Research graph
References from A microbiome–metabolome signature associated with pediatric severe asthma. Local targets link to admitted publications; unresolved targets remain external evidence.
Understanding asthma phenotypes, endotypes, and mechanisms of disease
10.1007/s12016-018-8712-1 · 2019 · External reference
Severe asthma in children: Evaluation and management
10.1016/j.alit.2018.11.007 · 2019 · External reference
A Comprehensive Analysis of Immune Constituents in Blood and Bronchoalveolar Lavage Allows Identification of an Immune Signature of Severe Asthma in Children
10.3389/fimmu.2021.700521 · 2021 · External reference
Evaluation of the association of mucosa-associated invariant T (MAIT) cells with childhood asthma
10.55730/1300-0144.5908 · 2024 · External reference
TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status
10.1016/j.jaci.2017.08.020 · 2018 · External reference
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
10.1183/09031936.00202013 · 2014 · External reference
Epidemiology of severe asthma in children: a systematic review and meta-analysis
10.1183/16000617.0095-2024 · 2024 · External reference
Prevalence of severe childhood asthma according to the WHO
10.1016/j.rmed.2014.05.015 · 2014 · External reference
Worldwide trends in the burden of asthma symptoms in school-aged children: Global Asthma Network Phase I cross-sectional study
10.1016/s0140-6736(21)01450-1 · 2021 · External reference
Severe childhood asthma in low and middle-income countries
2026 · External reference
Assessment of airway inflammation and remodeling in children with severe asthma: The next challenge
10.1002/ppul.24051 · 2018 · External reference
Respiratory microbiome and epithelial interactions shape immunity in the lungs
10.1111/imm.13195 · 2020 · External reference
Upper and lower airway microbiota across infancy and childhood
10.1038/s41390-025-03942-0 · 2025 · External reference
The role of lung and gut microbiota in the pathology of asthma
10.1016/j.immuni.2020.01.007 · 2020 · External reference
Le poumon est sensible aux effets locaux et à distance des microbiotes
10.1016/j.nupar.2021.04.002 · 2021 · External reference
Paradigms of lung microbiota functions in health and disease, particularly, in asthma
10.3389/fphys.2018.01168 · 2018 · External reference
The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development
10.1016/j.chom.2015.03.008 · 2015 · External reference
Airway microbiota dynamics uncover a critical window for interplay of pathogenic bacteria and allergy in childhood respiratory disease
2018 · External reference
Maturation of the Infant Respiratory Microbiota, Environmental Drivers, and Health Consequences. A Prospective Cohort Study
10.1164/rccm.201703-0554oc · 2017 · External reference
The role of the local microbial ecosystem in respiratory health and disease
10.1098/rstb.2014.0294 · 2015 · External reference
The airway microbiome in patients with severe asthma: Associations with disease features and severity
10.1016/j.jaci.2015.05.044 · 2015 · External reference
Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma
10.1183/13993003.00405-2015 · 2016 · External reference
Disordered microbial communities in asthmatic airways
10.1371/journal.pone.0008578 · 2010 · External reference
Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma
10.1371/journal.pone.0100645 · 2014 · External reference
Integrative study of the upper and lower airway microbiome and transcriptome in asthma
10.1172/jci.insight.133707 · 2020 · External reference
A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma
10.1016/j.jaci.2017.04.021 · 2018 · External reference
Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment
10.3390/metabo11040251 · 2021 · External reference
Metabolomics of bronchoalveolar lavage in children with persistent wheezing
10.1186/s12931-022-02087-6 · 2022 · External reference
Metabolomics in Childhood Asthma - a Promising Tool to Meet Various Clinical Needs
10.1007/s11882-025-01198-6 · 2025 · External reference
Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma
10.1016/j.jaci.2024.08.017 · 2025 · External reference
Immune signatures distinguish frequent from non-frequent exacerbators among children with severe asthma
10.1111/all.14759 · 2021 · External reference
DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays
10.1093/bioinformatics/bty1054 · 2019 · External reference
Evidence for a MAIT-17-high phenotype in children with severe asthma
10.1016/j.jaci.2019.08.003 · 2019 · External reference
Datasets of 16S rRNA gene amplicon sequences, metabolites, and soluble immune components in bronchoalveolar lavage samples from severe asthmatic and age-matched control children
10.1016/j.dib.2025.112359 · 2025 · External reference
Unresolved reference
2025 · External reference
Unresolved reference
2025 · External reference
Quantitative analysis of small-subunit rRNA genes in mixed microbial populations via 5’-nuclease assays
