference
Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14
2018 · External reference
Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells
10.1016/j.devcel.2012.04.010 · 2012 · External reference
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential
10.3390/ijms22136707 · 2021 · External reference
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
10.1083/jcb.201201133 · 2012 · External reference
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression
10.1074/jbc.m112.416503 · 2012 · External reference
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins
10.1042/bst20160290 · 2017 · External reference
Rab14 is involved in membrane trafficking between the Golgi complex and endosomes
10.1091/mbc.e03-10-0777 · 2004 · External reference
Rab14 regulates apical targeting in polarized epithelial cells
10.1111/j.1600-0854.2008.00752.x · 2008 · External reference
AKT ISOFORMS-AS160-GLUT4: The defining axis of insulin resistance
10.1007/s11154-021-09652-2 · 2021 · External reference
Role of Akt isoforms in neuronal insulin signaling and resistance
10.1007/s00018-021-03993-6 · 2021 · External reference
Knowledge based identification of essential signaling from genome-scale siRNA experiments
10.1186/1752-0509-3-80 · 2009 · External reference
Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice
10.3389/fcvm.2023.974918 · 2023 · External reference
Insulin: too much of a good thing is bad
10.1186/s12916-020-01688-6 · 2020 · External reference
Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses
10.1016/j.metabol.2009.07.039 · 2010 · External reference
Insulin structure and stability
10.1007/978-1-4899-1236-7_11 · 1993 · External reference
The “specific” binding of insulin to polythene and other materials
10.1016/0304-4165(75)90158-0 · 1975 · External reference
Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes
10.1016/j.mam.2015.01.003 · 2015 · External reference
Insulin structure and stability
10.1007/978-1-4899-1236-7_11 · ExternalCitation · doi-reference
The metalloproteinase ADAM10 requires its activity to sustain surface expression
10.1007/s00018-020-03507-w · ExternalCitation · doi-reference
Role of Akt isoforms in neuronal insulin signaling and resistance
10.1007/s00018-021-03993-6 · ExternalCitation · doi-reference
Advanced Glycation End Products: key player of the pathogenesis of atherosclerosis
10.1007/s10719-022-10063-x · ExternalCitation · doi-reference
AKT ISOFORMS-AS160-GLUT4: The defining axis of insulin resistance
10.1007/s11154-021-09652-2 · ExternalCitation · doi-reference
The “specific” binding of insulin to polythene and other materials
10.1016/0304-4165(75)90158-0 · ExternalCitation · doi-reference
Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications
10.1016/j.atherosclerosis.2007.07.025 · ExternalCitation · doi-reference
AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation
10.1016/j.bbrc.2023.07.010 · ExternalCitation · doi-reference
AKT/PKB Signaling: Navigating the Network
10.1016/j.cell.2017.04.001 · ExternalCitation · doi-reference
Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells
10.1016/j.devcel.2012.04.010 · ExternalCitation · doi-reference
Epigallocatechin-3-gallate downregulates lipopolysaccharide signaling in human aortic endothelial cells by inducing ectodomain shedding of TLR4
10.1016/j.ejphar.2019.172692 · ExternalCitation · doi-reference
Liraglutide, a glucagon-like peptide-1 receptor agonist, induces ADAM10-dependent ectodomain shedding of RAGE via AMPK activation in human aortic endothelial cells
10.1016/j.lfs.2022.120331 · ExternalCitation · doi-reference
Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes
10.1016/j.mam.2015.01.003 · ExternalCitation · doi-reference
Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses
10.1016/j.metabol.2009.07.039 · ExternalCitation · doi-reference
Insulin’s actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes
10.1016/j.molmet.2021.101236 · ExternalCitation · doi-reference
Localization of ADAM10 and Notch receptors in bone
10.1016/s8756-3282(99)00099-x · ExternalCitation · doi-reference
AKT activation triggers Rab14-mediated ADAM10 translocation to the cell surface in human aortic endothelial cells
10.1038/s41598-025-90624-w · ExternalCitation · doi-reference
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins
10.1042/bst20160290 · ExternalCitation · doi-reference
Regulation of RabGAPs involved in insulin action
10.1042/bst20170479 · ExternalCitation · doi-reference
Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus
10.1056/nejmoa022314 · ExternalCitation · doi-reference
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
10.1073/pnas.0709805104 · ExternalCitation · doi-reference
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression
10.1074/jbc.m112.416503 · ExternalCitation · doi-reference
Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis
10.1074/jbc.m211136200 · ExternalCitation · doi-reference
AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor
10.1080/15384101.2018.1515550 · ExternalCitation · doi-reference
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
10.1083/jcb.201201133 · ExternalCitation · doi-reference
Rab14 is involved in membrane trafficking between the Golgi complex and endosomes
10.1091/mbc.e03-10-0777 · ExternalCitation · doi-reference
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles
10.1096/fj.02-0430fje · ExternalCitation · doi-reference
Rab14 regulates apical targeting in polarized epithelial cells
10.1111/j.1600-0854.2008.00752.x · ExternalCitation · doi-reference
Oral insulin supplementation attenuates atherosclerosis progression in apolipoprotein E-deficient mice
10.1161/01.atv.0000042232.42883.56 · ExternalCitation · doi-reference
Knowledge based identification of essential signaling from genome-scale siRNA experiments
10.1186/1752-0509-3-80 · ExternalCitation · doi-reference
Insulin: too much of a good thing is bad
10.1186/s12916-020-01688-6 · ExternalCitation · doi-reference
Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence
10.1186/s12964-023-01072-w · ExternalCitation · doi-reference
Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice
10.3389/fcvm.2023.974918 · ExternalCitation · doi-reference
The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation
10.3390/ijms21051835 · ExternalCitation · doi-reference
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential
10.3390/ijms22136707 · ExternalCitation · doi-reference