10.1128/aem.66.11.4605-4614.2000 · 2000 · External reference
Faecal D/L lactate ratio is a metabolic signature of microbiota imbalance in patients with short bowel syndrome
10.1371/journal.pone.0054335 · 2013 · External reference
Nasopharyngeal microbiota in children is associated with severe asthma exacerbations
10.1016/j.jaci.2024.02.020 · 2024 · External reference
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation
10.1093/nar/gkae253 · 2024 · External reference
Childhood respiratory viral infections and the microbiome
10.1016/j.jaci.2023.08.008 · 2023 · External reference
Comprehensive investigation of pathway enrichment methods for functional interpretation of LC-MS global metabolomics data
2023 · External reference
An integrated metabo-lipidomics profile of induced sputum for the identification of novel biomarkers in the differential diagnosis of asthma and COPD
10.1186/s12967-024-05100-2 · 2024 · External reference
Partial Least Squares Discriminant Analysis and Bayesian Networks for Metabolomic Prediction of Childhood Asthma
10.3390/metabo8040068 · 2018 · External reference
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
10.1016/j.cellimm.2024.104815 · 2024 · External reference
The respiratory microbiota alpha-diversity in chronic lung diseases: first systematic review and meta-analysis
10.1186/s12931-022-02132-4 · 2022 · External reference
The Interactions of Airway Bacterial and Fungal Communities in Clinically Stable Asthma
10.3389/fmicb.2020.01647 · 2020 · External reference
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
10.1016/j.jaci.2010.10.048 · 2011 · External reference
Asthma-associated differences in microbial composition of induced sputum
10.1016/j.jaci.2012.11.013 · 2013 · External reference
Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways
10.1016/j.jaci.2015.10.017 · 2016 · External reference
Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation
10.1111/all.15776 · 2023 · External reference
Altered respiratory microbiota composition and functionality associated with asthma early in life
10.1186/s12879-020-05427-3 · 2020 · External reference
Lower airway microbiome of children with recurrent wheezing: a clinical cohort study
10.21037/tp-22-165 · 2022 · External reference
Elevated levels of peripheral-blood, naturally occurring aliphatic polyamines in bronchial asthmatic patients with active symptoms
10.1111/j.1398-9995.1992.tb02388.x · 1992 · External reference
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma
10.1165/rcmb.2012-0323oc · 2013 · External reference
Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features
10.1111/all.13472 · 2018 · External reference
Spermidine and spermine exert protective effects within the lung
10.1002/prp2.837 · 2021 · External reference
Spermidine Suppresses Inflammatory DC function by activating the FOXO3 pathway and counteracts autoimmunity
10.1016/j.isci.2019.100807 · 2020 · External reference
Regulating T-cell differentiation through the polyamine spermidine
10.1016/j.jaci.2020.04.037 · 2021 · External reference
The polyamine spermine promotes survival and activation of human eosinophils
10.1016/j.jaci.2014.12.1922 · 2015 · External reference
Metabotypes of Pseudomonas aeruginosa Correlate with Antibiotic Resistance, Virulence and Clinical Outcome in Cystic Fibrosis Chronic Infections
10.3390/metabo11020063 · 2021 · External reference
The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae
10.1186/s41479-021-00082-x · 2021 · External reference
Spermidine enhances the survival of Streptococcus pyogenes M3 under oxidative stress
10.1111/omi.12360 · 2022 · External reference
The upper-airway microbiota and loss of asthma control among asthmatic children
10.1038/s41467-019-13698-x · 2019 · External reference
Temporal dynamics of the nasopharyngeal microbiome and its relationship with childhood asthma exacerbation
2022 · External reference
Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma
10.1016/j.jaci.2019.05.035 · 2019 · External reference
Tryptophan metabolism in health and disease- implications for non-communicable diseases
10.1016/j.imlet.2025.107093 · 2026 · External reference
Serum metabolomics study and eicosanoid analysis of childhood atopic dermatitis based on liquid chromatography–mass spectrometry
10.1021/pr5007069 · 2014 · External reference
The IDO–AhR axis controls Th17/Treg Immunity in a Pulmonary Model of Fungal Infection
10.3389/fimmu.2017.00880 · 2017 · External reference
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells
10.1016/j.immuni.2017.01.005 · 2017 · External reference
A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia
10.1002/ctm2.70007 · 2024 · External reference
The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease
10.1016/j.jaci.2020.02.040 · 2021 · External reference
Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease
10.1126/scitranslmed.aav3879 · 2019 · External reference
The effect of different inhaled corticosteroid and long-acting bronchodilator combinations on the airway microbiome in patients with severe COPD: a randomised trial (MUSIC)
10.1183/13993003.00287-2025 · 2025 · External reference
Unresolved reference
2018 · External reference
A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia
10.1002/ctm2.70007 · ExternalCitation · doi-reference
Assessment of airway inflammation and remodeling in children with severe asthma: The next challenge
10.1002/ppul.24051 · ExternalCitation · doi-reference
Spermidine and spermine exert protective effects within the lung
10.1002/prp2.837 · ExternalCitation · doi-reference
Metabolomics in Childhood Asthma - a Promising Tool to Meet Various Clinical Needs
10.1007/s11882-025-01198-6 · ExternalCitation · doi-reference
Understanding asthma phenotypes, endotypes, and mechanisms of disease
10.1007/s12016-018-8712-1 · ExternalCitation · doi-reference
Severe asthma in children: Evaluation and management
10.1016/j.alit.2018.11.007 · ExternalCitation · doi-reference
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
10.1016/j.cellimm.2024.104815 · ExternalCitation · doi-reference
The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development
10.1016/j.chom.2015.03.008 · ExternalCitation · doi-reference
Datasets of 16S rRNA gene amplicon sequences, metabolites, and soluble immune components in bronchoalveolar lavage samples from severe asthmatic and age-matched control children
10.1016/j.dib.2025.112359 · ExternalCitation · doi-reference
Tryptophan metabolism in health and disease- implications for non-communicable diseases
10.1016/j.imlet.2025.107093 · ExternalCitation · doi-reference
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells
10.1016/j.immuni.2017.01.005 · ExternalCitation · doi-reference
The role of lung and gut microbiota in the pathology of asthma
10.1016/j.immuni.2020.01.007 · ExternalCitation · doi-reference
Spermidine Suppresses Inflammatory DC function by activating the FOXO3 pathway and counteracts autoimmunity
10.1016/j.isci.2019.100807 · ExternalCitation · doi-reference
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
10.1016/j.jaci.2010.10.048 · ExternalCitation · doi-reference
Asthma-associated differences in microbial composition of induced sputum
10.1016/j.jaci.2012.11.013 · ExternalCitation · doi-reference
The polyamine spermine promotes survival and activation of human eosinophils
10.1016/j.jaci.2014.12.1922 · ExternalCitation · doi-reference
The airway microbiome in patients with severe asthma: Associations with disease features and severity
10.1016/j.jaci.2015.05.044 · ExternalCitation · doi-reference
Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways
10.1016/j.jaci.2015.10.017 · ExternalCitation · doi-reference
A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma
10.1016/j.jaci.2017.04.021 · ExternalCitation · doi-reference
TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status
10.1016/j.jaci.2017.08.020 · ExternalCitation · doi-reference
Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma
10.1016/j.jaci.2019.05.035 · ExternalCitation · doi-reference
Evidence for a MAIT-17-high phenotype in children with severe asthma
10.1016/j.jaci.2019.08.003 · ExternalCitation · doi-reference
The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease
10.1016/j.jaci.2020.02.040 · ExternalCitation · doi-reference
Regulating T-cell differentiation through the polyamine spermidine
10.1016/j.jaci.2020.04.037 · ExternalCitation · doi-reference
Childhood respiratory viral infections and the microbiome
10.1016/j.jaci.2023.08.008 · ExternalCitation · doi-reference
Nasopharyngeal microbiota in children is associated with severe asthma exacerbations
10.1016/j.jaci.2024.02.020 · ExternalCitation · doi-reference
Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma
10.1016/j.jaci.2024.08.017 · ExternalCitation · doi-reference
Le poumon est sensible aux effets locaux et à distance des microbiotes
10.1016/j.nupar.2021.04.002 · ExternalCitation · doi-reference
Prevalence of severe childhood asthma according to the WHO
10.1016/j.rmed.2014.05.015 · ExternalCitation · doi-reference
Worldwide trends in the burden of asthma symptoms in school-aged children: Global Asthma Network Phase I cross-sectional study
10.1016/s0140-6736(21)01450-1 · ExternalCitation · doi-reference
Serum metabolomics study and eicosanoid analysis of childhood atopic dermatitis based on liquid chromatography–mass spectrometry
10.1021/pr5007069 · ExternalCitation · doi-reference
Upper and lower airway microbiota across infancy and childhood
10.1038/s41390-025-03942-0 · ExternalCitation · doi-reference
The upper-airway microbiota and loss of asthma control among asthmatic children
10.1038/s41467-019-13698-x · ExternalCitation · doi-reference
DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays
10.1093/bioinformatics/bty1054 · ExternalCitation · doi-reference
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation
10.1093/nar/gkae253 · ExternalCitation · doi-reference
The role of the local microbial ecosystem in respiratory health and disease
10.1098/rstb.2014.0294 · ExternalCitation · doi-reference
Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features
10.1111/all.13472 · ExternalCitation · doi-reference
Immune signatures distinguish frequent from non-frequent exacerbators among children with severe asthma
10.1111/all.14759 · ExternalCitation · doi-reference
Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation
10.1111/all.15776 · ExternalCitation · doi-reference
Respiratory microbiome and epithelial interactions shape immunity in the lungs
10.1111/imm.13195 · ExternalCitation · doi-reference
Elevated levels of peripheral-blood, naturally occurring aliphatic polyamines in bronchial asthmatic patients with active symptoms
10.1111/j.1398-9995.1992.tb02388.x · ExternalCitation · doi-reference
Spermidine enhances the survival of Streptococcus pyogenes M3 under oxidative stress
10.1111/omi.12360 · ExternalCitation · doi-reference
Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease
10.1126/scitranslmed.aav3879 · ExternalCitation · doi-reference
Quantitative analysis of small-subunit rRNA genes in mixed microbial populations via 5’-nuclease assays
10.1128/aem.66.11.4605-4614.2000 · ExternalCitation · doi-reference
Maturation of the Infant Respiratory Microbiota, Environmental Drivers, and Health Consequences. A Prospective Cohort Study
10.1164/rccm.201703-0554oc · ExternalCitation · doi-reference
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma
10.1165/rcmb.2012-0323oc · ExternalCitation · doi-reference
Integrative study of the upper and lower airway microbiome and transcriptome in asthma
10.1172/jci.insight.133707 · ExternalCitation · doi-reference
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
10.1183/09031936.00202013 · ExternalCitation · doi-reference
The effect of different inhaled corticosteroid and long-acting bronchodilator combinations on the airway microbiome in patients with severe COPD: a randomised trial (MUSIC)
10.1183/13993003.00287-2025 · ExternalCitation · doi-reference
Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma
10.1183/13993003.00405-2015 · ExternalCitation · doi-reference
Epidemiology of severe asthma in children: a systematic review and meta-analysis
10.1183/16000617.0095-2024 · ExternalCitation · doi-reference
Altered respiratory microbiota composition and functionality associated with asthma early in life
10.1186/s12879-020-05427-3 · ExternalCitation · doi-reference
Metabolomics of bronchoalveolar lavage in children with persistent wheezing
10.1186/s12931-022-02087-6 · ExternalCitation · doi-reference
The respiratory microbiota alpha-diversity in chronic lung diseases: first systematic review and meta-analysis
10.1186/s12931-022-02132-4 · ExternalCitation · doi-reference
An integrated metabo-lipidomics profile of induced sputum for the identification of novel biomarkers in the differential diagnosis of asthma and COPD
10.1186/s12967-024-05100-2 · ExternalCitation · doi-reference
The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae
10.1186/s41479-021-00082-x · ExternalCitation · doi-reference
Disordered microbial communities in asthmatic airways
10.1371/journal.pone.0008578 · ExternalCitation · doi-reference
Faecal D/L lactate ratio is a metabolic signature of microbiota imbalance in patients with short bowel syndrome
10.1371/journal.pone.0054335 · ExternalCitation · doi-reference
Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma
10.1371/journal.pone.0100645 · ExternalCitation · doi-reference
Lower airway microbiome of children with recurrent wheezing: a clinical cohort study
10.21037/tp-22-165 · ExternalCitation · doi-reference
The IDO–AhR axis controls Th17/Treg Immunity in a Pulmonary Model of Fungal Infection
10.3389/fimmu.2017.00880 · ExternalCitation · doi-reference
A Comprehensive Analysis of Immune Constituents in Blood and Bronchoalveolar Lavage Allows Identification of an Immune Signature of Severe Asthma in Children
10.3389/fimmu.2021.700521 · ExternalCitation · doi-reference
The Interactions of Airway Bacterial and Fungal Communities in Clinically Stable Asthma
10.3389/fmicb.2020.01647 · ExternalCitation · doi-reference
Paradigms of lung microbiota functions in health and disease, particularly, in asthma
10.3389/fphys.2018.01168 · ExternalCitation · doi-reference
Metabotypes of Pseudomonas aeruginosa Correlate with Antibiotic Resistance, Virulence and Clinical Outcome in Cystic Fibrosis Chronic Infections
10.3390/metabo11020063 · ExternalCitation · doi-reference
Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment
10.3390/metabo11040251 · ExternalCitation · doi-reference
Partial Least Squares Discriminant Analysis and Bayesian Networks for Metabolomic Prediction of Childhood Asthma
10.3390/metabo8040068 · ExternalCitation · doi-reference
Evaluation of the association of mucosa-associated invariant T (MAIT) cells with childhood asthma
10.55730/1300-0144.5908 · ExternalCitation · doi-reference
